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HUMAN:FTMT

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FTMT
Protein Name(s) Ferritin, mitochondrial
External Links
UniProt Q8N4E7
EMBL BC034419
CCDS CCDS4128.1
RefSeq NP_803431.1
UniGene Hs.105324
PDB 1R03
PDBsum 1R03
ProteinModelPortal Q8N4E7
SMR Q8N4E7
STRING 9606.ENSP00000313691
DMDM 62900307
PaxDb Q8N4E7
PRIDE Q8N4E7
DNASU 94033
Ensembl ENST00000321339
GeneID 94033
KEGG hsa:94033
UCSC uc003kss.3
CTD 94033
GeneCards GC05P121187
HGNC HGNC:17345
MIM 608847
neXtProt NX_Q8N4E7
PharmGKB PA134941146
eggNOG COG1528
GeneTree ENSGT00760000119129
HOGENOM HOG000223383
HOVERGEN HBG000410
InParanoid Q8N4E7
KO K18495
OMA FLETYYL
OrthoDB EOG7DRJ49
PhylomeDB Q8N4E7
TreeFam TF313885
EvolutionaryTrace Q8N4E7
GeneWiki Mitochondrial_ferritin
GenomeRNAi 94033
NextBio 78343
PRO PR:Q8N4E7
Proteomes UP000005640
Bgee Q8N4E7
CleanEx HS_FTMT
Genevestigator Q8N4E7
GO GO:0005739
GO:0005634
GO:0008199
GO:0004322
GO:0006879
GO:0006826
GO:0008284
GO:0051349
GO:0051353
GO:0051347
Gene3D 1.20.1260.10
InterPro IPR001519
IPR009040
IPR009078
IPR012347
IPR014034
IPR008331
PANTHER PTHR11431
Pfam PF00210
SUPFAM SSF47240
PROSITE PS00204
PS50905

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1904231

positive regulation of succinate dehydrogenase activity

PMID:18160053[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q16595

P

Seeded From UniProt

complete

involved_in

GO:1904234

positive regulation of aconitate hydratase activity

PMID:18160053[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q16595

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

involved_in

GO:0051349

positive regulation of lyase activity

PMID:18160053[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:18160053[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

PMID:18160053[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10921
PANTHER:PTN000153092
UniProtKB:P02792
WB:WBGene00001500
WB:WBGene00001501

F

Seeded From UniProt

complete

enables

GO:0008199

ferric iron binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10921
PANTHER:PTN000153092

F

Seeded From UniProt

complete

enables

GO:0008198

ferrous iron binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000153092
UniProtKB:A0A0B4KHF0
UniProtKB:A0A0B4KI27

F

Seeded From UniProt

complete

involved_in

GO:0006880

intracellular sequestering of iron ion

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10921
PANTHER:PTN000153092
UniProtKB:P02794
UniProtKB:P9WNE5

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000153092
RGD:61813

C

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95588
PANTHER:PTN000153092
UniProtKB:P02792

F

Seeded From UniProt

complete

enables

GO:0004322

ferroxidase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10921
PANTHER:PTN000153092
UniProtKB:P9WNE5

F

Seeded From UniProt

complete

involved_in

GO:0006826

iron ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001519

P

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001519
InterPro:IPR008331

P

Seeded From UniProt

complete

enables

GO:0008199

ferric iron binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001519
InterPro:IPR008331

F

Seeded From UniProt

complete

enables

GO:0004322

ferroxidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.16.3.1

F

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

Reactome:R-HSA-917937

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

Reactome:R-HSA-5691107

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0409

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Zanella, I et al. (2008) The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin. Biochim. Biophys. Acta 1782 90-8 PubMed GONUTS page
  2. de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page