HUMAN:GP183

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GPR183 (synonyms: EBI2)
Protein Name(s)	G-protein coupled receptor 183 Epstein-Barr virus-induced G-protein coupled receptor 2 EBI2 EBV-induced G-protein coupled receptor 2
External Links
UniProt	P32249
EMBL	L08177 AK292091 AK313443 AK223390 AL160155 CH471085 BC020752
CCDS	CCDS9492.1
PIR	B45680
RefSeq	NP_004942.1
UniGene	Hs.784
ProteinModelPortal	P32249
SMR	P32249
BioGrid	108212
IntAct	P32249
MINT	MINT-1427405
STRING	9606.ENSP00000365596
GuidetoPHARMACOLOGY	81
PhosphoSite	P32249
DMDM	205371788
MaxQB	P32249
PaxDb	P32249
PeptideAtlas	P32249
PRIDE	P32249
DNASU	1880
Ensembl	ENST00000376414
GeneID	1880
KEGG	hsa:1880
UCSC	uc001vog.3
CTD	1880
GeneCards	GC13M099946
HGNC	HGNC:3128
HPA	CAB033690 HPA028847
MIM	605741
neXtProt	NX_P32249
PharmGKB	PA162390174
eggNOG	NOG145860
GeneTree	ENSGT00760000118784
HOGENOM	HOG000043070
HOVERGEN	HBG101355
InParanoid	P32249
KO	K04305
OMA	LVFYINT
OrthoDB	EOG7VDXPF
PhylomeDB	P32249
TreeFam	TF350009
GeneWiki	GPR183
GenomeRNAi	1880
NextBio	7689
PRO	PR:P32249
Proteomes	UP000005640
Bgee	P32249
CleanEx	HS_GPR183
ExpressionAtlas	P32249
Genevestigator	P32249
GO	GO:0005887 GO:0005886 GO:0004930 GO:0008142 GO:0007186 GO:0006959 GO:0006955 GO:0002313 GO:0030890 GO:0070374
InterPro	IPR000276 IPR017452
Pfam	PF00001
PRINTS	PR00237
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0061470	T follicular helper cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6B2	P	Seeded From UniProt	complete
involved_in	GO:0036145	dendritic cell homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6B2	P	Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6B2	P	Seeded From UniProt	complete
involved_in	GO:0010818	T cell chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6B2	P	Seeded From UniProt	complete
involved_in	GO:0002407	dendritic cell chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6B2	P	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6B2	P	Seeded From UniProt	complete
enables	GO:0008142	oxysterol binding	PMID:24678947^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0030595	leukocyte chemotaxis	PMID:24678947^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000458	regulation of astrocyte chemotaxis	PMID:25297897^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:25297897^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:22875855^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008142	oxysterol binding	PMID:22875855^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:22875855^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:22930711^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008142	oxysterol binding	PMID:22930711^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:22930711^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:22930711^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18628402^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:18628402^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:18628402^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21673108^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	PMID:21673108^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008142	oxysterol binding	PMID:21796212^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:21673108^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006959	humoral immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6B2	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21673108^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0002313	mature B cell differentiation involved in immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6B2	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001201699 UniProtKB:P32249	F	Seeded From UniProt	complete
involved_in	GO:0061470	T follicular helper cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6B2 ensembl:ENSMUSP00000052404	P	Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6B2 ensembl:ENSMUSP00000052404	P	Seeded From UniProt	complete
involved_in	GO:0036145	dendritic cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6B2 ensembl:ENSMUSP00000052404	P	Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6B2 ensembl:ENSMUSP00000052404	P	Seeded From UniProt	complete
involved_in	GO:0030595	leukocyte chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6B2 ensembl:ENSMUSP00000052404	P	Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6B2 ensembl:ENSMUSP00000052404	P	Seeded From UniProt	complete
involved_in	GO:0010818	T cell chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6B2 ensembl:ENSMUSP00000052404	P	Seeded From UniProt	complete
enables	GO:0008142	oxysterol binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6B2 ensembl:ENSMUSP00000052404	F	Seeded From UniProt	complete
involved_in	GO:0006959	humoral immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6B2 ensembl:ENSMUSP00000052404	P	Seeded From UniProt	complete
involved_in	GO:0002407	dendritic cell chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6B2 ensembl:ENSMUSP00000052404	P	Seeded From UniProt	complete
involved_in	GO:0002313	mature B cell differentiation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6B2 ensembl:ENSMUSP00000052404	P	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6B2 ensembl:ENSMUSP00000052404	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR017452	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:8383238^[9] Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:8383238^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:8383238^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:8383238^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8851679 Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-380073	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Gessier, F et al. (2014) Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J. Med. Chem. 57 3358-68 PubMed GONUTS page
↑ ^2.0 ^2.1 Rutkowska, A et al. (2015) EBI2 regulates intracellular signaling and migration in human astrocyte. Glia 63 341-51 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Benned-Jensen, T et al. (2012) Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183). J. Biol. Chem. 287 35470-83 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Zhang, L et al. (2012) Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site. Mol. Pharmacol. 82 1094-103 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Benned-Jensen, T & Rosenkilde, MM (2008) Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist. Mol. Pharmacol. 74 1008-21 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Benned-Jensen, T et al. (2011) Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J. Biol. Chem. 286 29292-302 PubMed GONUTS page
↑ Hannedouche, S et al. (2011) Oxysterols direct immune cell migration via EBI2. Nature 475 524-7 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Birkenbach, M et al. (1993) Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 67 2209-20 PubMed GONUTS page

[PMID:24678947-1] 1.0 ^1.1 Gessier, F et al. (2014) Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J. Med. Chem. 57 3358-68 PubMed GONUTS page

[PMID:25297897-2] 2.0 ^2.1 Rutkowska, A et al. (2015) EBI2 regulates intracellular signaling and migration in human astrocyte. Glia 63 341-51 PubMed GONUTS page

[PMID:22875855-3] 3.0 ^3.1 ^3.2 Benned-Jensen, T et al. (2012) Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183). J. Biol. Chem. 287 35470-83 PubMed GONUTS page

[PMID:22930711-4] 4.0 ^4.1 ^4.2 ^4.3 Zhang, L et al. (2012) Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site. Mol. Pharmacol. 82 1094-103 PubMed GONUTS page

[PMID:18628402-5] 5.0 ^5.1 ^5.2 Benned-Jensen, T & Rosenkilde, MM (2008) Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist. Mol. Pharmacol. 74 1008-21 PubMed GONUTS page

[PMID:21673108-6] 6.0 ^6.1 ^6.2 ^6.3 Benned-Jensen, T et al. (2011) Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J. Biol. Chem. 286 29292-302 PubMed GONUTS page

[PMID:21796212-7] Hannedouche, S et al. (2011) Oxysterols direct immune cell migration via EBI2. Nature 475 524-7 PubMed GONUTS page

[PMID:21873635-8] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8383238-9] 9.0 ^9.1 ^9.2 ^9.3 Birkenbach, M et al. (1993) Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 67 2209-20 PubMed GONUTS page

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HUMAN:GP183

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