HUMAN:FGF1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FGF1 (synonyms: FGFA)
Protein Name(s)	Fibroblast growth factor 1 FGF-1 Acidic fibroblast growth factor aFGF Endothelial cell growth factor ECGF Heparin-binding growth factor 1 HBGF-1
External Links
UniProt	P05230
EMBL	M13361 M30492 M30490 M30491 M23087 M23086 X51943 X65778 S67291 S67292 AY601819 AC005370 AK312301 CH471062 CH471062 CH471062 BC032697 M60515 M60516
CCDS	CCDS4275.1 CCDS4276.1
PIR	A33665 JH0708
RefSeq	NP_000791.1 NP_001138364.1 NP_001138406.1 NP_001138407.1 NP_001244134.1 NP_001244136.1 NP_001244137.1 NP_001244138.1 NP_001244139.1 NP_149127.1 NP_149128.1
UniGene	Hs.483635
PDB	1AXM 1DJS 1DZC 1DZD 1E0O 1EVT 1HKN 1JQZ 1JT3 1JT4 1JT5 1JT7 1JTC 1JY0 1K5U 1K5V 1M16 1NZK 1P63 1PZZ 1Q03 1Q04 1QCT 1RG8 1RML 1RY7 1YTO 1Z2V 1Z4S 2AFG 2AQZ 2AXM 2ERM 2HW9 2HWA 2HWM 2HZ9 2K43 2K4A 2K8R 2KI4 2KI6 2LDN 2NTD 2Q9X 2RQ9 3B9U 3BA4 3BA5 3BA7 3BAD 3BAG 3BAH 3BAO 3BAQ 3BAU 3BAV 3BB2 3CQA 3CRG 3CRH 3CRI 3CU1 3FGM 3FJ8 3FJ9 3FJA 3FJB 3FJC 3FJD 3FJE 3FJF 3FJH 3FJI 3FJJ 3FJK 3HOM 3JUT 3K1X 3O3Q 3OJ2 3OJM 3OJV 3UD7 3UD8 3UD9 3UDA 4J23
PDBsum	1AXM 1DJS 1DZC 1DZD 1E0O 1EVT 1HKN 1JQZ 1JT3 1JT4 1JT5 1JT7 1JTC 1JY0 1K5U 1K5V 1M16 1NZK 1P63 1PZZ 1Q03 1Q04 1QCT 1RG8 1RML 1RY7 1YTO 1Z2V 1Z4S 2AFG 2AQZ 2AXM 2ERM 2HW9 2HWA 2HWM 2HZ9 2K43 2K4A 2K8R 2KI4 2KI6 2LDN 2NTD 2Q9X 2RQ9 3B9U 3BA4 3BA5 3BA7 3BAD 3BAG 3BAH 3BAO 3BAQ 3BAU 3BAV 3BB2 3CQA 3CRG 3CRH 3CRI 3CU1 3FGM 3FJ8 3FJ9 3FJA 3FJB 3FJC 3FJD 3FJE 3FJF 3FJH 3FJI 3FJJ 3FJK 3HOM 3JUT 3K1X 3O3Q 3OJ2 3OJM 3OJV 3UD7 3UD8 3UD9 3UDA 4J23
ProteinModelPortal	P05230
SMR	P05230
BioGrid	108537
DIP	DIP-3787N
IntAct	P05230
MINT	MINT-118570
STRING	9606.ENSP00000338548
BindingDB	P05230
ChEMBL	CHEMBL2120
DrugBank	DB01025 DB06589 DB00686
DMDM	122737
MaxQB	P05230
PaxDb	P05230
PRIDE	P05230
DNASU	2246
Ensembl	ENST00000337706 ENST00000359370 ENST00000360966 ENST00000378046 ENST00000419524 ENST00000441680 ENST00000610990 ENST00000612258 ENST00000619447 ENST00000621536
GeneID	2246
KEGG	hsa:2246
UCSC	uc003lmm.4 uc003lmp.5
CTD	2246
GeneCards	GC05M141953
HGNC	HGNC:3665
HPA	CAB017519 HPA003265
MIM	131220
neXtProt	NX_P05230
PharmGKB	PA28105
eggNOG	NOG246422
GeneTree	ENSGT00730000110923
HOGENOM	HOG000236341
HOVERGEN	HBG007580
InParanoid	P05230
KO	K18496
OMA	LGPRTHY
OrthoDB	EOG7992S1
PhylomeDB	P05230
TreeFam	TF317805
Reactome	REACT_111184 REACT_120863 REACT_121153 REACT_121249 REACT_121337 REACT_121398 REACT_147727 REACT_21247 REACT_21270 REACT_21310 REACT_21374 REACT_75829 REACT_9400 REACT_9413 REACT_9416 REACT_9452 REACT_9508 REACT_9510 REACT_9515 REACT_976
SignaLink	P05230
ChiTaRS	FGF1
EvolutionaryTrace	P05230
GeneWiki	FGF1
GenomeRNAi	2246
NextBio	9087
PRO	PR:P05230
Proteomes	UP000005640
Bgee	P05230
CleanEx	HS_FGF1
ExpressionAtlas	P05230
Genevestigator	P05230
GO	GO:0005938 GO:0005829 GO:0005576 GO:0005615 GO:0005634 GO:0005104 GO:0008083 GO:0008201 GO:0044548 GO:0009653 GO:0001525 GO:0060681 GO:0030154 GO:0034605 GO:0007173 GO:0038095 GO:0008543 GO:0045087 GO:0008286 GO:0072163 GO:0007275 GO:0048011 GO:0048015 GO:0045766 GO:0051781 GO:0030335 GO:0008284 GO:0045542 GO:1902533 GO:0045944 GO:0007165
InterPro	IPR008996 IPR028210 IPR002209 IPR028142
PANTHER	PTHR11486 PTHR11486:SF65
PRINTS	PR00263 PR00262
SMART	SM00442
SUPFAM	SSF50353
PROSITE	PS00247

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	PMID:19229075^[1]	ECO:0000314			P		Figure 1A: FGF-1 increases the expression of LXRα mRNA Figure 1A: FGF-1 increases the expression of apoE mRNA Figure 1B: FGF-1 increases the expression of ABCA1 mRNA Figure 4B: the luciferase assay shows that FGF-1 activates the apoE gene. Also figure 4C shows that responses of the reporter gene to FGF-1 disappear when a mutation is introduced on the promoter sequence Figure 5: Chip assay demonstrated that FGF-1 activates LXR to enhance expression of the apoE gene through its interaction with the LXRE of the endogenous apoE promoter NOTE: From the company's website the only recombinant FGF-1 protein they have at the moment is human, so I’m assuming it is human based on the current Sigma-Aldrich catalogue.	complete
	GO:0045542	positive regulation of cholesterol biosynthetic process	PMID:19229075^[1]	ECO:0000314			P		Figure 6A: this shows that cholesterol biosynthesis is increased by FGF-1 Figure 6D: this shows an increase of cholesterol 25-hydroxylase mRNA by FGF-1 Figure 6F: this shows an increase of 25-hydroxycholesterol (a ligand of LXR) by FGF-1 Figure 6B: this shows that IGF-1 increases the expression of HMG-CoA reductase gene NOTE 1: From the company's website the only recombinant FGF-1 protein they have at the moment is human, so I’m assuming it is human based on the current Sigma-Aldrich catalogue. NOTE 2: a more specific term could be used if it was available "regulation of cellular cholesterol metabolic process by positive regulation of transcription from an RNA polymerase II promoter"	complete
	GO:0009306	protein secretion	PMID:19229075^[1]	ECO:0000314			P		Figure 2 and 3: The presence of FGF-1 resulted in an increase in the levels of secreted apoE protein NOTE 1: From the company's website the only recombinant FGF-1 protein they have at the moment is human, so I’m assuming it is human based on the current Sigma-Aldrich catalogue. NOTE 2: a more specific term could be used if it was available “apolipoprotein secretion”	complete
enables	GO:0005104	fibroblast growth factor receptor binding	PMID:18441324^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:18441324^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	PMID:18441324^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:18441324^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:18441324^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:18441324^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:18441324^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:18441324^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1901509	regulation of endothelial tube morphogenesis	PMID:23469107^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:23469107^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:23469107^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	PMID:23469107^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:16756958^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:2000544	regulation of endothelial cell chemotaxis to fibroblast growth factor	PMID:16756958^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0009611) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:3778488^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902533	positive regulation of intracellular signal transduction	PMID:19229075^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19229075^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045542	positive regulation of cholesterol biosynthetic process	PMID:19229075^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072163	mesonephric epithelium development	PMID:11731227^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060681	branch elongation involved in ureteric bud branching	PMID:11731227^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	PMID:20145243^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:20145243^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044548	S100 protein binding	PMID:11432880^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99584	F		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:12746488^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:20145243^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:20145243^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:20145243^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:20145243^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12746488^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18400376^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:12746488^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:10830168^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11362	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P22607	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P21802	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P11362	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:18187602^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61851	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:18187602^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q03142	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:18187602^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:18187602^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P16092	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P21802	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P11362	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:18187602^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61851	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:18187602^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q03142	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:18187602^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:18187602^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P16092	P		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	PMID:12815063^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22607-2	F		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	PMID:12815063^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22607-1	F		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	PMID:10830168^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11362	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61148 ensembl:ENSMUSP00000045710	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61148 ensembl:ENSMUSP00000045710	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61148 ensembl:ENSMUSP00000045710	C		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61148 ensembl:ENSMUSP00000045710	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61148 ensembl:ENSMUSP00000045710	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61148 ensembl:ENSMUSP00000045710	C		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61148 ensembl:ENSMUSP00000045710	P		Seeded From UniProt	complete
involved_in	GO:0001759	organ induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61148 ensembl:ENSMUSP00000045710	P		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61149 ensembl:ENSRNOP00000070685	F		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61149 ensembl:ENSRNOP00000070685	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61149 ensembl:ENSRNOP00000070685	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61149 ensembl:ENSRNOP00000070685	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61149 ensembl:ENSRNOP00000070685	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61149 ensembl:ENSRNOP00000070685	C		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028210	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028210	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002209	F		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028210	P		Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:1693186^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:1693186^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:10903182^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:R-HSA-5654743 Reactome:R-HSA-5654741 Reactome:R-HSA-5654738 Reactome:R-HSA-5654736 Reactome:R-HSA-190377 Reactome:R-HSA-190375 Reactome:R-HSA-190373 Reactome:R-HSA-190372 Reactome:R-HSA-190371 Reactome:R-HSA-190370 Reactome:R-HSA-190322	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-8853328 Reactome:R-HSA-5672965 Reactome:R-HSA-5656064 Reactome:R-HSA-5655343 Reactome:R-HSA-5655339 Reactome:R-HSA-5655326 Reactome:R-HSA-5655323 Reactome:R-HSA-5655320 Reactome:R-HSA-5655315 Reactome:R-HSA-5655301 Reactome:R-HSA-5655295 Reactome:R-HSA-5655290 Reactome:R-HSA-5655289 Reactome:R-HSA-5655285 Reactome:R-HSA-5655278 Reactome:R-HSA-5655277 Reactome:R-HSA-5655270 Reactome:R-HSA-5655269 Reactome:R-HSA-5655268 Reactome:R-HSA-5655266 Reactome:R-HSA-5655263 Reactome:R-HSA-5655262 Reactome:R-HSA-5655247 Reactome:R-HSA-5655245 Reactome:R-HSA-5655244 Reactome:R-HSA-5655243 Reactome:R-HSA-5655241 Reactome:R-HSA-5655240 Reactome:R-HSA-5655233 Reactome:R-HSA-5654748 Reactome:R-HSA-5654734 Reactome:R-HSA-5654730 Reactome:R-HSA-5654729 Reactome:R-HSA-5654717 Reactome:R-HSA-5654714 Reactome:R-HSA-5654709 Reactome:R-HSA-5654705 Reactome:R-HSA-5654701 Reactome:R-HSA-5654697 Reactome:R-HSA-5654692 Reactome:R-HSA-5654690 Reactome:R-HSA-5654159 Reactome:R-HSA-5654157 Reactome:R-HSA-5654151 Reactome:R-HSA-5654149 Reactome:R-HSA-5654148 Reactome:R-HSA-5654147 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434 Reactome:R-HSA-2077424 Reactome:R-HSA-2077421 Reactome:R-HSA-2077420 Reactome:R-HSA-2033488 Reactome:R-HSA-2033486 Reactome:R-HSA-2033474 Reactome:R-HSA-2033472 Reactome:R-HSA-2023455 Reactome:R-HSA-2023451 Reactome:R-HSA-2012074 Reactome:R-HSA-2012073 Reactome:R-HSA-190429 Reactome:R-HSA-190427 Reactome:R-HSA-190413 Reactome:R-HSA-190408 Reactome:R-HSA-190388 Reactome:R-HSA-190385 Reactome:R-HSA-190326 Reactome:R-HSA-190265 Reactome:R-HSA-190263 Reactome:R-HSA-190261 Reactome:R-HSA-190260 Reactome:R-HSA-190258 Reactome:R-HSA-190256 Reactome:R-HSA-190245 Reactome:R-HSA-1839100 Reactome:R-HSA-1839098 Reactome:R-HSA-1839094 Reactome:R-HSA-109699 Reactome:R-HSA-5654684 Reactome:R-HSA-5654679 Reactome:R-HSA-5654677 Reactome:R-HSA-5654673 Reactome:R-HSA-5654672 Reactome:R-HSA-5654669 Reactome:R-HSA-5654667 Reactome:R-HSA-5654664 Reactome:R-HSA-5654663 Reactome:R-HSA-5654662 Reactome:R-HSA-5654659 Reactome:R-HSA-5654658 Reactome:R-HSA-5654655 Reactome:R-HSA-5654653 Reactome:R-HSA-5654651 Reactome:R-HSA-5654647 Reactome:R-HSA-5654646 Reactome:R-HSA-5654643 Reactome:R-HSA-5654641 Reactome:R-HSA-5654640 Reactome:R-HSA-5654637 Reactome:R-HSA-5654634 Reactome:R-HSA-5654633 Reactome:R-HSA-5654631 Reactome:R-HSA-5654628 Reactome:R-HSA-5654625 Reactome:R-HSA-5654623 Reactome:R-HSA-5654622 Reactome:R-HSA-5654620 Reactome:R-HSA-5654618 Reactome:R-HSA-5654615 Reactome:R-HSA-5654614 Reactome:R-HSA-5654612 Reactome:R-HSA-5654608 Reactome:R-HSA-5654607 Reactome:R-HSA-5654605 Reactome:R-HSA-5654603 Reactome:R-HSA-5654600 Reactome:R-HSA-5654597 Reactome:R-HSA-5654596 Reactome:R-HSA-5654594 Reactome:R-HSA-5654592 Reactome:R-HSA-5654591 Reactome:R-HSA-5654587 Reactome:R-HSA-5654586 Reactome:R-HSA-5654584 Reactome:R-HSA-5654582 Reactome:R-HSA-5654578 Reactome:R-HSA-5654575 Reactome:R-HSA-5654573 Reactome:R-HSA-5654571 Reactome:R-HSA-5654569 Reactome:R-HSA-5654566 Reactome:R-HSA-5654565 Reactome:R-HSA-5654562 Reactome:R-HSA-5654560 Reactome:R-HSA-5654428 Reactome:R-HSA-5654426 Reactome:R-HSA-5654425 Reactome:R-HSA-5654423 Reactome:R-HSA-5654422 Reactome:R-HSA-5654418 Reactome:R-HSA-5654416 Reactome:R-HSA-5654413 Reactome:R-HSA-5654409 Reactome:R-HSA-5654408 Reactome:R-HSA-5654407 Reactome:R-HSA-5654406 Reactome:R-HSA-5654404 Reactome:R-HSA-5654402 Reactome:R-HSA-5654399 Reactome:R-HSA-5654397 Reactome:R-HSA-5654392 Reactome:R-HSA-5654224 Reactome:R-HSA-5654222 Reactome:R-HSA-5654169 Reactome:R-HSA-5654167 Reactome:R-HSA-5654165 Reactome:R-HSA-5654163	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Lu, R et al. (2009) FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J. Lipid Res. 50 1156-64 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Mori, S et al. (2008) Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. J. Biol. Chem. 283 18066-75 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Mori, S et al. (2013) A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis. PLoS ONE 8 e57927 PubMed GONUTS page
↑ ^4.0 ^4.1 Antoine, M et al. (2006) Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. Biochem. Biophys. Res. Commun. 346 224-33 PubMed GONUTS page
↑ Gautschi-Sova, P et al. (1986) Amino acid sequence of human acidic fibroblast growth factor. Biochem. Biophys. Res. Commun. 140 874-80 PubMed GONUTS page
↑ ^6.0 ^6.1 Qiao, J et al. (2001) Multiple fibroblast growth factors support growth of the ureteric bud but have different effects on branching morphogenesis. Mech. Dev. 109 123-35 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Fernández, IS et al. (2010) Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. J. Biol. Chem. 285 11714-29 PubMed GONUTS page
↑ Landriscina, M et al. (2001) Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress. J. Biol. Chem. 276 25549-57 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Mandinova, A et al. (2003) S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells. J. Cell. Sci. 116 2687-96 PubMed GONUTS page
↑ Di Serio, C et al. (2008) The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. Cancer Lett. 267 67-74 PubMed GONUTS page
↑ ^11.0 ^11.1 Plotnikov, AN et al. (2000) Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell 101 413-24 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Ornitz, DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271 15292-7 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Suzuki, M et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol. Endocrinol. 22 1006-14 PubMed GONUTS page
↑ ^14.0 ^14.1 Olsen, SK et al. (2003) Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J. Biol. Chem. 278 34226-36 PubMed GONUTS page
↑ ^15.0 ^15.1 Chiu, IM et al. (1990) Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. Oncogene 5 755-62 PubMed GONUTS page
↑ Nguyen, M & Arnheiter, H (2000) Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF. Development 127 3581-91 PubMed GONUTS page

[PMID:19229075-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Lu, R et al. (2009) FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J. Lipid Res. 50 1156-64 PubMed GONUTS page

[PMID:18441324-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Mori, S et al. (2008) Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. J. Biol. Chem. 283 18066-75 PubMed GONUTS page

[PMID:23469107-3] 3.0 ^3.1 ^3.2 ^3.3 Mori, S et al. (2013) A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis. PLoS ONE 8 e57927 PubMed GONUTS page

[PMID:16756958-4] 4.0 ^4.1 Antoine, M et al. (2006) Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. Biochem. Biophys. Res. Commun. 346 224-33 PubMed GONUTS page

[PMID:3778488-5] Gautschi-Sova, P et al. (1986) Amino acid sequence of human acidic fibroblast growth factor. Biochem. Biophys. Res. Commun. 140 874-80 PubMed GONUTS page

[PMID:11731227-6] 6.0 ^6.1 Qiao, J et al. (2001) Multiple fibroblast growth factors support growth of the ureteric bud but have different effects on branching morphogenesis. Mech. Dev. 109 123-35 PubMed GONUTS page

[PMID:20145243-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Fernández, IS et al. (2010) Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. J. Biol. Chem. 285 11714-29 PubMed GONUTS page

[PMID:11432880-8] Landriscina, M et al. (2001) Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress. J. Biol. Chem. 276 25549-57 PubMed GONUTS page

[PMID:12746488-9] 9.0 ^9.1 ^9.2 Mandinova, A et al. (2003) S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells. J. Cell. Sci. 116 2687-96 PubMed GONUTS page

[PMID:18400376-10] Di Serio, C et al. (2008) The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. Cancer Lett. 267 67-74 PubMed GONUTS page

[PMID:10830168-11] 11.0 ^11.1 Plotnikov, AN et al. (2000) Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell 101 413-24 PubMed GONUTS page

[PMID:8663044-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Ornitz, DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271 15292-7 PubMed GONUTS page

[PMID:18187602-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Suzuki, M et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol. Endocrinol. 22 1006-14 PubMed GONUTS page

[PMID:12815063-14] 14.0 ^14.1 Olsen, SK et al. (2003) Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J. Biol. Chem. 278 34226-36 PubMed GONUTS page

[PMID:1693186-15] 15.0 ^15.1 Chiu, IM et al. (1990) Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. Oncogene 5 755-62 PubMed GONUTS page

[PMID:10903182-16] Nguyen, M & Arnheiter, H (2000) Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF. Development 127 3581-91 PubMed GONUTS page

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