GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:FKTN
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | FKTN (synonyms: FCMD) | |
| Protein Name(s) | Fukutin
Fukuyama-type congenital muscular dystrophy protein | |
| External Links | ||
| UniProt | O75072 | |
| EMBL | AB008226 AB038490 AK300840 AL158070 BC101808 BC112038 BC117699 | |
| CCDS | CCDS6766.1 | |
| RefSeq | NP_001073270.1 NP_001185892.1 NP_006722.2 XP_005251860.1 XP_005251861.1 | |
| UniGene | Hs.55777 | |
| ProteinModelPortal | O75072 | |
| BioGrid | 108512 | |
| STRING | 9606.ENSP00000223528 | |
| PhosphoSite | O75072 | |
| MaxQB | O75072 | |
| PaxDb | O75072 | |
| PRIDE | O75072 | |
| DNASU | 2218 | |
| Ensembl | ENST00000223528 ENST00000357998 ENST00000448551 ENST00000602661 | |
| GeneID | 2218 | |
| KEGG | hsa:2218 | |
| UCSC | uc004bcr.3 | |
| CTD | 2218 | |
| GeneCards | GC09P108320 | |
| GeneReviews | FKTN | |
| HGNC | HGNC:3622 | |
| HPA | HPA012820 | |
| MIM | 253800 607440 611588 611615 613152 | |
| neXtProt | NX_O75072 | |
| Orphanet | 206554 370980 272 154 588 899 | |
| PharmGKB | PA162388669 | |
| eggNOG | NOG83383 | |
| GeneTree | ENSGT00390000014471 | |
| HOGENOM | HOG000231657 | |
| HOVERGEN | HBG005068 | |
| InParanoid | O75072 | |
| OMA | PVKTWDW | |
| OrthoDB | EOG7M6D86 | |
| PhylomeDB | O75072 | |
| TreeFam | TF319633 | |
| UniPathway | UPA00378 | |
| ChiTaRS | FKTN | |
| GeneWiki | Fukutin | |
| GenomeRNAi | 2218 | |
| NextBio | 35535038 | |
| PRO | PR:O75072 | |
| Proteomes | UP000005640 | |
| Bgee | O75072 | |
| CleanEx | HS_FKTN | |
| ExpressionAtlas | O75072 | |
| Genevestigator | O75072 | |
| GO | GO:0005801 GO:0005783 GO:0005615 GO:0005794 GO:0000139 GO:0016021 GO:0005634 GO:0016740 GO:0007517 GO:0008285 GO:0046329 GO:0007399 GO:0060049 | |
| InterPro | IPR009644 IPR007074 | |
| PANTHER | PTHR15407 | |
| Pfam | PF04991 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006493 |
protein O-linked glycosylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030173 |
integral component of Golgi membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035269 |
protein O-linked mannosylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060049 |
regulation of protein glycosylation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046329 |
negative regulation of JNK cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005801 |
cis-Golgi network |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R507 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007517 |
muscle organ development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000139 |
Golgi membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006486 |
protein glycosylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00378 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Xiong, H et al. (2006) Molecular interaction between fukutin and POMGnT1 in the glycosylation pathway of alpha-dystroglycan. Biochem. Biophys. Res. Commun. 350 935-41 PubMed GONUTS page
- ↑ 2.0 2.1 Willer, T et al. (2014) The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation. Elife 3 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Yamamoto, T et al. (2008) A role of fukutin, a gene responsible for Fukuyama type congenital muscular dystrophy, in cancer cells: a possible role to suppress cell proliferation. Int J Exp Pathol 89 332-41 PubMed GONUTS page
- ↑ Matsumoto, H et al. (2004) Subcellular localization of fukutin and fukutin-related protein in muscle cells. J. Biochem. 135 709-12 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Kobayashi, K et al. (1998) An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature 394 388-92 PubMed GONUTS page
e
n
p
