HUMAN:GDE

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	AGL (synonyms: GDE)
Protein Name(s)	Glycogen debranching enzyme Glycogen debrancher 4-alpha-glucanotransferase Oligo-1,4-1,4-glucantransferase Amylo-alpha-1,6-glucosidase Amylo-1,6-glucosidase Dextrin 6-alpha-D-glucosidase
External Links
UniProt	P35573
EMBL	M85168 U84007 U84008 U84009 U84010 U84011 AB035443 AB208867 AC096949 CH471097 CH471097 CH471097 CH471097 BC078663
CCDS	CCDS759.1 CCDS760.1 CCDS761.1
RefSeq	NP_000019.2 NP_000633.2 NP_000634.2 NP_000635.2 NP_000636.2 NP_000637.2 XP_005270614.1
UniGene	Hs.904
ProteinModelPortal	P35573
SMR	P35573
BioGrid	106686
IntAct	P35573
MINT	MINT-2802883
STRING	9606.ENSP00000294724
BindingDB	P35573
ChEMBL	CHEMBL5272
CAZy	GH13
PhosphoSite	P35573
DMDM	116242491
MaxQB	P35573
PaxDb	P35573
PRIDE	P35573
Ensembl	ENST00000294724 ENST00000361302 ENST00000361522 ENST00000361915 ENST00000370161 ENST00000370163 ENST00000370165
GeneID	178
KEGG	hsa:178
UCSC	uc001dsi.1 uc001dsm.1 uc001dsn.1
CTD	178
GeneCards	GC01P100315
GeneReviews	AGL
HGNC	HGNC:321
HPA	HPA028498
MIM	232400 610860
neXtProt	NX_P35573
Orphanet	366
PharmGKB	PA24618
eggNOG	COG3408
GeneTree	ENSGT00390000012596
HOVERGEN	HBG005824
InParanoid	P35573
KO	K01196
OMA	PCLRPLM
OrthoDB	EOG7C5M7F
PhylomeDB	P35573
TreeFam	TF300697
BioCyc	MetaCyc:HS08717-MONOMER
Reactome	REACT_1008
GeneWiki	Glycogen_debranching_enzyme
GenomeRNAi	178
NextBio	722
PRO	PR:P35573
Proteomes	UP000005640
Bgee	P35573
CleanEx	HS_AGL
ExpressionAtlas	P35573
Genevestigator	P35573
GO	GO:0005737 GO:0005829 GO:0016234 GO:0043033 GO:0005634 GO:0016529 GO:0004134 GO:0004135 GO:0004133 GO:0030247 GO:0005975 GO:0006006 GO:0005978 GO:0005980 GO:0051384 GO:0007584 GO:0044281
Gene3D	3.20.20.80
InterPro	IPR008928 IPR010401 IPR029436 IPR013781 IPR006421 IPR017853
PANTHER	PTHR10569
Pfam	PF06202 PF14699
SUPFAM	SSF48208 SSF51445
TIGRFAMs	TIGR01531

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005737	cytoplasm	PMID:17908927^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0005980	glycogen catabolic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000060165 RGD:1306376 SGD:S000006388	P	Seeded From UniProt	complete
enables	GO:0004135	amylo-alpha-1,6-glucosidase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000060165 RGD:1306376 SGD:S000006388 UniProtKB:P35573	F	Seeded From UniProt	complete
enables	GO:0004134	4-alpha-glucanotransferase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000060165 RGD:1306376 SGD:S000006388 UniProtKB:P35573	F	Seeded From UniProt	complete
enables	GO:0004135	amylo-alpha-1,6-glucosidase activity	PMID:2961257^[3]	ECO:0000269	experimental evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004134	4-alpha-glucanotransferase activity	PMID:2961257^[3]	ECO:0000269	experimental evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AEH9 ensembl:ENSRNOP00000052593	P	Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AEH9 ensembl:ENSRNOP00000052593	F	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AEH9 ensembl:ENSRNOP00000052593	C	Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AEH9 ensembl:ENSRNOP00000052593	P	Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AEH9 ensembl:ENSRNOP00000052593	P	Seeded From UniProt	complete
involved_in	GO:0005980	glycogen catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AEH9 ensembl:ENSRNOP00000052593	P	Seeded From UniProt	complete
enables	GO:0004135	amylo-alpha-1,6-glucosidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AEH9 ensembl:ENSRNOP00000052593	F	Seeded From UniProt	complete
enables	GO:0004134	4-alpha-glucanotransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AEH9 ensembl:ENSRNOP00000052593	F	Seeded From UniProt	complete
enables	GO:0031593	polyubiquitin modification-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F8VPN4 ensembl:ENSMUSP00000044012	F	Seeded From UniProt	complete
enables	GO:0030247	polysaccharide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F8VPN4 ensembl:ENSMUSP00000044012	F	Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F8VPN4 ensembl:ENSMUSP00000044012	C	Seeded From UniProt	complete
involved_in	GO:0005977	glycogen metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F8VPN4 ensembl:ENSMUSP00000044012	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F8VPN4 ensembl:ENSMUSP00000044012	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F8VPN4 ensembl:ENSMUSP00000044012	C	Seeded From UniProt	complete
enables	GO:0004133	glycogen debranching enzyme activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F8VPN4 ensembl:ENSMUSP00000044012	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008928	F	Seeded From UniProt	complete
enables	GO:0004134	4-alpha-glucanotransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006421 InterPro:IPR010401	F	Seeded From UniProt	complete
enables	GO:0004135	amylo-alpha-1,6-glucosidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006421 InterPro:IPR010401	F	Seeded From UniProt	complete
involved_in	GO:0005978	glycogen biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006421	P	Seeded From UniProt	complete
involved_in	GO:0005980	glycogen catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010401	P	Seeded From UniProt	complete
enables	GO:0004134	4-alpha-glucanotransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.1.25	F	Seeded From UniProt	complete
enables	GO:0004135	amylo-alpha-1,6-glucosidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.2.1.33	F	Seeded From UniProt	complete
enables	GO:0102500	beta-maltose 4-alpha-glucanotransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.1.25	F	Seeded From UniProt	complete
part_of	GO:0043033	isoamylase complex	PMID:1374391^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004133	glycogen debranching enzyme activity	PMID:1374391^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:1904813	ficolin-1-rich granule lumen	Reactome:R-HSA-6800434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0005980	glycogen catabolic process	Reactome:R-HSA-70221	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-71593 Reactome:R-HSA-71552	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6800434 Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0326 UniProtKB-KW:KW-0511	P	Seeded From UniProt	complete
enables	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0328	F	Seeded From UniProt	complete
enables	GO:0016798	hydrolase activity, acting on glycosyl bonds	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0326	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0005978	glycogen biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0320	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Cheng, A et al. (2007) A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 21 2399-409 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Chen, YT et al. (1987) Glycogen debranching enzyme: purification, antibody characterization, and immunoblot analyses of type III glycogen storage disease. Am. J. Hum. Genet. 41 1002-15 PubMed GONUTS page
↑ ^4.0 ^4.1 Yang, BZ et al. (1992) Molecular cloning and nucleotide sequence of cDNA encoding human muscle glycogen debranching enzyme. J. Biol. Chem. 267 9294-9 PubMed GONUTS page

[PMID:17908927-1] Cheng, A et al. (2007) A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 21 2399-409 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2961257-3] 3.0 ^3.1 Chen, YT et al. (1987) Glycogen debranching enzyme: purification, antibody characterization, and immunoblot analyses of type III glycogen storage disease. Am. J. Hum. Genet. 41 1002-15 PubMed GONUTS page

[PMID:1374391-4] 4.0 ^4.1 Yang, BZ et al. (1992) Molecular cloning and nucleotide sequence of cDNA encoding human muscle glycogen debranching enzyme. J. Biol. Chem. 267 9294-9 PubMed GONUTS page

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HUMAN:GDE

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