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HUMAN:FXR2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | FXR2 (synonyms: FMR1L2) | |
| Protein Name(s) | Fragile X mental retardation syndrome-related protein 2 | |
| External Links | ||
| UniProt | P51116 | |
| EMBL | U31501 BT009817 AK313836 CH471108 CH471108 BC020090 BC051907 BC067272 AF044263 | |
| CCDS | CCDS45604.1 | |
| PIR | S60173 | |
| RefSeq | NP_004851.2 | |
| UniGene | Hs.52788 | |
| PDB | 3H8Z | |
| PDBsum | 3H8Z | |
| ProteinModelPortal | P51116 | |
| SMR | P51116 | |
| BioGrid | 114890 | |
| IntAct | P51116 | |
| MINT | MINT-108243 | |
| STRING | 9606.ENSP00000250113 | |
| PhosphoSite | P51116 | |
| DMDM | 90177782 | |
| MaxQB | P51116 | |
| PaxDb | P51116 | |
| PRIDE | P51116 | |
| DNASU | 9513 | |
| Ensembl | ENST00000250113 | |
| GeneID | 9513 | |
| KEGG | hsa:9513 | |
| UCSC | uc002gia.2 | |
| CTD | 9513 | |
| GeneCards | GC17M007494 | |
| HGNC | HGNC:4024 | |
| HPA | CAB011205 HPA022997 | |
| MIM | 605339 | |
| neXtProt | NX_P51116 | |
| PharmGKB | PA28440 | |
| eggNOG | NOG75351 | |
| GeneTree | ENSGT00390000017033 | |
| HOGENOM | HOG000293377 | |
| HOVERGEN | HBG005739 | |
| InParanoid | P51116 | |
| KO | K15516 | |
| OMA | FRSIRTK | |
| OrthoDB | EOG7NKKJT | |
| PhylomeDB | P51116 | |
| TreeFam | TF105427 | |
| ChiTaRS | FXR2 | |
| EvolutionaryTrace | P51116 | |
| GeneWiki | FXR2 | |
| GenomeRNAi | 9513 | |
| NextBio | 35646 | |
| PRO | PR:P51116 | |
| Proteomes | UP000005640 | |
| Bgee | P51116 | |
| CleanEx | HS_FXR2 | |
| ExpressionAtlas | P51116 | |
| Genevestigator | P51116 | |
| GO | GO:0005737 GO:0022625 GO:0070062 GO:0016020 GO:0042802 GO:0044822 GO:0003723 | |
| Gene3D | 3.30.1370.10 | |
| InterPro | IPR008395 IPR022034 IPR004087 IPR004088 | |
| Pfam | PF05641 PF12235 PF00013 | |
| SMART | SM00322 | |
| SUPFAM | SSF54791 | |
| PROSITE | PS51641 PS50084 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Figure 6 |
complete | |||||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045727 |
positive regulation of translation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95564 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0045182 |
translation regulator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0028734 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043488 |
regulation of mRNA stability |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95564 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043197 |
dendritic spine |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104860 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0028734 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001318100 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0036464 |
cytoplasmic ribonucleoprotein granule |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95564 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035770 |
ribonucleoprotein granule |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104860 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030424 |
axon |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104860 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0017148 |
negative regulation of translation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0028734 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000063980 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005844 |
polysome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104860 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0028734 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104860 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003730 |
mRNA 3'-UTR binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104860 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95564 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006417 |
regulation of translation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0022625 |
cytosolic large ribosomal subunit |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Zhang, Y et al. (1995) The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. EMBO J. 14 5358-66 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
- ↑ Sjekloća, L et al. (2011) On the aggregation properties of FMRP--a link with the FXTAS syndrome? FEBS J. 278 1912-21 PubMed GONUTS page
- ↑ Rual, JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 1173-8 PubMed GONUTS page
- ↑ 9.0 9.1 Tamanini, F et al. (1997) Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis. Hum. Mol. Genet. 6 1315-22 PubMed GONUTS page
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