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HUMAN:GP126

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) GPR126 (synonyms: DREG, VIGR)
Protein Name(s) G-protein coupled receptor 126

Developmentally regulated G-protein-coupled receptor Vascular inducible G protein-coupled receptor

External Links
UniProt Q86SQ4
EMBL AF216967
AB183546
AB183547
AB183548
AB183549
BX640971
BX640873
AL033377
AL360007
BC075798
AK027843
AK075087
AY181244
AY426673
CCDS CCDS47489.1
CCDS47490.1
CCDS47491.1
CCDS55064.1
RefSeq NP_001027566.1
NP_001027567.1
NP_065188.4
NP_940971.1
UniGene Hs.743302
ProteinModelPortal Q86SQ4
SMR Q86SQ4
BioGrid 121449
STRING 9606.ENSP00000356581
MEROPS S63.020
PhosphoSite Q86SQ4
DMDM 215274152
MaxQB Q86SQ4
PaxDb Q86SQ4
PRIDE Q86SQ4
Ensembl ENST00000230173
ENST00000296932
ENST00000367608
ENST00000367609
GeneID 57211
KEGG hsa:57211
UCSC uc010khc.3
uc010khd.3
uc010khe.3
uc010khf.3
CTD 57211
GeneCards GC06P142622
HGNC HGNC:13841
HPA HPA017346
MIM 606255
612243
neXtProt NX_Q86SQ4
PharmGKB PA134878328
eggNOG NOG12793
GeneTree ENSGT00760000118787
HOVERGEN HBG051778
InParanoid Q86SQ4
KO K08463
OMA NLSCGSY
OrthoDB EOG7ZGX28
PhylomeDB Q86SQ4
TreeFam TF321769
SignaLink Q86SQ4
ChiTaRS GPR126
GeneWiki GPR126
GenomeRNAi 57211
NextBio 63312
PRO PR:Q86SQ4
Proteomes UP000005640
Bgee Q86SQ4
CleanEx HS_GPR126
ExpressionAtlas Q86SQ4
Genevestigator Q86SQ4
GO GO:0016021
GO:0005886
GO:0004930
GO:0007186
GO:0007218
Gene3D 2.60.120.200
2.60.120.290
InterPro IPR013320
IPR000859
IPR017981
IPR000832
IPR017983
IPR000203
IPR001759
Pfam PF00002
PF00431
PF01825
PF00354
PRINTS PR00249
SMART SM00042
SM00303
SUPFAM SSF49854
SSF49899
PROSITE PS01180
PS00650
PS50261
PS50221

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0014037

Schwann cell differentiation

PMID:24227709[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019933

cAMP-mediated signaling

PMID:24227709[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:24227709[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:24227709[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0022011

myelination in peripheral nervous system

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6F3F9

P

Seeded From UniProt

complete

enables

GO:0043236

laminin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6F3F9

F

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:C6KFA3

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:C6KFA3

F

Seeded From UniProt

complete

enables

GO:0050840

extracellular matrix binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:C6KFA3

F

Seeded From UniProt

complete

enables

GO:0005518

collagen binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:C6KFA3

F

Seeded From UniProt

complete

involved_in

GO:0019933

cAMP-mediated signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:C6KFA3

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:C6KFA3

P

Seeded From UniProt

complete

involved_in

GO:0042552

myelination

PMID:26004201[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060347

heart trabecula formation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1916151
PANTHER:PTN000946704

P

Seeded From UniProt

complete

enables

GO:0043236

laminin binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1916151
PANTHER:PTN000946704

F

Seeded From UniProt

complete

involved_in

GO:0022011

myelination in peripheral nervous system

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1916151
PANTHER:PTN000946704

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1916151
PANTHER:PTN000244280
UniProtKB:Q6QNK2

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2441950
PANTHER:PTN000244280
UniProtKB:Q9HAR2
WB:WBGene00002251

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1340051
PANTHER:PTN000244280
RGD:620768
UniProtKB:O14514
UniProtKB:O60241
UniProtKB:Q6QNK2
UniProtKB:Q86SQ4
ZFIN:ZDB-GENE-041014-357

F

Seeded From UniProt

complete

involved_in

GO:0060347

heart trabecula formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6F3F9
ensembl:ENSMUSP00000043055

P

Seeded From UniProt

complete

enables

GO:0043236

laminin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6F3F9
ensembl:ENSMUSP00000043055

F

Seeded From UniProt

complete

involved_in

GO:0022011

myelination in peripheral nervous system

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6F3F9
ensembl:ENSMUSP00000043055

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6F3F9
ensembl:ENSMUSP00000043055

P

Seeded From UniProt

complete

involved_in

GO:0007005

mitochondrion organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6F3F9
ensembl:ENSMUSP00000043055

P

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR017983

F

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR017983

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR017981

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:15203201[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:15203201[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:15203201[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Mogha, A et al. (2013) Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation. J. Neurosci. 33 17976-85 PubMed GONUTS page
  2. ↑ Ravenscroft, G et al. (2015) Mutations of GPR126 are responsible for severe arthrogryposis multiplex congenita. Am. J. Hum. Genet. 96 955-61 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Bjarnadóttir, TK et al. (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics 84 23-33 PubMed GONUTS page
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