HUMAN:GPSM2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GPSM2 (synonyms: LGN)
Protein Name(s)	G-protein-signaling modulator 2 Mosaic protein LGN
External Links
UniProt	P81274
EMBL	U54999 AB445462 AL449266 CH471122 BC027732 AY136740 CR456786
CCDS	CCDS792.2
PIR	JC5334
RefSeq	NP_037428.3 XP_005270844.1 XP_006710651.1
UniGene	Hs.584901 Hs.658489
PDB	3SF4
PDBsum	3SF4
ProteinModelPortal	P81274
SMR	P81274
BioGrid	118949
DIP	DIP-399N
IntAct	P81274
MINT	MINT-3023522
STRING	9606.ENSP00000264126
PhosphoSite	P81274
DMDM	294862507
MaxQB	P81274
PaxDb	P81274
PRIDE	P81274
DNASU	29899
Ensembl	ENST00000264126 ENST00000406462
GeneID	29899
KEGG	hsa:29899
UCSC	uc010ovc.2
CTD	29899
GeneCards	GC01P109417
HGNC	HGNC:29501
HPA	CAB018962 HPA007327 HPA008408
MIM	604213 609245
neXtProt	NX_P81274
Orphanet	90636 314597
PharmGKB	PA134993615
eggNOG	COG0457
GeneTree	ENSGT00530000063126
HOGENOM	HOG000231543
HOVERGEN	HBG051823
InParanoid	P81274
KO	K15837
OMA	IMRSQAK
OrthoDB	EOG7WHH8W
PhylomeDB	P81274
TreeFam	TF328344
GeneWiki	GPSM2
GenomeRNAi	29899
NextBio	52462
PRO	PR:P81274
Proteomes	UP000005640
Bgee	P81274
CleanEx	HS_GPSM2
ExpressionAtlas	P81274
Genevestigator	P81274
GO	GO:0045177 GO:0005938 GO:0005737 GO:0005634 GO:0030695 GO:0042802 GO:0000132 GO:0007186 GO:0060487
Gene3D	1.25.40.10
InterPro	IPR003109 IPR013026 IPR011990 IPR001440 IPR019734
Pfam	PF02188 PF00515 PF13176
SMART	SM00390 SM00028
PROSITE	PS50877 PS50005 PS50293

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0099738	cell cortex region	PMID:23870127^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904778	positive regulation of protein localization to cell cortex	PMID:23870127^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	PMID:23870127^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	PMID:22327364^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	PMID:22327364^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904778	positive regulation of protein localization to cell cortex	PMID:22327364^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0099738	cell cortex region	PMID:22327364^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031291	Ran protein signal transduction	PMID:22327364^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:16458856^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097575	lateral cell cortex	PMID:26766442^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:23027904^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904778	positive regulation of protein localization to cell cortex	PMID:23027904^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060236	regulation of mitotic spindle organization	PMID:23027904^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005938	cell cortex	PMID:22074847^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:22074847^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:22074847^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14980	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:22074847^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:22074847^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q1MX18	F		Seeded From UniProt	complete
involved_in	GO:1905832	positive regulation of spindle assembly	PMID:11781568^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11781568^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	PMID:11781568^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007052	mitotic spindle organization	PMID:21816348^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051661	maintenance of centrosome location	PMID:21816348^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:21816348^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0097431	mitotic spindle pole	PMID:21816348^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:23783028^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0051323)	Seeded From UniProt	complete
enables	GO:0005092	GDP-dissociation inhibitor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8VDU0	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:15537540^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P81274	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005092	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0030695	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005092	P		Seeded From UniProt	complete
part_of	GO:0097575	lateral cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8VDU0 ensembl:ENSMUSP00000029482	C		Seeded From UniProt	complete
enables	GO:0005092	GDP-dissociation inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8VDU0 ensembl:ENSMUSP00000029482	F		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8VDU0 ensembl:ENSMUSP00000029482	F		Seeded From UniProt	complete
enables	GO:0030695	GTPase regulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003109	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:8973305^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0153	C		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0448	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Kiyomitsu, T & Cheeseman, IM (2013) Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase. Cell 154 391-402 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kiyomitsu, T & Cheeseman, IM (2012) Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation. Nat. Cell Biol. 14 311-7 PubMed GONUTS page
↑ Izaki, T et al. (2006) Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. Biochem. Biophys. Res. Commun. 341 1001-6 PubMed GONUTS page
↑ Chiu, CWN et al. (2016) SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex. Dev. Cell 36 50-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Kotak, S et al. (2012) Cortical dynein is critical for proper spindle positioning in human cells. J. Cell Biol. 199 97-110 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Yuzawa, S et al. (2011) Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN). Proc. Natl. Acad. Sci. U.S.A. 108 19210-5 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Du, Q et al. (2001) A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization. Nat. Cell Biol. 3 1069-75 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Zhu, J et al. (2011) LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways. Mol. Cell 43 418-31 PubMed GONUTS page
↑ Bird, SL et al. (2013) RanGTP and CLASP1 cooperate to position the mitotic spindle. Mol. Biol. Cell 24 2506-14 PubMed GONUTS page
↑ Du, Q & Macara, IG (2004) Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins. Cell 119 503-16 PubMed GONUTS page
↑ Mochizuki, N et al. (1996) Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2. Gene 181 39-43 PubMed GONUTS page

[PMID:23870127-1] 1.0 ^1.1 ^1.2 Kiyomitsu, T & Cheeseman, IM (2013) Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase. Cell 154 391-402 PubMed GONUTS page

[PMID:22327364-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kiyomitsu, T & Cheeseman, IM (2012) Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation. Nat. Cell Biol. 14 311-7 PubMed GONUTS page

[PMID:16458856-3] Izaki, T et al. (2006) Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. Biochem. Biophys. Res. Commun. 341 1001-6 PubMed GONUTS page

[PMID:26766442-4] Chiu, CWN et al. (2016) SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex. Dev. Cell 36 50-62 PubMed GONUTS page

[PMID:23027904-5] 5.0 ^5.1 ^5.2 Kotak, S et al. (2012) Cortical dynein is critical for proper spindle positioning in human cells. J. Cell Biol. 199 97-110 PubMed GONUTS page

[PMID:22074847-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Yuzawa, S et al. (2011) Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN). Proc. Natl. Acad. Sci. U.S.A. 108 19210-5 PubMed GONUTS page

[PMID:11781568-7] 7.0 ^7.1 ^7.2 Du, Q et al. (2001) A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization. Nat. Cell Biol. 3 1069-75 PubMed GONUTS page

[PMID:21816348-8] 8.0 ^8.1 ^8.2 ^8.3 Zhu, J et al. (2011) LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways. Mol. Cell 43 418-31 PubMed GONUTS page

[PMID:23783028-9] Bird, SL et al. (2013) RanGTP and CLASP1 cooperate to position the mitotic spindle. Mol. Biol. Cell 24 2506-14 PubMed GONUTS page

[PMID:15537540-10] Du, Q & Macara, IG (2004) Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins. Cell 119 503-16 PubMed GONUTS page

[PMID:8973305-11] Mochizuki, N et al. (1996) Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2. Gene 181 39-43 PubMed GONUTS page

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HUMAN:GPSM2

Contents

Annotations

Notes

References

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