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HUMAN:FABP5
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | FABP5 | |
| Protein Name(s) | Fatty acid-binding protein, epidermal
Epidermal-type fatty acid-binding protein E-FABP Fatty acid-binding protein 5 Psoriasis-associated fatty acid-binding protein homolog PA-FABP | |
| External Links | ||
| UniProt | Q01469 | |
| EMBL | M94856 BT007449 AK311856 CH471068 BC019385 BC070303 | |
| CCDS | CCDS6228.1 | |
| PIR | I56326 | |
| RefSeq | NP_001435.1 | |
| UniGene | Hs.408061 | |
| PDB | 1B56 1JJJ 4AZM 4AZR 4LKP 4LKT | |
| PDBsum | 1B56 1JJJ 4AZM 4AZR 4LKP 4LKT | |
| ProteinModelPortal | Q01469 | |
| SMR | Q01469 | |
| BioGrid | 108469 | |
| IntAct | Q01469 | |
| MINT | MINT-3024261 | |
| STRING | 9606.ENSP00000297258 | |
| BindingDB | Q01469 | |
| ChEMBL | CHEMBL3674 | |
| TCDB | 8.A.33.1.1 | |
| PhosphoSite | Q01469 | |
| DMDM | 232081 | |
| SWISS-2DPAGE | Q01469 | |
| UCD-2DPAGE | Q01469 | |
| MaxQB | Q01469 | |
| PaxDb | Q01469 | |
| PRIDE | Q01469 | |
| DNASU | 2171 | |
| Ensembl | ENST00000297258 | |
| GeneID | 2171 | |
| KEGG | hsa:2171 | |
| UCSC | uc003yca.2 | |
| CTD | 2171 | |
| GeneCards | GC08P082242 | |
| HGNC | HGNC:3560 | |
| HPA | CAB017831 CAB040577 | |
| MIM | 605168 | |
| neXtProt | NX_Q01469 | |
| PharmGKB | PA27961 | |
| eggNOG | NOG309791 | |
| GeneTree | ENSGT00760000118898 | |
| HOGENOM | HOG000004829 | |
| HOVERGEN | HBG005633 | |
| InParanoid | Q01469 | |
| KO | K08754 | |
| OMA | VECDMNG | |
| OrthoDB | EOG7NW6BZ | |
| PhylomeDB | Q01469 | |
| TreeFam | TF316894 | |
| EvolutionaryTrace | Q01469 | |
| GeneWiki | FABP5 | |
| GenomeRNAi | 2171 | |
| NextBio | 8767 | |
| PRO | PR:Q01469 | |
| Proteomes | UP000005640 | |
| Bgee | Q01469 | |
| CleanEx | HS_FABP5 | |
| ExpressionAtlas | Q01469 | |
| Genevestigator | Q01469 | |
| GO | GO:0005737 GO:0070062 GO:0005504 GO:0008289 GO:0005215 GO:0008544 GO:0006006 GO:0015758 GO:0006629 GO:0006656 GO:0009611 | |
| Gene3D | 2.40.128.20 | |
| InterPro | IPR012674 IPR011038 IPR000463 IPR000566 | |
| Pfam | PF00061 | |
| PRINTS | PR00178 | |
| SUPFAM | SSF50814 | |
| PROSITE | PS00214 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000639) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0099178 |
regulation of retrograde trans-synaptic signaling by endocanabinoid |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005504 |
fatty acid binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0099178 |
regulation of retrograde trans-synaptic signaling by endocanabinoid |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051930 |
regulation of sensory perception of pain |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045202 |
synapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042593 |
glucose homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035360 |
positive regulation of peroxisome proliferator activated receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031392 |
regulation of prostaglandin biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010829 |
negative regulation of glucose transmembrane transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006656 |
phosphatidylcholine biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006006 |
glucose metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001972 |
retinoic acid binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q05816 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008544 |
epidermis development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005504 |
fatty acid binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035578 |
azurophil granule lumen |
Reactome:R-HSA-6798751 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030667 |
secretory granule membrane |
Reactome:R-HSA-6798743 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019433 |
triglyceride catabolic process |
Reactome:R-HSA-163560 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-6798743 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-5633256 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-5634100 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6798751 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045211 |
postsynaptic membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Sanson, B et al. (2014) Crystallographic study of FABP5 as an intracellular endocannabinoid transporter. Acta Crystallogr. D Biol. Crystallogr. 70 290-8 PubMed GONUTS page
- ↑ Syamsunarno, MR et al. (2014) Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress. PLoS ONE 9 e90825 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ 4.0 4.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
- ↑ Armstrong, EH et al. (2014) Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway. J. Biol. Chem. 289 14941-54 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Siegenthaler, G et al. (1994) Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro. Biochem. J. 302 ( Pt 2) 363-71 PubMed GONUTS page
- ↑ 7.0 7.1 Madsen, P et al. (1992) Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. J. Invest. Dermatol. 99 299-305 PubMed GONUTS page
- ↑ Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page
c
e
n
p
- GO:0006656 ! phosphatidylcholine biosynthetic process
- GO:0005886 ! plasma membrane
- GO:0035360 ! positive regulation of peroxisome proliferator activated receptor signaling pathway
- GO:0120162 ! positive regulation of cold-induced thermogenesis
- GO:0045211 ! postsynaptic membrane
- GO:0014069 ! postsynaptic density
- Primates
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