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HUMAN:GLP1R

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) GLP1R
Protein Name(s) Glucagon-like peptide 1 receptor

GLP-1 receptor GLP-1-R GLP-1R

External Links
UniProt P43220
EMBL U01104
U01157
U01156
L23503
U10037
AB065685
AY439112
AL035690
BC112126
BC113493
U66062
CCDS CCDS4839.1
PIR I84494
S71624
RefSeq NP_002053.3
XP_006715128.1
UniGene Hs.389103
PDB 3C59
3C5T
3IOL
PDBsum 3C59
3C5T
3IOL
ProteinModelPortal P43220
SMR P43220
BioGrid 109002
DIP DIP-29980N
MINT MINT-1217566
STRING 9606.ENSP00000362353
BindingDB P43220
ChEMBL CHEMBL1784
DrugBank DB01276
DB00040
DB06655
GuidetoPHARMACOLOGY 249
TCDB 9.A.14.4.6
PhosphoSite P43220
DMDM 311033387
PaxDb P43220
PRIDE P43220
DNASU 2740
Ensembl ENST00000373256
GeneID 2740
KEGG hsa:2740
UCSC uc003ooj.4
CTD 2740
GeneCards GC06P039063
H-InvDB HIX0095000
HIX0200932
HGNC HGNC:4324
MIM 138032
neXtProt NX_P43220
PharmGKB PA28725
eggNOG NOG263329
GeneTree ENSGT00760000118800
HOGENOM HOG000008250
HOVERGEN HBG008318
InParanoid P43220
KO K04581
OMA CIVVSKL
OrthoDB EOG7TF78W
PhylomeDB P43220
TreeFam TF315710
Reactome REACT_18274
REACT_18377
REACT_19327
EvolutionaryTrace P43220
GeneWiki Glucagon-like_peptide_1_receptor
GenomeRNAi 2740
NextBio 10800
PRO PR:P43220
Proteomes UP000005640
Bgee P43220
CleanEx HS_GLP1R
Genevestigator P43220
GO GO:0016021
GO:0005886
GO:0004967
GO:0004888
GO:0007190
GO:0019933
GO:0006112
GO:0007611
GO:0007204
GO:0008016
GO:0050796
GO:0006950
GO:0044281
InterPro IPR017981
IPR001879
IPR003290
IPR003292
IPR000832
IPR017983
Pfam PF00002
PF02793
PRINTS PR01353
PR01355
PR00249
SMART SM00008
PROSITE PS00649
PS00650
PS50227
PS50261

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008528

G-protein coupled peptide receptor activity

PMID:22147709[1]

ECO:0000314

F

Shown through an experiment causing mutations, the ECL2 of the GLP-1R plays a large role in GLP-1 peptide-mediated selective signaling and receptor activation. Detailed on pages 3-4

complete
CACAO 3567

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:28514449[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0044508

glucagon-like peptide 1 receptor activity

PMID:28514449[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:28514449[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0019933

cAMP-mediated signaling

PMID:7589461[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:7589461[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045777

positive regulation of blood pressure

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99571
PANTHER:PTN000946632
RGD:2703

P

Seeded From UniProt

complete

enables

GO:0017046

peptide hormone binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95710
PANTHER:PTN000244369
RGD:2669
RGD:2689
RGD:2703
RGD:3442
UniProtKB:P32241
UniProtKB:P47872
UniProtKB:Q02643
UniProtKB:Q03431
ZFIN:ZDB-GENE-991123-8

F

Seeded From UniProt

complete

enables

GO:0008528

G protein-coupled peptide receptor activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000244369
RGD:2703

F

Seeded From UniProt

complete

involved_in

GO:0071377

cellular response to glucagon stimulus

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004967

P

Seeded From UniProt

complete

involved_in

GO:1990911

response to psychosocial stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35659
ensembl:ENSMUSP00000110221

P

Seeded From UniProt

complete

involved_in

GO:0045777

positive regulation of blood pressure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35659
ensembl:ENSMUSP00000110221

P

Seeded From UniProt

complete

involved_in

GO:0008016

regulation of heart contraction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35659
ensembl:ENSMUSP00000110221

P

Seeded From UniProt

complete

involved_in

GO:0007611

learning or memory

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35659
ensembl:ENSMUSP00000110221

P

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR001879
InterPro:IPR017983
InterPro:IPR036445

F

Seeded From UniProt

complete

enables

GO:0004967

glucagon receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003290

F

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR003290
InterPro:IPR003292
InterPro:IPR017983

P

Seeded From UniProt

complete

enables

GO:0008528

G protein-coupled peptide receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003292

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001879
InterPro:IPR003290
InterPro:IPR003292
InterPro:IPR036445

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR017981

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:8405712[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007190

activation of adenylate cyclase activity

PMID:8405712[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:8405712[5]
Reactome:R-HSA-744887
Reactome:R-HSA-744886
Reactome:R-HSA-381612
Reactome:R-HSA-379044

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

PMID:8405712[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0050796

regulation of insulin secretion

Reactome:R-HSA-422356

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Koole, C et al. (2012) Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function. J. Biol. Chem. 287 3659-73 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Song, G et al. (2017) Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature 546 312-315 PubMed GONUTS page
  3. ↑ 3.0 3.1 Gromada, J et al. (1995) Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release. FEBS Lett. 373 182-6 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Thorens, B et al. (1993) Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42 1678-82 PubMed GONUTS page
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