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HUMAN:FR1OP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FGFR1OP (synonyms: FOP)
Protein Name(s) FGFR1 oncogene partner
External Links
UniProt O95684
EMBL Y18046
AK289846
AK312791
Z94721
Z94721
CH471051
CH471051
BC011902
BC037785
CCDS CCDS5296.1
CCDS5297.1
RefSeq NP_008976.1
NP_919410.1
UniGene Hs.487175
PDB 2D68
PDBsum 2D68
ProteinModelPortal O95684
SMR O95684
BioGrid 116291
IntAct O95684
MINT MINT-8214435
STRING 9606.ENSP00000355812
iPTMnet O95684
PhosphoSitePlus O95684
BioMuta FGFR1OP
EPD O95684
MaxQB O95684
PaxDb O95684
PeptideAtlas O95684
PRIDE O95684
DNASU 11116
Ensembl ENST00000349556
ENST00000366847
GeneID 11116
KEGG hsa:11116
UCSC uc003qvj.5
CTD 11116
DisGeNET 11116
EuPathDB HostDB:ENSG00000213066.11
GeneCards FGFR1OP
HGNC HGNC:17012
HPA HPA071876
MIM 605392
neXtProt NX_O95684
OpenTargets ENSG00000213066
PharmGKB PA134941638
eggNOG ENOG410IH12
ENOG4111J6Y
GeneTree ENSGT00390000007441
HOGENOM HOG000007633
HOVERGEN HBG081536
InParanoid O95684
KO K16546
OMA KIPRYKG
OrthoDB EOG091G0V88
PhylomeDB O95684
TreeFam TF331893
Reactome [www.reactome.org/content/detail/R-HSA-1839117 R-HSA-1839117]
[www.reactome.org/content/detail/R-HSA-2565942 R-HSA-2565942]
[www.reactome.org/content/detail/R-HSA-380259 R-HSA-380259]
[www.reactome.org/content/detail/R-HSA-380270 R-HSA-380270]
[www.reactome.org/content/detail/R-HSA-380284 R-HSA-380284]
[www.reactome.org/content/detail/R-HSA-380320 R-HSA-380320]
[www.reactome.org/content/detail/R-HSA-5620912 R-HSA-5620912]
[www.reactome.org/content/detail/R-HSA-5655302 R-HSA-5655302]
[www.reactome.org/content/detail/R-HSA-8854518 R-HSA-8854518]
SIGNOR O95684
ChiTaRS FGFR1OP
EvolutionaryTrace O95684
GeneWiki FGFR1OP
GenomeRNAi 11116
PRO PR:O95684
Proteomes UP000005640
Bgee ENSG00000213066
CleanEx HS_FGFR1OP
ExpressionAtlas O95684
Genevisible O95684
GO GO:0042995
GO:0005814
GO:0005813
GO:0005829
GO:0005634
GO:0048471
GO:0042803
GO:0019901
GO:0004713
GO:0030292
GO:0097711
GO:0000086
GO:0034453
GO:0006469
GO:0030307
GO:0030335
GO:0008284
GO:0010389
InterPro IPR018993
IPR006594
Pfam PF09398
PROSITE PS50896

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:17888034[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:16690081[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:17888034[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030307

positive regulation of cell growth

PMID:17888034[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030292

protein tyrosine kinase inhibitor activity

PMID:17888034[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:17888034[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P00519

F

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:17888034[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006469

negative regulation of protein kinase activity

PMID:17888034[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21399614[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:16690081[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:17888034[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17888034[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0061099

negative regulation of protein tyrosine kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0030292

P

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018993

C

Seeded From UniProt

complete

involved_in

GO:0034453

microtubule anchoring

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018993

P

Seeded From UniProt

complete

involved_in

GO:0097711

ciliary basal body-plasma membrane docking

Reactome:R-HSA-5620912

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010389

regulation of G2/M transition of mitotic cell cycle

Reactome:R-HSA-8854518

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8853419
Reactome:R-HSA-8853405
Reactome:R-HSA-5638009
Reactome:R-HSA-5626699
Reactome:R-HSA-5626681
Reactome:R-HSA-5626228
Reactome:R-HSA-5626227
Reactome:R-HSA-5626223
Reactome:R-HSA-5626220
Reactome:R-HSA-5617816
Reactome:R-HSA-380508
Reactome:R-HSA-380455
Reactome:R-HSA-380316
Reactome:R-HSA-380311
Reactome:R-HSA-380303
Reactome:R-HSA-380294
Reactome:R-HSA-380283
Reactome:R-HSA-380272
Reactome:R-HSA-3000319
Reactome:R-HSA-3000310
Reactome:R-HSA-2574845
Reactome:R-HSA-2574840
Reactome:R-HSA-1888198
Reactome:R-HSA-1839100
Reactome:R-HSA-1839098
Reactome:R-HSA-1839094
Reactome:R-HSA-1839091
Reactome:R-HSA-1839080
Reactome:R-HSA-1839078
Reactome:R-HSA-1839065
Reactome:R-HSA-1839039
Reactome:R-HSA-1839031

ECO:0000304

author statement supported by traceable reference used in manual assertion
































C

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

Reactome:R-HSA-69275

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030030

cell projection organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0970

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0046

C

Seeded From UniProt

complete

GO:0005814

centriole

PMID:23554904[4]

ECO:0000314

C

Human; FGFR1 oncogene partner (FOP)

According to Figure 1A and S1, FOP localizes to centrioles at all cell stages.

complete
CACAO 13037

GO:0034451

centriolar satellite

PMID:23554904[4]

ECO:0000314

C

Human; FGFR1 oncogene partner (FOP)

According to figure 1B and 1C, FOP localizes to centriolar satellites in all cell stages except for G1.

complete
CACAO 13040

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Mano, Y et al. (2007) Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. Cancer Sci. 98 1902-13 PubMed GONUTS page
  2. ↑ 2.0 2.1 Mikolajka, A et al. (2006) Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. J. Mol. Biol. 359 863-75 PubMed GONUTS page
  3. ↑ Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
  4. ↑ 4.0 4.1 Lee, JY & Stearns, T (2013) FOP is a centriolar satellite protein involved in ciliogenesis. PLoS ONE 8 e58589 PubMed GONUTS page
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