HUMAN:FGFR1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FGFR1 (synonyms: BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR)
Protein Name(s)	Fibroblast growth factor receptor 1 FGFR-1 Basic fibroblast growth factor receptor 1 BFGFR bFGF-R-1 Fms-like tyrosine kinase 2 FLT-2 N-sam Proto-oncogene c-Fgr
External Links
UniProt	P11362
EMBL	M37722 X52833 M34185 M34186 M34187 M34188 X51803 M34641 M60485 X57118 X57119 X57120 X57121 X57122 M63887 M63888 M63889 X66945 FJ809917 AK291754 AK292470 AK309947 AB208919 AK222718 AY585209 AC087623 BC015035 BC018128 BC091494 Y00665
CCDS	CCDS43730.1 CCDS43731.1 CCDS43732.1 CCDS55221.1 CCDS55222.1 CCDS55223.1 CCDS6107.2
PIR	A41266 C36464 C40862 S11692 S19167
RefSeq	NP_001167534.1 NP_001167535.1 NP_001167536.1 NP_001167537.1 NP_001167538.1 NP_056934.2 NP_075593.1 NP_075594.1 NP_075598.2
UniGene	Hs.264887
PDB	1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 1XR0 2CR3 2FGI 3C4F 3DPK 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3OJV 3RHX 3TT0 3WJ6 4F63 4F64 4F65 4NK9 4NKA 4NKS
PDBsum	1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 1XR0 2CR3 2FGI 3C4F 3DPK 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3OJV 3RHX 3TT0 3WJ6 4F63 4F64 4F65 4NK9 4NKA 4NKS
ProteinModelPortal	P11362
SMR	P11362
BioGrid	108551
DIP	DIP-4019N
IntAct	P11362
MINT	MINT-1499363
BindingDB	P11362
ChEMBL	CHEMBL2095217
DrugBank	DB00039 DB08901 DB08896 DB00398
GuidetoPHARMACOLOGY	1808
PhosphoSite	P11362
DMDM	120046
MaxQB	P11362
PaxDb	P11362
PRIDE	P11362
DNASU	2260
Ensembl	ENST00000326324 ENST00000335922 ENST00000356207 ENST00000397091 ENST00000397108 ENST00000397113 ENST00000425967 ENST00000447712 ENST00000484370 ENST00000532791
GeneID	2260
KEGG	hsa:2260
UCSC	uc003xlp.3 uc003xlu.3 uc003xlv.3 uc010lwk.3 uc011lbu.2 uc011lbv.2 uc011lbw.2 uc022aua.1 uc022aud.1
CTD	2260
GeneCards	GC08M038268
GeneReviews	FGFR1
HGNC	HGNC:3688
HPA	CAB033614 HPA056402
MIM	101600 136350 147950 166250 190440 615465
neXtProt	NX_P11362
Orphanet	251579 251576 2117 2227 3366 478 168953 432 99798 2645 93258 251612 3157
PharmGKB	PA28127
eggNOG	COG0515
GeneTree	ENSGT00760000118923
HOGENOM	HOG000263410
HOVERGEN	HBG000345
InParanoid	P11362
KO	K04362
OMA	IVYKMKS
OrthoDB	EOG7NGQ9N
PhylomeDB	P11362
TreeFam	TF316307
BRENDA	2.7.10.1
Reactome	REACT_111184 REACT_120827 REACT_121153 REACT_121398 REACT_147727 REACT_18334 REACT_21247 REACT_21270 REACT_21310 REACT_21374 REACT_22272 REACT_75829 REACT_9484 REACT_9515 REACT_976
SignaLink	P11362
ChiTaRS	FGFR1
EvolutionaryTrace	P11362
GeneWiki	Fibroblast_growth_factor_receptor_1
GenomeRNAi	2260
NextBio	9163
PMAP-CutDB	P11362
PRO	PR:P11362
Proteomes	UP000005640
Bgee	P11362
CleanEx	HS_FGFR1 HS_FLG
ExpressionAtlas	P11362
Genevestigator	P11362
GO	GO:0016023 GO:0005829 GO:0005576 GO:0016021 GO:0005887 GO:0005634 GO:0005886 GO:0043235 GO:0005524 GO:0017134 GO:0005007 GO:0008201 GO:0042802 GO:0042803 GO:0004713 GO:0001525 GO:0060117 GO:0007411 GO:0060445 GO:0048469 GO:0016477 GO:0002062 GO:0043009 GO:0030326 GO:0007173 GO:0038095 GO:0008543 GO:0035607 GO:0001701 GO:0045087 GO:0042472 GO:0008286 GO:0060484 GO:0000165 GO:0048762 GO:0030901 GO:0042474 GO:0000122 GO:0001764 GO:0048011 GO:0001759 GO:0042473 GO:0048339 GO:0018108 GO:0048015 GO:0060045 GO:0045787 GO:0008284 GO:0043406 GO:0043410 GO:0090080 GO:0002053 GO:0045666 GO:0010976 GO:0014068 GO:0010518 GO:0010863 GO:0046777 GO:0006468 GO:0060665 GO:0045595 GO:2001239 GO:0048378 GO:0007605 GO:0001501 GO:0048705 GO:0006351 GO:0001657 GO:0021847
Gene3D	2.60.40.10
InterPro	IPR028174 IPR016248 IPR007110 IPR013783 IPR013098 IPR003598 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635
PANTHER	PTHR24416:SF131
Pfam	PF07679 PF07714
PIRSF	PIRSF000628
PRINTS	PR00109
SMART	SM00408 SM00219
SUPFAM	SSF56112
PROSITE	PS50835 PS00107 PS50011 PS00109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	PMID:19229075^[1]	ECO:0000315			P		Figure 1C: an FGFR1 inhibitor (PD173074) suppresses expression of LXRα and apoE mRNA, suggesting that FGFR1 plays a role in the expression of LXRα and apoE Figure 7A: this shows that effect of FGF-1 expression was abolished by inhibition of FGFR1 using inhibitor PD173074	complete
	GO:0043751	polyphosphate:AMP phosphotransferase activity	PMID:0022920^[2]	ECO:0000314			F		Figure 6	complete CACAO 6094
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:23263626^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00000F0F49_9606,RNAcentral:URS00000F6E49_9606,UniProtKB:P09038	P	results_in_movement_of:(CL:1001568)	Seeded From UniProt	complete
involved_in	GO:1905564	positive regulation of vascular endothelial cell proliferation	PMID:23263626^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09038	P	results_in_division_of:(CL:1001568)	Seeded From UniProt	complete
enables	GO:0090722	receptor-receptor interaction	PMID:24157794^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(CHEBI:73364) has_input:(UniProtKB:P08908)	Seeded From UniProt	complete
involved_in	GO:2000546	positive regulation of endothelial cell chemotaxis to fibroblast growth factor	PMID:21885851^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_movement_of:(CL:0002543)	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:8622701^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:8622701^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:8622701^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:8622701^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:18480409^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:20133753^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11362	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:8622701^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:18480409^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:8663044^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:18480409^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:1652059^[10]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:1846977^[11]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:2159626^[12]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010863	positive regulation of phospholipase C activity	PMID:18480409^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8622701^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:18480409^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:1846977^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:2159626^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18480409^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:1652059^[10]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:18480409^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:20133753^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:8622701^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 PANTHER:PTN000699302 RGD:620713 UniProtKB:P11362	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95523 PANTHER:PTN000699279 RGD:2611 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 ZFIN:ZDB-GENE-030323-1	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 PANTHER:PTN001230353 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 PANTHER:PTN001562203 RGD:620713 UniProtKB:P11362 ZFIN:ZDB-GENE-980526-255	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95524 PANTHER:PTN000699279 RGD:2611 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:10830168^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P61148	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12304	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P11487	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P10767	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09038	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08620	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05230	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12304	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P11487	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P10767	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09038	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08620	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05230	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20133753^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11362	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19696444^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11362	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:2000830	positive regulation of parathyroid hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:1903465	positive regulation of mitotic cell cycle DNA replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0090272	negative regulation of fibroblast growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0070640	vitamin D3 metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0060484	lung-associated mesenchyme development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0060445	branching involved in salivary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0060117	auditory receptor cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0051174	regulation of phosphorus metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0048762	mesenchymal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0048699	generation of neurons	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0048469	cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0048378	regulation of lateral mesodermal cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0048339	paraxial mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0043583	ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0042474	middle ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0042473	outer ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	F		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0035607	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0021847	ventricular zone neuroblast division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0021769	orbitofrontal cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	F		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0010966	regulation of phosphate transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0007435	salivary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	C		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	F		Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0001759	organ induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16092 ensembl:ENSMUSP00000081041	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248 InterPro:IPR028174	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR016248 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR016248 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:22235191^[17] PMID:10748122^[18] Reactome:R-HSA-5654736 Reactome:R-HSA-190374 Reactome:R-HSA-190373 Reactome:R-HSA-190370	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000601)	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10918587^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:10748122^[18] PMID:2167437^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	PMID:7874169^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:10748122^[18] Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048705	skeletal system morphogenesis	PMID:15863030^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	PMID:12141425^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	PMID:12141425^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043009	chordate embryonic development	PMID:15863030^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:15863030^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:15863030^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010518	positive regulation of phospholipase activity	PMID:12141425^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:15863030^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8853325 Reactome:R-HSA-8853322 Reactome:R-HSA-5672965 Reactome:R-HSA-5656064 Reactome:R-HSA-5655326 Reactome:R-HSA-5655290 Reactome:R-HSA-5655278 Reactome:R-HSA-5655269 Reactome:R-HSA-5655266 Reactome:R-HSA-5655263 Reactome:R-HSA-5655240 Reactome:R-HSA-5654692 Reactome:R-HSA-5654690 Reactome:R-HSA-5654673 Reactome:R-HSA-5654672 Reactome:R-HSA-5654600 Reactome:R-HSA-5654597 Reactome:R-HSA-5654596 Reactome:R-HSA-5654594 Reactome:R-HSA-5654592 Reactome:R-HSA-5654591 Reactome:R-HSA-5654587 Reactome:R-HSA-5654586 Reactome:R-HSA-5654584 Reactome:R-HSA-5654582 Reactome:R-HSA-5654578 Reactome:R-HSA-5654575 Reactome:R-HSA-5654573 Reactome:R-HSA-5654571 Reactome:R-HSA-5654569 Reactome:R-HSA-5654560 Reactome:R-HSA-5654545 Reactome:R-HSA-5654544 Reactome:R-HSA-5654514 Reactome:R-HSA-5654392 Reactome:R-HSA-5654167 Reactome:R-HSA-5654165 Reactome:R-HSA-5654149 Reactome:R-HSA-437230 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434 Reactome:R-HSA-2023462 Reactome:R-HSA-2023460 Reactome:R-HSA-2023456 Reactome:R-HSA-2023455 Reactome:R-HSA-2023451 Reactome:R-HSA-1982066 Reactome:R-HSA-1982065 Reactome:R-HSA-191062 Reactome:R-HSA-190429 Reactome:R-HSA-190427 Reactome:R-HSA-190268 Reactome:R-HSA-190256 Reactome:R-HSA-190245 Reactome:R-HSA-1839100 Reactome:R-HSA-1839098 Reactome:R-HSA-1839094 Reactome:R-HSA-109699	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lu, R et al. (2009) FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J. Lipid Res. 50 1156-64 PubMed GONUTS page
↑ Geavlete, A et al. () [Diagnostic criteria and some initial forms of disseminated lupus erythematosus (DLE)]. Rev Med Interna Neurol Psihiatr Neurochir Dermatovenerol Med Interna 29 371-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Kim, J et al. (2013) An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nat. Med. 19 74-82 PubMed GONUTS page
↑ Borroto-Escuela, DO et al. (2013) Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2. Biochem. Biophys. Res. Commun. 441 387-92 PubMed GONUTS page
↑ Chamorro-Jorganes, A et al. (2011) MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler. Thromb. Vasc. Biol. 31 2595-606 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Mohammadi, M et al. (1996) Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol. Cell. Biol. 16 977-89 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Haugsten, EM et al. (2008) Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis. Mol. Biol. Cell 19 3390-403 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Bae, JH et al. (2010) Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells. Proc. Natl. Acad. Sci. U.S.A. 107 2866-71 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 ^9.14 Ornitz, DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271 15292-7 PubMed GONUTS page
↑ ^10.0 ^10.1 Johnson, DE et al. (1991) The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain. Mol. Cell. Biol. 11 4627-34 PubMed GONUTS page
↑ ^11.0 ^11.1 Hou, JZ et al. (1991) Fibroblast growth factor receptors from liver vary in three structural domains. Science 251 665-8 PubMed GONUTS page
↑ ^12.0 ^12.1 Isacchi, A et al. (1990) Complete sequence of a human receptor for acidic and basic fibroblast growth factors. Nucleic Acids Res. 18 1906 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ Plotnikov, AN et al. (2000) Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell 101 413-24 PubMed GONUTS page
↑ Hu, Y et al. (2009) Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1. J. Biol. Chem. 284 29905-20 PubMed GONUTS page
↑ Huh, SH et al. (2012) Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS Biol. 10 e1001231 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Lopez, ME & Korc, M (2000) A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2. J. Biol. Chem. 275 15933-9 PubMed GONUTS page
↑ Hart, KC et al. (2000) Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene 19 3309-20 PubMed GONUTS page
↑ Johnson, DE et al. (1990) Diverse forms of a receptor for acidic and basic fibroblast growth factors. Mol. Cell. Biol. 10 4728-36 PubMed GONUTS page
↑ Muenke, M et al. (1994) A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. Nat. Genet. 8 269-74 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 Eswarakumar, VP et al. (2005) Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 16 139-49 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Groth, C & Lardelli, M (2002) The structure and function of vertebrate fibroblast growth factor receptor 1. Int. J. Dev. Biol. 46 393-400 PubMed GONUTS page

[PMID:19229075-1] Lu, R et al. (2009) FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J. Lipid Res. 50 1156-64 PubMed GONUTS page

[PMID:0022920-2] Geavlete, A et al. () [Diagnostic criteria and some initial forms of disseminated lupus erythematosus (DLE)]. Rev Med Interna Neurol Psihiatr Neurochir Dermatovenerol Med Interna 29 371-8 PubMed GONUTS page

[PMID:23263626-3] 3.0 ^3.1 Kim, J et al. (2013) An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nat. Med. 19 74-82 PubMed GONUTS page

[PMID:24157794-4] Borroto-Escuela, DO et al. (2013) Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2. Biochem. Biophys. Res. Commun. 441 387-92 PubMed GONUTS page

[PMID:21885851-5] Chamorro-Jorganes, A et al. (2011) MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler. Thromb. Vasc. Biol. 31 2595-606 PubMed GONUTS page

[PMID:8622701-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Mohammadi, M et al. (1996) Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol. Cell. Biol. 16 977-89 PubMed GONUTS page

[PMID:18480409-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Haugsten, EM et al. (2008) Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis. Mol. Biol. Cell 19 3390-403 PubMed GONUTS page

[PMID:20133753-8] 8.0 ^8.1 ^8.2 Bae, JH et al. (2010) Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells. Proc. Natl. Acad. Sci. U.S.A. 107 2866-71 PubMed GONUTS page

[PMID:8663044-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 ^9.14 Ornitz, DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271 15292-7 PubMed GONUTS page

[PMID:1652059-10] 10.0 ^10.1 Johnson, DE et al. (1991) The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain. Mol. Cell. Biol. 11 4627-34 PubMed GONUTS page

[PMID:1846977-11] 11.0 ^11.1 Hou, JZ et al. (1991) Fibroblast growth factor receptors from liver vary in three structural domains. Science 251 665-8 PubMed GONUTS page

[PMID:2159626-12] 12.0 ^12.1 Isacchi, A et al. (1990) Complete sequence of a human receptor for acidic and basic fibroblast growth factors. Nucleic Acids Res. 18 1906 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23382219-14] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

[PMID:10830168-15] Plotnikov, AN et al. (2000) Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell 101 413-24 PubMed GONUTS page

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[PMID:22235191-17] Huh, SH et al. (2012) Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS Biol. 10 e1001231 PubMed GONUTS page

[PMID:10748122-18] 18.0 ^18.1 ^18.2 Lopez, ME & Korc, M (2000) A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2. J. Biol. Chem. 275 15933-9 PubMed GONUTS page

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[PMID:7874169-21] Muenke, M et al. (1994) A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. Nat. Genet. 8 269-74 PubMed GONUTS page

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HUMAN:FGFR1

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