HUMAN:FA11

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	F11
Protein Name(s)	Coagulation factor XI FXI Plasma thromboplastin antecedent PTA Coagulation factor XIa heavy chain Coagulation factor XIa light chain
External Links
UniProt	P03951
EMBL	M13142 M20218 M18296 M21184 M18298 M18299 M18300 M18301 M18302 M18303 M18304 M19417 M20217 AF045649 AY191837 AC110771 CH471056 BC119014 BC122863
CCDS	CCDS3847.1
PIR	A27431
RefSeq	NP_000119.1
UniGene	Hs.1430
PDB	1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2F83 2FDA 2J8J 2J8L 3BG8 3SOR 3SOS 4NA7 4NA8
PDBsum	1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2F83 2FDA 2J8J 2J8L 3BG8 3SOR 3SOS 4NA7 4NA8
ProteinModelPortal	P03951
SMR	P03951
BioGrid	108458
DIP	DIP-29085N
IntAct	P03951
STRING	9606.ENSP00000264691
BindingDB	P03951
ChEMBL	CHEMBL2820
DrugBank	DB00100
GuidetoPHARMACOLOGY	2360
MEROPS	S01.213
PhosphoSite	P03951
DMDM	119762
PaxDb	P03951
PeptideAtlas	P03951
PRIDE	P03951
Ensembl	ENST00000264692 ENST00000403665
GeneID	2160
KEGG	hsa:2160
UCSC	uc003iza.1
CTD	2160
GeneCards	GC04P187187
HGNC	HGNC:3529
MIM	264900 612416
neXtProt	NX_P03951
Orphanet	329
PharmGKB	PA27941
eggNOG	COG5640
GeneTree	ENSGT00760000118962
HOGENOM	HOG000112467
HOVERGEN	HBG000399
InParanoid	P03951
KO	K01323
OMA	VWHLVGI
OrthoDB	EOG75B84T
PhylomeDB	P03951
TreeFam	TF343687
Reactome	REACT_326
ChiTaRS	F11
EvolutionaryTrace	P03951
GeneWiki	Factor_XI
GenomeRNAi	2160
NextBio	8727
PMAP-CutDB	P03951
PRO	PR:P03951
Proteomes	UP000005640
Bgee	P03951
CleanEx	HS_F11
ExpressionAtlas	P03951
Genevestigator	P03951
GO	GO:0005576 GO:0005615 GO:0070062 GO:0016020 GO:0005886 GO:0008201 GO:0070009 GO:0004252 GO:0007596 GO:0007597 GO:0031639 GO:0051919
InterPro	IPR000177 IPR003014 IPR003609 IPR001254 IPR018114 IPR001314 IPR009003
Pfam	PF00024 PF00089
PRINTS	PR00005 PR00722
SMART	SM00223 SM00020
SUPFAM	SSF50494
PROSITE	PS00495 PS50948 PS50240 PS00134 PS00135

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0007596	blood coagulation	PMID:9169594^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0051919	positive regulation of fibrinolysis	PMID:89876^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031639	plasminogen activation	PMID:89876^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0050818	regulation of coagulation	PMID:25379760^[4]	ECO:0000316		UniProtKB:P03951	P		Figure 2 Effect of miRNAs on FXI expression	complete CACAO 10392
part_of	GO:0005615	extracellular space	PMID:89876^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:9593722^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	PMID:9593722^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:9593722^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	PMID:9593722^[5]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030193	regulation of blood coagulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91Y47 ensembl:ENSMUSP00000034064	P		Seeded From UniProt	complete
enables	GO:0070009	serine-type aminopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K4I9 ensembl:ENSRNOP00000073061	F		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K4I9 ensembl:ENSRNOP00000073061	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K4I9 ensembl:ENSRNOP00000073061	C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001254 InterPro:IPR001314 InterPro:IPR018114	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000177	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000177 InterPro:IPR001254 InterPro:IPR001314 InterPro:IPR018114	P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR035696	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17884987^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03951-1	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16699514^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03951-1	F		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	PMID:10823824^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	PMID:10823824^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007597	blood coagulation, intrinsic pathway	Reactome:R-HSA-140837	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-158419 Reactome:R-HSA-158333 Reactome:R-HSA-158300 Reactome:R-HSA-158145	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-158145	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0720	F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0094	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
involved_in	GO:0007599	hemostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0356	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wojcik, EG et al. (1997) Modification of the N-terminus of human factor IX by defective propeptide cleavage or acetylation results in a destabilized calcium-induced conformation: effects on phospholipid binding and activation by factor XIa. Biochem. J. 323 ( Pt 3) 629-36 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Mandle, RJ Jr & Kaplan, AP (1979) Hageman-factor-dependent fibrinolysis: generation of fibrinolytic activity by the interaction of human activated factor XI and plasminogen. Blood 54 850-62 PubMed GONUTS page
↑ Salloum-Asfar, S et al. (2014) Regulation of coagulation factor XI expression by microRNAs in the human liver. PLoS ONE 9 e111713 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Hsu, TC et al. (1998) Molecular cloning of platelet factor XI, an alternative splicing product of the plasma factor XI gene. J. Biol. Chem. 273 13787-93 PubMed GONUTS page
↑ Samuel, D et al. (2007) Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation. Proc. Natl. Acad. Sci. U.S.A. 104 15693-8 PubMed GONUTS page
↑ Papagrigoriou, E et al. (2006) Crystal structure of the factor XI zymogen reveals a pathway for transactivation. Nat. Struct. Mol. Biol. 13 557-8 PubMed GONUTS page
↑ ^8.0 ^8.1 Ho, DH et al. (2000) The role of high molecular weight kininogen and prothrombin as cofactors in the binding of factor XI A3 domain to the platelet surface. J. Biol. Chem. 275 25139-45 PubMed GONUTS page

[PMID:9169594-1] Wojcik, EG et al. (1997) Modification of the N-terminus of human factor IX by defective propeptide cleavage or acetylation results in a destabilized calcium-induced conformation: effects on phospholipid binding and activation by factor XIa. Biochem. J. 323 ( Pt 3) 629-36 PubMed GONUTS page

[PMID:19056867-2] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:89876-3] 3.0 ^3.1 ^3.2 Mandle, RJ Jr & Kaplan, AP (1979) Hageman-factor-dependent fibrinolysis: generation of fibrinolytic activity by the interaction of human activated factor XI and plasminogen. Blood 54 850-62 PubMed GONUTS page

[PMID:25379760-4] Salloum-Asfar, S et al. (2014) Regulation of coagulation factor XI expression by microRNAs in the human liver. PLoS ONE 9 e111713 PubMed GONUTS page

[PMID:9593722-5] 5.0 ^5.1 ^5.2 ^5.3 Hsu, TC et al. (1998) Molecular cloning of platelet factor XI, an alternative splicing product of the plasma factor XI gene. J. Biol. Chem. 273 13787-93 PubMed GONUTS page

[PMID:17884987-6] Samuel, D et al. (2007) Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation. Proc. Natl. Acad. Sci. U.S.A. 104 15693-8 PubMed GONUTS page

[PMID:16699514-7] Papagrigoriou, E et al. (2006) Crystal structure of the factor XI zymogen reveals a pathway for transactivation. Nat. Struct. Mol. Biol. 13 557-8 PubMed GONUTS page

[PMID:10823824-8] 8.0 ^8.1 Ho, DH et al. (2000) The role of high molecular weight kininogen and prothrombin as cofactors in the binding of factor XI A3 domain to the platelet surface. J. Biol. Chem. 275 25139-45 PubMed GONUTS page

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HUMAN:FA11

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