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HUMAN:F5H1A7
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | RDX | |
Protein Name(s) | Radixin | |
External Links | ||
UniProt | F5H1A7 | |
EMBL | AP000901 AP002788 | |
IPI | IPI01009289 | |
RefSeq | NP_001247423.1 | |
UniGene | Hs.263671 Hs.584560 Hs.741211 | |
ProteinModelPortal | F5H1A7 | |
SMR | F5H1A7 | |
PRIDE | F5H1A7 | |
Ensembl | ENST00000544551 | |
GeneID | 5962 | |
KEGG | hsa:5962 | |
UCSC | uc010rwe.2 | |
CTD | 5962 | |
HGNC | HGNC:9944 | |
KO | K05762 | |
ChiTaRS | RDX | |
GenomeRNAi | 5962 | |
NextBio | 23212 | |
ArrayExpress | F5H1A7 | |
Bgee | F5H1A7 | |
GO | GO:0005737 GO:0005856 GO:0019898 GO:0005886 | |
Gene3D | 1.20.80.10 2.30.29.30 | |
InterPro | IPR011259 IPR000798 IPR014352 IPR019748 IPR019747 IPR000299 IPR018980 IPR008954 IPR011993 | |
Pfam | PF00769 PF09380 PF00373 | |
PRINTS | PR00661 | |
SUPFAM | SSF47031 SSF48678 | |
PROSITE | PS00661 PS50057 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0016477 |
cell migration |
ECO:0000315 |
P |
Figure 1 suggests that depleting radixin decreases cell migration and increases cell area. |
complete | |||||
GO:0005912 |
adherens junction |
ECO:0000315 |
C |
Figure 3 shows that depletion of radixin increases adherens junctions which suggests that radixin has a role in this process. |
complete | |||||
part_of |
GO:0005902 |
microvillus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0045296 |
cadherin binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072659 |
protein localization to plasma membrane |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:1903392 |
negative regulation of adherens junction organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034111 |
negative regulation of homotypic cell-cell adhesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032231 |
regulation of actin filament bundle assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(GO:0071944) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008360 |
regulation of cell shape |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1900027 |
regulation of ruffle assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045792 |
negative regulation of cell size |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030864 |
cortical actin cytoskeleton |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0030175 |
filopodium |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0002258) |
Seeded From UniProt |
complete | ||
part_of |
GO:0030027 |
lamellipodium |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0002258) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005902 |
microvillus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0002258) |
Seeded From UniProt |
complete | ||
colocalizes_with |
GO:0005886 |
plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0002258) |
Seeded From UniProt |
complete | ||
enables |
GO:0051018 |
protein kinase A binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
occurs_in:(CL:0002258) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1900087 |
positive regulation of G1/S transition of mitotic cell cycle |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0097067 |
cellular response to thyroid hormone stimulus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
occurs_in:(CL:0002258) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045184 |
establishment of protein localization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0032487 |
regulation of Rap protein signal transduction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0010737 |
protein kinase A signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
enables |
GO:0051117 |
ATPase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003779 |
actin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002563) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008361 |
regulation of cell size |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043087 |
regulation of GTPase activity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P63000) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008361 |
regulation of cell size |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034260 |
negative regulation of GTPase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P63000) |
Seeded From UniProt |
complete | ||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:1902966 |
positive regulation of protein localization to early endosome |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P51149) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902115 |
regulation of organelle assembly |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
results_in_maturation_of:(GO:0005770) |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000643 |
positive regulation of early endosome to late endosome transport |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
has_input:(UniProtKB:P00533) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903364 |
positive regulation of cellular protein catabolic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P00533) |
Seeded From UniProt |
complete | ||
part_of |
GO:0071944 |
cell periphery |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005925 |
focal adhesion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000639) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061028 |
establishment of endothelial barrier |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001914) |
Seeded From UniProt |
complete | ||
colocalizes_with |
GO:0005925 |
focal adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0051286 |
cell tip |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PT65 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051016 |
barbed-end actin filament capping |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PT65 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045176 |
apical protein localization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PT65 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0036120 |
cellular response to platelet-derived growth factor stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PT65 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032154 |
cleavage furrow |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PT65 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0030496 |
midbody |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PT65 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0030315 |
T-tubule |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PT65 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005913 |
cell-cell adherens junction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PT65 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005902 |
microvillus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PT65 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PT65 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003779 |
actin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E9PT65 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:1900087 |
positive regulation of G1/S transition of mitotic cell cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097067 |
cellular response to thyroid hormone stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045184 |
establishment of protein localization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0045177 |
apical part of cell |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045176 |
apical protein localization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0032420 |
stereocilium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0030864 |
cortical actin cytoskeleton |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0030175 |
filopodium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030033 |
microvillus assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0030027 |
lamellipodium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005902 |
microvillus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0001726 |
ruffle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26043 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003779 |
actin binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008092 |
cytoskeletal protein binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051693 |
actin filament capping |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003779 |
actin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005902 |
microvillus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0032154 |
cleavage furrow |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Valderrama, F et al. (2012) Radixin regulates cell migration and cell-cell adhesion through Rac1. J. Cell. Sci. 125 3310-9 PubMed GONUTS page
- ↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Yang, Q et al. (2007) Ezrin and radixin both regulate the apical membrane localization of ABCC2 (MRP2) in human intestinal epithelial Caco-2 cells. Exp. Cell Res. 313 3517-25 PubMed GONUTS page
- ↑ Kitano, K et al. (2006) Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295-304. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 340-5 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Chirivino, D et al. (2011) The ERM proteins interact with the HOPS complex to regulate the maturation of endosomes. Mol. Biol. Cell 22 375-85 PubMed GONUTS page
- ↑ Fidalgo, M et al. (2012) Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress. J. Biol. Chem. 287 11556-65 PubMed GONUTS page
- ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
- ↑ 12.0 12.1 Aranda, JF et al. (2013) MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression. Mol. Biol. Cell 24 483-94 PubMed GONUTS page
- ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
- ↑ Coene, ED et al. (2011) A novel role for BRCA1 in regulating breast cancer cell spreading and motility. J. Cell Biol. 192 497-512 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
a
c
- GO:0045296 ! cadherin binding
- Catarrhini
- GO:0005913 ! cell-cell adherens junction
- GO:0097067 ! cellular response to thyroid hormone stimulus
- GO:0036120 ! cellular response to platelet-derived growth factor stimulus
- GO:0016477 ! cell migration
- GO:0071944 ! cell periphery
- GO:0042995 ! cell projection
- GO:0051286 ! cell tip
- Chordata
- GO:0032154 ! cleavage furrow
- GO:0030864 ! cortical actin cytoskeleton
- Craniata
- GO:0005737 ! cytoplasm
- GO:0008092 ! cytoskeletal protein binding
- GO:0005856 ! cytoskeleton
e
m
n
p
- GO:0005886 ! plasma membrane
- GO:0030335 ! positive regulation of cell migration
- GO:0010628 ! positive regulation of gene expression
- GO:1903364 ! positive regulation of cellular protein catabolic process
- GO:2000643 ! positive regulation of early endosome to late endosome transport
- GO:1902966 ! positive regulation of protein localization to early endosome
- GO:1900087 ! positive regulation of G1/S transition of mitotic cell cycle
- Primates
- GO:0019904 ! protein domain specific binding
- GO:0042803 ! protein homodimerization activity
- GO:0010737 ! protein kinase A signaling
- GO:0051018 ! protein kinase A binding
- GO:0072659 ! protein localization to plasma membrane
r
- GO:0032231 ! regulation of actin filament bundle assembly
- GO:0008360 ! regulation of cell shape
- GO:1900027 ! regulation of ruffle assembly
- GO:0008361 ! regulation of cell size
- GO:0032487 ! regulation of Rap protein signal transduction
- GO:1902115 ! regulation of organelle assembly
- GO:0043087 ! regulation of GTPase activity
- GO:0003723 ! RNA binding
- GO:0001726 ! ruffle