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HUMAN:FKBP5
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | FKBP5 (synonyms: AIG6, FKBP51) | |
| Protein Name(s) | Peptidyl-prolyl cis-trans isomerase FKBP5
PPIase FKBP5 51 kDa FK506-binding protein 51 kDa FKBP FKBP-51 54 kDa progesterone receptor-associated immunophilin Androgen-regulated protein 6 FF1 antigen FK506-binding protein 5 FKBP-5 FKBP54 p54 HSP90-binding immunophilin Rotamase | |
| External Links | ||
| UniProt | Q13451 | |
| EMBL | U71321 AF194172 AK312422 AB209893 AL033519 AL157823 AL590400 CH471081 BC042605 U42031 | |
| CCDS | CCDS4808.1 CCDS54996.1 | |
| PIR | JC5422 | |
| RefSeq | NP_001139247.1 NP_001139248.1 NP_001139249.1 NP_004108.1 | |
| UniGene | Hs.407190 | |
| PDB | 1KT0 3O5D 3O5E 3O5F 3O5G 3O5I 3O5J 3O5K 3O5L 3O5M 3O5O 3O5P 3O5Q 3O5R 4DRH 4DRI 4DRK 4DRM 4DRN 4DRO 4DRP 4DRQ 4JFI 4JFJ 4JFK 4JFL 4JFM 4TX0 | |
| PDBsum | 1KT0 3O5D 3O5E 3O5F 3O5G 3O5I 3O5J 3O5K 3O5L 3O5M 3O5O 3O5P 3O5Q 3O5R 4DRH 4DRI 4DRK 4DRM 4DRN 4DRO 4DRP 4DRQ 4JFI 4JFJ 4JFK 4JFL 4JFM 4TX0 | |
| ProteinModelPortal | Q13451 | |
| SMR | Q13451 | |
| BioGrid | 108579 | |
| DIP | DIP-27597N | |
| IntAct | Q13451 | |
| MINT | MINT-1142816 | |
| STRING | 9606.ENSP00000338160 | |
| BindingDB | Q13451 | |
| ChEMBL | CHEMBL2052031 | |
| PhosphoSite | Q13451 | |
| DMDM | 2851536 | |
| MaxQB | Q13451 | |
| PaxDb | Q13451 | |
| PRIDE | Q13451 | |
| DNASU | 2289 | |
| Ensembl | ENST00000357266 ENST00000536438 ENST00000539068 ENST00000542713 | |
| GeneID | 2289 | |
| KEGG | hsa:2289 | |
| UCSC | uc003okx.2 | |
| CTD | 2289 | |
| GeneCards | GC06M035541 | |
| HGNC | HGNC:3721 | |
| HPA | CAB009315 HPA031092 HPA031093 HPA031095 | |
| MIM | 602623 | |
| neXtProt | NX_Q13451 | |
| PharmGKB | PA28162 | |
| eggNOG | COG0545 | |
| GeneTree | ENSGT00760000119159 | |
| HOGENOM | HOG000256916 | |
| HOVERGEN | HBG051624 | |
| InParanoid | Q13451 | |
| KO | K09571 | |
| OMA | NSEETPM | |
| OrthoDB | EOG725DHH | |
| PhylomeDB | Q13451 | |
| TreeFam | TF105292 | |
| ChiTaRS | FKBP5 | |
| EvolutionaryTrace | Q13451 | |
| GeneWiki | FKBP5 | |
| GenomeRNAi | 2289 | |
| NextBio | 9303 | |
| PRO | PR:Q13451 | |
| Proteomes | UP000005640 | |
| Bgee | Q13451 | |
| CleanEx | HS_FKBP5 | |
| ExpressionAtlas | Q13451 | |
| Genevestigator | Q13451 | |
| GO | GO:0005789 GO:0070062 GO:0016020 GO:0005634 GO:0005528 GO:0031072 GO:0003755 GO:0061077 GO:0006457 GO:0000413 | |
| Gene3D | 1.10.150.160 1.25.40.10 | |
| InterPro | IPR023114 IPR023566 IPR001179 IPR013026 IPR011990 IPR001440 IPR019734 | |
| PANTHER | PTHR10516 | |
| Pfam | PF00254 PF00515 | |
| PROSITE | PS50059 PS50005 PS50293 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061077 |
chaperone-mediated protein folding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061077 |
chaperone-mediated protein folding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000054102 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000054102 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
CGD:CAL0000188340 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000413 |
protein peptidyl-prolyl isomerization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000054102 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009617 |
response to bacterium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64378 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000413 |
protein peptidyl-prolyl isomerization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005528 |
FK506 binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006457 |
protein folding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005528 |
FK506 binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-5618105 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016853 |
isomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ 3.0 3.1 Pirkl, F & Buchner, J (2001) Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. J. Mol. Biol. 308 795-806 PubMed GONUTS page
- ↑ Young, JC et al. (1998) Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. J. Biol. Chem. 273 18007-10 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 6.0 6.1 Nair, SC et al. (1997) Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. Mol. Cell. Biol. 17 594-603 PubMed GONUTS page
