HUMAN:HMOX1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HMOX1 (synonyms: HO, HO1)
Protein Name(s)	Heme oxygenase 1 HO-1
External Links
UniProt	P09601
EMBL	X06985 CR456505 AY460337 Z82244 M23041 X14782
CCDS	CCDS13914.1
PIR	S00325
RefSeq	NP_002124.1
UniGene	Hs.517581
PDB	1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM
PDBsum	1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM
ProteinModelPortal	P09601
SMR	P09601
BioGrid	109405
IntAct	P09601
STRING	9606.ENSP00000216117
BindingDB	P09601
ChEMBL	CHEMBL2823
DrugBank	DB00163
PhosphoSite	P09601
DMDM	123446
MaxQB	P09601
PaxDb	P09601
PRIDE	P09601
DNASU	3162
Ensembl	ENST00000216117
GeneID	3162
KEGG	hsa:3162
UCSC	uc003ant.2
CTD	3162
GeneCards	GC22P035776
HGNC	HGNC:5013
HPA	CAB017444 HPA000635
MIM	141250 614034
neXtProt	NX_P09601
PharmGKB	PA29341
eggNOG	COG5398
HOGENOM	HOG000233221
HOVERGEN	HBG005982
InParanoid	P09601
KO	K00510
OMA	YAPLYFP
PhylomeDB	P09601
TreeFam	TF314786
BioCyc	MetaCyc:HS02027-MONOMER
Reactome	REACT_22297 REACT_25060
EvolutionaryTrace	P09601
GeneWiki	HMOX1
GenomeRNAi	3162
NextBio	12538
PRO	PR:P09601
Proteomes	UP000005640
Bgee	P09601
CleanEx	HS_HMOX1
ExpressionAtlas	P09601
Genevestigator	P09601
GO	GO:0005901 GO:0005829 GO:0005783 GO:0005789 GO:0005615 GO:0016020 GO:0005730 GO:0005634 GO:0048471 GO:0019899 GO:0020037 GO:0004392 GO:0046872 GO:0004630 GO:0042803 GO:0004871 GO:0001525 GO:0008219 GO:0006879 GO:0071243 GO:0071276 GO:0071456 GO:0031670 GO:0001935 GO:0034101 GO:0007588 GO:0042167 GO:0006788 GO:0035556 GO:0008630 GO:0055072 GO:0034383 GO:0043392 GO:1902042 GO:0002686 GO:0032764 GO:0043305 GO:0010656 GO:0043524 GO:0043433 GO:0048662 GO:0006778 GO:0045766 GO:0045080 GO:0043123 GO:0048661 GO:0045909 GO:0051260 GO:0045765 GO:0008217 GO:0051090 GO:0034395 GO:0043619 GO:0043627 GO:0042542 GO:0035094 GO:0006979 GO:0007264 GO:0044281 GO:0014806 GO:0055085 GO:0002246
Gene3D	1.20.910.10
InterPro	IPR002051 IPR016053 IPR016084 IPR018207
PANTHER	PTHR10720
Pfam	PF01126
PIRSF	PIRSF000343
PRINTS	PR00088
SUPFAM	SSF48613
PROSITE	PS00593

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0042542	response to hydrogen peroxide	PMID:22989377^[1]	ECO:0000315			P		Figure 1 shows overexpression of HO1 leads to less loss of viability due to H2O2 treatment.	complete CACAO 5572
	GO:0006879	cellular iron ion homeostasis	PMID:22989377^[1]	ECO:0000315			P		Figure 2B shows overexpression of HO1 leads to increased bound intracellular iron.	complete CACAO 5573
	GO:0004392	heme oxygenase (decyclizing) activity	PMID:27058954^[2]	ECO:0000316		PMID:27058954^[2] InterPro:IPR016084 UniProtKB:P09601 (HMOX1_HUMAN)	F		A group of experimental scientists analyzed the global mRNa expression and the methylation profiles in APP to identify the genes involved to be able to treat Alzheimer's. They particularly focused on the functions of protein heme oxygenase 1 found in gene HMOX1. The group of researchers basically evaluated the how important the protein HMOX1 is in Alzheimer's. For this experiment, the scientists used human blood and lab mice. This was an extremely extensive project as plenty of processes were involved. The processes were: - RNA extraction (qRT), quantitative reverse-transcription polymerase chain reaction (PCR), Transcriptome sequential analysis, Western blot analysis, genomic DNA extraction, genomic DNA modification, Methylation microarray, Quantitative methylation-specific PCR (qMSP), bisulfite sequential analysis, deoxycytidine treatment, amyloid preparation and treatment and in the end Statistical Analysis. Figure 1 shows the HMOX1 expression up-regulated in an APP-mutant cell line and transgenic mice.The effect of the protein is heavily evaluated by the virtue of its effects on the minds of mice. Alzheimer's is a disease that is becoming increasingly common in humans and therefore, this experiment is significant in understanding the pros and cons of this enzyme so that we can come up with better treatments for this amnesic disease. The results of this experiment showed that heme oxygenase 1 is in fact directly correlated with Alzheimer's as shown from the results in Figures 1,2,3,4,5 and 6. The statistical analysis also convinced the researchers that HMOX1 is a key factor in cognitive impairment of Alzheimer's.	complete CACAO 11564
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:24844779^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00001230A0_9606	P	results_in_movement_of:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	PMID:24844779^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00001230A0_9606	P	results_in_division_of:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:21788589^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	PMID:22989377^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:21597468^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:22503972^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:22503972^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:18202225^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	PMID:9884342^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	PMID:17915953^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06762	P		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	PMID:17915953^[9]	ECO:0000305	curator inference used in manual assertion	GO:0004392	P		Seeded From UniProt	complete
involved_in	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06762	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06762	P		Seeded From UniProt	complete
involved_in	GO:0042167	heme catabolic process	PMID:17915953^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:18205746^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034101	erythrocyte homeostasis	PMID:9884342^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:17915953^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:15516695^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06762	F		Seeded From UniProt	complete
involved_in	GO:0008219	cell death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06762	P		Seeded From UniProt	complete
involved_in	GO:0007588	excretion	PMID:17915953^[9]	ECO:0000305	curator inference used in manual assertion	GO:0004392	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:9884342^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006788	heme oxidation	PMID:17915953^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06762	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06762	C		Seeded From UniProt	complete
enables	GO:0004392	heme oxygenase (decyclizing) activity	PMID:17915953^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002246	wound healing involved in inflammatory response	PMID:9884342^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:12511571^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:19556236^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	PMID:17600318^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:17600318^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12761501^[15]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:19556236^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:19556236^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004392	heme oxygenase (decyclizing) activity	PMID:19556236^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076411 UniProtKB:P09601	P		Seeded From UniProt	complete
involved_in	GO:0042167	heme catabolic process	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076411 RGD:2806 SGD:S000004195 UniProtKB:P09601	P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076411 RGD:2806 UniProtKB:P09601	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076411 SGD:S000004195	C		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076411 RGD:2806 RGD:67402 SGD:S000004195 UniProtKB:P09601	P		Seeded From UniProt	complete
involved_in	GO:0006788	heme oxidation	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076411 UniProtKB:P09601	P		Seeded From UniProt	complete
enables	GO:0004392	heme oxygenase (decyclizing) activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037933 PANTHER:PTN000076411 RGD:2806 RGD:67402 SGD:S000004195 UniProtKB:P09601 UniProtKB:P30519 ZFIN:ZDB-GENE-030131-3102	F		Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:1904036	negative regulation of epithelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0043305	negative regulation of mast cell degranulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0042167	heme catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0032764	negative regulation of mast cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0031670	cellular response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	F		Seeded From UniProt	complete
involved_in	GO:0010656	negative regulation of muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0008219	cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0007264	small GTPase mediated signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	C		Seeded From UniProt	complete
enables	GO:0004630	phospholipase D activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	F		Seeded From UniProt	complete
enables	GO:0004392	heme oxygenase (decyclizing) activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06762 ensembl:ENSRNOP00000019192	P		Seeded From UniProt	complete
involved_in	GO:0072719	cellular response to cisplatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P		Seeded From UniProt	complete
involved_in	GO:0071276	cellular response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P		Seeded From UniProt	complete
involved_in	GO:0071243	cellular response to arsenic-containing substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P		Seeded From UniProt	complete
involved_in	GO:0042168	heme metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P		Seeded From UniProt	complete
involved_in	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P		Seeded From UniProt	complete
involved_in	GO:0016242	negative regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	C		Seeded From UniProt	complete
enables	GO:0004392	heme oxygenase (decyclizing) activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002051 InterPro:IPR016053 InterPro:IPR018207	F		Seeded From UniProt	complete
involved_in	GO:0006788	heme oxidation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002051 InterPro:IPR016053	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002051 InterPro:IPR016053 InterPro:IPR018207	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:3345742^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:3345742^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004392	heme oxygenase (decyclizing) activity	PMID:9884342^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045765	regulation of angiogenesis	PMID:17652371^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045080	positive regulation of chemokine biosynthetic process	PMID:17652371^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:17652371^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034383	low-density lipoprotein particle clearance	PMID:9884342^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014806	smooth muscle hyperplasia	PMID:18289072^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18307065^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002686	negative regulation of leukocyte migration	PMID:14525760^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001935	endothelial cell proliferation	PMID:12239590^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:12239590^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042167	heme catabolic process	Reactome:R-HSA-189483	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	Reactome:R-HSA-917937	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-6797268 Reactome:R-HSA-189398	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492 UniProtKB-SubCell:SL-0166	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
edit table

Notes====References

↑ ^1.0 ^1.1 ^1.2 Lanceta, L et al. (2013) Haem oxygenase-1 overexpression alters intracellular iron distribution. Biochem. J. 449 189-94 PubMed GONUTS page
↑ ^2.0 ^2.1 Sung, HY et al. () Amyloid Beta-Mediated Hypomethylation of Heme Oxygenase 1 Correlates with Cognitive Impairment in Alzheimer's Disease. PLoS ONE 11 e0153156 PubMed GONUTS page
↑ ^3.0 ^3.1 Kim, JH et al. (2014) Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3. Antioxid. Redox Signal. 21 2469-82 PubMed GONUTS page
↑ Fiedler, J et al. (2011) MicroRNA-24 regulates vascularity after myocardial infarction. Circulation 124 720-30 PubMed GONUTS page
↑ Kaitsuka, T et al. (2011) Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing. EMBO Rep. 12 673-81 PubMed GONUTS page
↑ ^6.0 ^6.1 Jiang, J et al. (2012) Stanniocalcin 2, forms a complex with heme oxygenase 1, binds hemin and is a heat shock protein. Biochem. Biophys. Res. Commun. 421 274-9 PubMed GONUTS page
↑ Rushworth, SA & MacEwan, DJ (2008) HO-1 underlies resistance of AML cells to TNF-induced apoptosis. Blood 111 3793-801 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Yachie, A et al. (1999) Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J. Clin. Invest. 103 129-35 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Huber, WJ 3rd & Backes, WL (2007) Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase. Biochemistry 46 12212-9 PubMed GONUTS page
↑ Lee, HJ et al. (2008) Differential induction of heme oxygenase-1 against nicotine-induced cytotoxicity via the PI3K, MAPK, and NF-kappa B pathways in immortalized and malignant human oral keratinocytes. J. Oral Pathol. Med. 37 278-86 PubMed GONUTS page
↑ Higashimoto, Y et al. (2005) Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase. J. Biol. Chem. 280 729-37 PubMed GONUTS page
↑ Kitamuro, T et al. (2003) Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells. J. Biol. Chem. 278 9125-33 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Hwang, HW et al. (2009) Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum. J. Biol. Chem. 284 22672-9 PubMed GONUTS page
↑ ^14.0 ^14.1 Yang, X et al. (2007) BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes. Am. J. Respir. Cell Mol. Biol. 37 598-605 PubMed GONUTS page
↑ Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^17.0 ^17.1 Yoshida, T et al. (1988) Human heme oxygenase cDNA and induction of its mRNA by hemin. Eur. J. Biochem. 171 457-61 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Datta, D et al. (2007) Heme oxygenase-1 modulates the expression of the anti-angiogenic chemokine CXCL-10 in renal tubular epithelial cells. Am. J. Physiol. Renal Physiol. 293 F1222-30 PubMed GONUTS page
↑ Xia, ZW et al. (2008) The role of heme oxygenase-1 in T cell-mediated immunity: the all encompassing enzyme. Curr. Pharm. Des. 14 454-64 PubMed GONUTS page
↑ Eide, IP et al. (2008) Decidual expression and maternal serum levels of heme oxygenase 1 are increased in pre-eclampsia. Acta Obstet Gynecol Scand 87 272-9 PubMed GONUTS page
↑ Bussolati, B et al. (2004) Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration. Blood 103 761-6 PubMed GONUTS page
↑ ^22.0 ^22.1 Malaguarnera, L et al. (2002) Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells. Int. J. Mol. Med. 10 433-40 PubMed GONUTS page

[PMID:22989377-1] 1.0 ^1.1 ^1.2 Lanceta, L et al. (2013) Haem oxygenase-1 overexpression alters intracellular iron distribution. Biochem. J. 449 189-94 PubMed GONUTS page

[PMID:27058954-2] 2.0 ^2.1 Sung, HY et al. () Amyloid Beta-Mediated Hypomethylation of Heme Oxygenase 1 Correlates with Cognitive Impairment in Alzheimer's Disease. PLoS ONE 11 e0153156 PubMed GONUTS page

[PMID:24844779-3] 3.0 ^3.1 Kim, JH et al. (2014) Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3. Antioxid. Redox Signal. 21 2469-82 PubMed GONUTS page

[PMID:21788589-4] Fiedler, J et al. (2011) MicroRNA-24 regulates vascularity after myocardial infarction. Circulation 124 720-30 PubMed GONUTS page

[PMID:21597468-5] Kaitsuka, T et al. (2011) Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing. EMBO Rep. 12 673-81 PubMed GONUTS page

[PMID:22503972-6] 6.0 ^6.1 Jiang, J et al. (2012) Stanniocalcin 2, forms a complex with heme oxygenase 1, binds hemin and is a heat shock protein. Biochem. Biophys. Res. Commun. 421 274-9 PubMed GONUTS page

[PMID:18202225-7] Rushworth, SA & MacEwan, DJ (2008) HO-1 underlies resistance of AML cells to TNF-induced apoptosis. Blood 111 3793-801 PubMed GONUTS page

[PMID:9884342-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Yachie, A et al. (1999) Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J. Clin. Invest. 103 129-35 PubMed GONUTS page

[PMID:17915953-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Huber, WJ 3rd & Backes, WL (2007) Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase. Biochemistry 46 12212-9 PubMed GONUTS page

[PMID:18205746-10] Lee, HJ et al. (2008) Differential induction of heme oxygenase-1 against nicotine-induced cytotoxicity via the PI3K, MAPK, and NF-kappa B pathways in immortalized and malignant human oral keratinocytes. J. Oral Pathol. Med. 37 278-86 PubMed GONUTS page

[PMID:15516695-11] Higashimoto, Y et al. (2005) Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase. J. Biol. Chem. 280 729-37 PubMed GONUTS page

[PMID:12511571-12] Kitamuro, T et al. (2003) Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells. J. Biol. Chem. 278 9125-33 PubMed GONUTS page

[PMID:19556236-13] 13.0 ^13.1 ^13.2 ^13.3 Hwang, HW et al. (2009) Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum. J. Biol. Chem. 284 22672-9 PubMed GONUTS page

[PMID:17600318-14] 14.0 ^14.1 Yang, X et al. (2007) BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes. Am. J. Respir. Cell Mol. Biol. 37 598-605 PubMed GONUTS page

[PMID:12761501-15] Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:3345742-17] 17.0 ^17.1 Yoshida, T et al. (1988) Human heme oxygenase cDNA and induction of its mRNA by hemin. Eur. J. Biochem. 171 457-61 PubMed GONUTS page

[PMID:17652371-18] 18.0 ^18.1 ^18.2 Datta, D et al. (2007) Heme oxygenase-1 modulates the expression of the anti-angiogenic chemokine CXCL-10 in renal tubular epithelial cells. Am. J. Physiol. Renal Physiol. 293 F1222-30 PubMed GONUTS page

[PMID:18289072-19] Xia, ZW et al. (2008) The role of heme oxygenase-1 in T cell-mediated immunity: the all encompassing enzyme. Curr. Pharm. Des. 14 454-64 PubMed GONUTS page

[PMID:18307065-20] Eide, IP et al. (2008) Decidual expression and maternal serum levels of heme oxygenase 1 are increased in pre-eclampsia. Acta Obstet Gynecol Scand 87 272-9 PubMed GONUTS page

[PMID:14525760-21] Bussolati, B et al. (2004) Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration. Blood 103 761-6 PubMed GONUTS page

[PMID:12239590-22] 22.0 ^22.1 Malaguarnera, L et al. (2002) Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells. Int. J. Mol. Med. 10 433-40 PubMed GONUTS page

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HUMAN:HMOX1

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