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HUMAN:HGFL
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MST1 (synonyms: D3F15S2, DNF15S2, HGFL) | |
| Protein Name(s) | Hepatocyte growth factor-like protein
Macrophage stimulatory protein Macrophage-stimulating protein MSP Hepatocyte growth factor-like protein alpha chain Hepatocyte growth factor-like protein beta chain | |
| External Links | ||
| UniProt | P26927 | |
| EMBL | M74178 U37055 L11924 AC099668 BC048330 | |
| PIR | A40331 | |
| RefSeq | NP_066278.3 | |
| UniGene | Hs.349110 Hs.512587 | |
| PDB | 2ASU 4QT8 | |
| PDBsum | 2ASU 4QT8 | |
| ProteinModelPortal | P26927 | |
| SMR | P26927 | |
| BioGrid | 110591 | |
| DIP | DIP-6028N | |
| IntAct | P26927 | |
| MINT | MINT-4787531 | |
| STRING | 9606.ENSP00000414287 | |
| ChEMBL | CHEMBL6042 | |
| MEROPS | S01.975 | |
| iPTMnet | P26927 | |
| PhosphoSite | P26927 | |
| BioMuta | MST1 | |
| DMDM | 147744563 | |
| MaxQB | P26927 | |
| PaxDb | P26927 | |
| PRIDE | P26927 | |
| Ensembl | ENST00000383728 | |
| GeneID | 4485 | |
| KEGG | hsa:4485 | |
| CTD | 4485 | |
| GeneCards | MST1 | |
| H-InvDB | HIX0024339 | |
| HGNC | HGNC:7380 | |
| HPA | HPA024036 | |
| MalaCards | MST1 | |
| MIM | 142408 | |
| neXtProt | NX_P26927 | |
| Orphanet | 171 | |
| PharmGKB | PA31185 | |
| eggNOG | ENOG410IDXR COG5640 | |
| HOGENOM | HOG000112892 | |
| HOVERGEN | HBG004381 | |
| InParanoid | P26927 | |
| PhylomeDB | P26927 | |
| Reactome | [www.reactome.org/content/detail/R-HSA-8852405 R-HSA-8852405] | |
| SignaLink | P26927 | |
| SIGNOR | P26927 | |
| EvolutionaryTrace | P26927 | |
| GeneWiki | MST1 | |
| GenomeRNAi | 4485 | |
| PMAP-CutDB | P26927 | |
| PRO | PR:P26927 | |
| Proteomes | UP000005640 | |
| Bgee | P26927 | |
| CleanEx | HS_MST1 | |
| GO | GO:0070062 GO:0005576 GO:0005615 GO:0030971 GO:0004252 GO:0048012 GO:0045721 GO:2000479 | |
| InterPro | IPR024174 IPR000001 IPR013806 IPR018056 IPR003609 IPR009003 IPR001314 IPR001254 | |
| Pfam | PF00051 PF00024 PF00089 | |
| PIRSF | PIRSF001152 | |
| PRINTS | PR00722 | |
| SMART | SM00130 SM00473 SM00020 | |
| SUPFAM | SSF50494 SSF57440 | |
| PROSITE | PS00021 PS50070 PS50948 PS50240 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0002107) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045721 |
negative regulation of gluconeogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000479 |
regulation of cAMP-dependent protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0035978 |
histone H2A-S139 phosphorylation |
ECO:0000314 |
P |
A kinase assay showed that MST1 strongly phosphorylated H2AX and western blot analysis showed that MST1 phosphorylated H2AX at ser-139 (Figure 2A and 2B). |
complete | |||||
|
enables |
GO:0030971 |
receptor tyrosine kinase binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0035978 |
histone H2A-S139 phosphorylation |
ECO:0000315 |
P |
Comparing wild type H2AX and mutant H2AX-S139A, the author found that phosphorylation of the mutant H2AX-S139A by MST1 was dramatically decreased confirming that MST1 phosphorylates at S139 (Figure 2C and 2D). |
complete | |||||
|
involved_in |
GO:0033601 |
positive regulation of mammary gland epithelial cell proliferation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96080 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010758 |
regulation of macrophage chemotaxis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96080 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001207579 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048012 |
hepatocyte growth factor receptor signaling pathway |
Reactome:R-HSA-8852405 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-8852552 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
- ↑ Wang, MH et al. (1994) Proteolytic conversion of single chain precursor macrophage-stimulating protein to a biologically active heterodimer by contact enzymes of the coagulation cascade. J. Biol. Chem. 269 3436-40 PubMed GONUTS page
- ↑ 3.0 3.1 Chanda, D et al. (2009) Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. J. Biol. Chem. 284 28510-21 PubMed GONUTS page
- ↑ 4.0 4.1 Wen, W et al. (2010) MST1 promotes apoptosis through phosphorylation of histone H2AX. J. Biol. Chem. 285 39108-16 PubMed GONUTS page
- ↑ Gorlatova, N et al. (2011) Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution. PLoS ONE 6 e27269 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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