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HUMAN:FCN3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | FCN3 (synonyms: FCNH, HAKA1) | |
| Protein Name(s) | Ficolin-3
Collagen/fibrinogen domain-containing lectin 3 p35 Collagen/fibrinogen domain-containing protein 3 Hakata antigen | |
| External Links | ||
| UniProt | O75636 | |
| EMBL | D88587 AK075140 CR456808 AY756173 FO393419 BC020731 | |
| CCDS | CCDS300.1 CCDS301.1 | |
| RefSeq | NP_003656.2 NP_775628.1 | |
| UniGene | Hs.333383 | |
| PDB | 1LA5 2J5Z 2J60 2J64 | |
| PDBsum | 1LA5 2J5Z 2J60 2J64 | |
| ProteinModelPortal | O75636 | |
| SMR | O75636 | |
| BioGrid | 114117 | |
| STRING | 9606.ENSP00000270879 | |
| PaxDb | O75636 | |
| PeptideAtlas | O75636 | |
| PRIDE | O75636 | |
| DNASU | 8547 | |
| Ensembl | ENST00000270879 ENST00000354982 | |
| GeneID | 8547 | |
| KEGG | hsa:8547 | |
| UCSC | uc001boa.3 | |
| CTD | 8547 | |
| GeneCards | GC01M027695 | |
| HGNC | HGNC:3625 | |
| HPA | CAB025945 | |
| MIM | 604973 613860 | |
| neXtProt | NX_O75636 | |
| Orphanet | 331190 | |
| PharmGKB | PA28071 | |
| eggNOG | NOG331678 | |
| GeneTree | ENSGT00770000120463 | |
| HOGENOM | HOG000037127 | |
| HOVERGEN | HBG001644 | |
| InParanoid | O75636 | |
| KO | K10104 | |
| OMA | SSYKAGF | |
| OrthoDB | EOG7X9G60 | |
| PhylomeDB | O75636 | |
| TreeFam | TF351983 | |
| Reactome | REACT_163810 REACT_7964 REACT_8024 | |
| ChiTaRS | FCN3 | |
| EvolutionaryTrace | O75636 | |
| GeneWiki | FCN3 | |
| GenomeRNAi | 8547 | |
| NextBio | 32022 | |
| PRO | PR:O75636 | |
| Proteomes | UP000005640 | |
| Bgee | O75636 | |
| CleanEx | HS_FCN3 | |
| ExpressionAtlas | O75636 | |
| Genevestigator | O75636 | |
| GO | GO:0072562 GO:0005581 GO:0005576 GO:0030246 GO:0006956 GO:0001867 GO:0045087 | |
| Gene3D | 3.90.215.10 4.10.530.10 | |
| InterPro | IPR008160 IPR014716 IPR014715 IPR002181 IPR020837 | |
| Pfam | PF01391 PF00147 | |
| SMART | SM00186 | |
| SUPFAM | SSF56496 | |
| PROSITE | PS00514 PS51406 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0043654 |
recognition of apoptotic cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006956 |
complement activation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003823 |
antigen binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902679 |
negative regulation of RNA biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_input:(UniProtKB:P06821) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046597 |
negative regulation of viral entry into host cell |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0001977) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(UBERON:0001977) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0072562 |
blood microparticle |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001867 |
complement activation, lectin pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030246 |
carbohydrate binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006956 |
complement activation |
Reactome:R-HSA-166663 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-2855077 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0001867 |
complement activation, lectin pathway |
Reactome:R-HSA-2855086 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030246 |
carbohydrate binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001867 |
complement activation, lectin pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005581 |
collagen trimer |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kuraya, M et al. (2005) Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation. Immunobiology 209 689-97 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Verma, A et al. (2012) Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses. J. Immunol. 189 2478-87 PubMed GONUTS page
- ↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
- ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
- ↑ Matsushita, M et al. (2002) Activation of the lectin complement pathway by H-ficolin (Hakata antigen). J. Immunol. 168 3502-6 PubMed GONUTS page
- ↑ Sugimoto, R et al. (1998) Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family. J. Biol. Chem. 273 20721-7 PubMed GONUTS page
