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HUMAN:GLE1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | GLE1 (synonyms: GLE1L) | |
| Protein Name(s) | Nucleoporin GLE1
hGLE1 GLE1-like protein | |
| External Links | ||
| UniProt | Q53GS7 | |
| EMBL | AF058922 AK222842 AK222854 AL445287 AL356481 AL445287 AL356481 AL356481 AL445287 AL356481 AL445287 BC030012 AL117584 | |
| CCDS | CCDS35154.1 CCDS6904.1 | |
| PIR | T17316 | |
| RefSeq | NP_001003722.1 NP_001490.1 | |
| UniGene | Hs.522418 | |
| ProteinModelPortal | Q53GS7 | |
| SMR | Q53GS7 | |
| BioGrid | 108995 | |
| IntAct | Q53GS7 | |
| MINT | MINT-4535009 | |
| STRING | 9606.ENSP00000308622 | |
| TCDB | 1.I.1.1.3 3.A.18.1.1 | |
| iPTMnet | Q53GS7 | |
| PhosphoSitePlus | Q53GS7 | |
| BioMuta | GLE1 | |
| DMDM | 83288218 | |
| EPD | Q53GS7 | |
| MaxQB | Q53GS7 | |
| PaxDb | Q53GS7 | |
| PeptideAtlas | Q53GS7 | |
| PRIDE | Q53GS7 | |
| DNASU | 2733 | |
| Ensembl | ENST00000309971 ENST00000372770 | |
| GeneID | 2733 | |
| KEGG | hsa:2733 | |
| UCSC | uc004bvi.4 | |
| CTD | 2733 | |
| DisGeNET | 2733 | |
| GeneCards | GLE1 | |
| HGNC | HGNC:4315 | |
| HPA | HPA041689 HPA043538 HPA061560 | |
| MalaCards | GLE1 | |
| MIM | 253310 603371 611890 | |
| neXtProt | NX_Q53GS7 | |
| OpenTargets | ENSG00000119392 | |
| Orphanet | 53696 1486 | |
| PharmGKB | PA28718 | |
| eggNOG | KOG2412 ENOG410XT57 | |
| GeneTree | ENSGT00390000012903 | |
| HOGENOM | HOG000246966 | |
| HOVERGEN | HBG081558 | |
| InParanoid | Q53GS7 | |
| KO | K18723 | |
| OMA | GNQLCSQ | |
| OrthoDB | EOG091G0AZV | |
| PhylomeDB | Q53GS7 | |
| TreeFam | TF324158 | |
| ChiTaRS | GLE1 | |
| GeneWiki | GLE1L | |
| GenomeRNAi | 2733 | |
| PRO | PR:Q53GS7 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000119392 | |
| CleanEx | HS_GLE1 | |
| Genevisible | Q53GS7 | |
| GO | GO:0005737 GO:0005829 GO:0005615 GO:0016020 GO:0031965 GO:0005643 GO:0044614 GO:0005730 GO:0042802 GO:0000822 GO:0005543 GO:0031369 GO:0006406 GO:0016973 GO:0006446 GO:0006449 | |
| InterPro | IPR012476 | |
| PANTHER | PTHR12960 | |
| Pfam | PF07817 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001827) |
Seeded From UniProt |
complete | ||
| GO:0036064 |
ciliary basal body |
ECO:0000314 |
C |
Figure 1 Part B shows localization of Gle1 to the ciliary base's ciliary basal body. The gene is referred to as Gle1 by both UniProt and the experiment, and the organism for the gene is human and was expressed in Danio rerio (Zebrafish). |
complete | |||||
|
part_of |
GO:0044614 |
nuclear pore cytoplasmic filaments |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
C |
Seeded From UniProt |
complete | ||
| GO:0005635 |
nuclear envelope |
ECO:0000314 |
C |
Figure 1 Part A shows Gle1 localization at the nuclear envelope indicated by the arrow pointing with "NE." The organism for the gene is human and was expressed in Danio rerio (Zebrafish). The gene is referred to as Gle1 by both UniProt and the experiment. |
complete | |||||
|
enables |
GO:0031369 |
translation initiation factor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
F |
Seeded From UniProt |
complete | ||
| GO:0005814 |
centriole |
ECO:0000314 |
C |
Figure 2 Part A shows localization of Gle1 in centrioles, with brighter CETN signals showing older ("mother") centriole localization. The gene is referred to as Gle1 by both UniProt and the experiment, and the organism for the gene is human and was expressed in Danio rerio (Zebrafish). |
complete | |||||
|
involved_in |
GO:0006449 |
regulation of translational termination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
P |
Seeded From UniProt |
complete | ||
| GO:0005813 |
centrosome |
ECO:0000314 |
C |
Figure 1 Part A shows Gle1 localization at the centrosome indicated by the arrow pointing with "Ce." The organism for the gene is human and was expressed in Danio rerio (Zebrafish). The gene is referred to as Gle1 by both UniProt and the experiment. |
complete | |||||
|
involved_in |
GO:0006446 |
regulation of translational initiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006406 |
mRNA export from nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005543 |
phospholipid binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000822 |
inositol hexakisphosphate binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005643 |
nuclear pore |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016973 |
poly(A)+ mRNA export from nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006406 |
mRNA export from nucleus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005643 |
nuclear pore |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005643 |
nuclear pore |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051028 |
mRNA transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Jao, LE et al. (2017) A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. Mol. Biol. Cell 28 120-127 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Folkmann, AW et al. (2013) Gle1 functions during mRNA export in an oligomeric complex that is altered in human disease. Cell 155 582-93 PubMed GONUTS page
- ↑ 6.0 6.1 Watkins, JL et al. (1998) The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export. Proc. Natl. Acad. Sci. U.S.A. 95 6779-84 PubMed GONUTS page
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