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HUMAN:F5H1A7

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RDX
Protein Name(s) Radixin
External Links
UniProt F5H1A7
EMBL AP000901
AP002788
IPI IPI01009289
RefSeq NP_001247423.1
UniGene Hs.263671
Hs.584560
Hs.741211
ProteinModelPortal F5H1A7
SMR F5H1A7
PRIDE F5H1A7
Ensembl ENST00000544551
GeneID 5962
KEGG hsa:5962
UCSC uc010rwe.2
CTD 5962
HGNC HGNC:9944
KO K05762
ChiTaRS RDX
GenomeRNAi 5962
NextBio 23212
ArrayExpress F5H1A7
Bgee F5H1A7
GO GO:0005737
GO:0005856
GO:0019898
GO:0005886
Gene3D 1.20.80.10
2.30.29.30
InterPro IPR011259
IPR000798
IPR014352
IPR019748
IPR019747
IPR000299
IPR018980
IPR008954
IPR011993
Pfam PF00769
PF09380
PF00373
PRINTS PR00661
SUPFAM SSF47031
SSF48678
PROSITE PS00661
PS50057

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016477

cell migration

PMID:22467863[1]

ECO:0000315

P

Figure 1 suggests that depleting radixin decreases cell migration and increases cell area.

complete
CACAO 7881

GO:0005912

adherens junction

PMID:22467863[1]

ECO:0000315

C

Figure 3 shows that depletion of radixin increases adherens junctions which suggests that radixin has a role in this process.

complete
CACAO 7885

part_of

GO:0005902

microvillus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26043

C

Seeded From UniProt

complete

enables

GO:0045296

cadherin binding

PMID:25468996[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0072659

protein localization to plasma membrane

PMID:17825285[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903392

negative regulation of adherens junction organization

PMID:22467863[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034111

negative regulation of homotypic cell-cell adhesion

PMID:22467863[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032231

regulation of actin filament bundle assembly

PMID:22467863[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(GO:0071944)

Seeded From UniProt

complete

involved_in

GO:0008360

regulation of cell shape

PMID:22467863[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900027

regulation of ruffle assembly

PMID:22467863[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045792

negative regulation of cell size

PMID:22467863[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:22467863[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030864

cortical actin cytoskeleton

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

C

Seeded From UniProt

complete

part_of

GO:0030175

filopodium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

C

part_of:(CL:0002258)

Seeded From UniProt

complete

part_of

GO:0030027

lamellipodium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

C

part_of:(CL:0002258)

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

C

part_of:(CL:0002258)

Seeded From UniProt

complete

colocalizes_with

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

C

part_of:(CL:0002258)

Seeded From UniProt

complete

enables

GO:0051018

protein kinase A binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

F

occurs_in:(CL:0002258)

Seeded From UniProt

complete

involved_in

GO:1900087

positive regulation of G1/S transition of mitotic cell cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

P

  • results_in_division_of:(CL:0002258)
  • happens_during:(GO:0097067)

Seeded From UniProt

complete

involved_in

GO:0097067

cellular response to thyroid hormone stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

P

occurs_in:(CL:0002258)

Seeded From UniProt

complete

involved_in

GO:0045184

establishment of protein localization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

P

Seeded From UniProt

complete

involved_in

GO:0032487

regulation of Rap protein signal transduction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

P

Seeded From UniProt

complete

involved_in

GO:0010737

protein kinase A signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

P

Seeded From UniProt

complete

enables

GO:0051117

ATPase binding

PMID:17825285[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q92887

F

Seeded From UniProt

complete

enables

GO:0003779

actin binding

PMID:17825285[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:17825285[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002563)

Seeded From UniProt

complete

involved_in

GO:0008361

regulation of cell size

PMID:22467863[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15498,UniProtKB:P52735,UniProtKB:Q9UKW4

P

Seeded From UniProt

complete

involved_in

GO:0043087

regulation of GTPase activity

PMID:22467863[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15498,UniProtKB:P52735,UniProtKB:Q9UKW4

P

has_regulation_target:(UniProtKB:P63000)

Seeded From UniProt

complete

involved_in

GO:0008361

regulation of cell size

PMID:22467863[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P63000

P

Seeded From UniProt

complete

involved_in

GO:0034260

negative regulation of GTPase activity

PMID:22467863[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P63000)

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:16582480[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26043

F

Seeded From UniProt

complete

involved_in

GO:1902966

positive regulation of protein localization to early endosome

PMID:21148287[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15311
UniProtKB:P26038

P

has_regulation_target:(UniProtKB:P51149)

Seeded From UniProt

complete

involved_in

GO:1902115

regulation of organelle assembly

PMID:21148287[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15311
UniProtKB:P26038

P

results_in_maturation_of:(GO:0005770)

Seeded From UniProt

complete

involved_in

GO:2000643

positive regulation of early endosome to late endosome transport

PMID:21148287[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15311
UniProtKB:P26038

P

has_input:(UniProtKB:P00533)

Seeded From UniProt

complete

involved_in

GO:1903364

positive regulation of cellular protein catabolic process

PMID:21148287[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15311
UniProtKB:P26038

P

has_regulation_target:(UniProtKB:P00533)

Seeded From UniProt

complete

part_of

GO:0071944

cell periphery

PMID:22291017[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

PMID:21423176[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[8]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[9]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[10]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[11]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

involved_in

GO:0061028

establishment of endothelial barrier

PMID:23264465[12]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15311
UniProtKB:P26038

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:23264465[12]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q96S97

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16502470[13]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001914)

Seeded From UniProt

complete

colocalizes_with

GO:0005925

focal adhesion

PMID:21282464[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[15]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0051286

cell tip

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

involved_in

GO:0051016

barbed-end actin filament capping

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

P

Seeded From UniProt

complete

involved_in

GO:0045176

apical protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

P

Seeded From UniProt

complete

involved_in

GO:0036120

cellular response to platelet-derived growth factor stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

P

Seeded From UniProt

complete

part_of

GO:0032154

cleavage furrow

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

part_of

GO:0030496

midbody

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

part_of

GO:0030315

T-tubule

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

part_of

GO:0005913

cell-cell adherens junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

F

Seeded From UniProt

complete

involved_in

GO:1900087

positive regulation of G1/S transition of mitotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

P

Seeded From UniProt

complete

involved_in

GO:0097067

cellular response to thyroid hormone stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

P

Seeded From UniProt

complete

involved_in

GO:0045184

establishment of protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

P

Seeded From UniProt

complete

part_of

GO:0045177

apical part of cell

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

involved_in

GO:0045176

apical protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

F

Seeded From UniProt

complete

part_of

GO:0032420

stereocilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

part_of

GO:0030864

cortical actin cytoskeleton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

part_of

GO:0030175

filopodium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

involved_in

GO:0030033

microvillus assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

P

Seeded From UniProt

complete

part_of

GO:0030027

lamellipodium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

F

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

part_of

GO:0001726

ruffle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008954
InterPro:IPR011174

F

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000299

C

Seeded From UniProt

complete

enables

GO:0008092

cytoskeletal protein binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000798

F

Seeded From UniProt

complete

involved_in

GO:0051693

actin filament capping

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0117

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0293

C

Seeded From UniProt

complete

part_of

GO:0032154

cleavage furrow

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0467

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Valderrama, F et al. (2012) Radixin regulates cell migration and cell-cell adhesion through Rac1. J. Cell. Sci. 125 3310-9 PubMed GONUTS page
  2. Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Yang, Q et al. (2007) Ezrin and radixin both regulate the apical membrane localization of ABCC2 (MRP2) in human intestinal epithelial Caco-2 cells. Exp. Cell Res. 313 3517-25 PubMed GONUTS page
  4. Kitano, K et al. (2006) Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295-304. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 340-5 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Chirivino, D et al. (2011) The ERM proteins interact with the HOPS complex to regulate the maturation of endosomes. Mol. Biol. Cell 22 375-85 PubMed GONUTS page
  6. Fidalgo, M et al. (2012) Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress. J. Biol. Chem. 287 11556-65 PubMed GONUTS page
  7. Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
  8. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  9. Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  10. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  11. Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  12. 12.0 12.1 Aranda, JF et al. (2013) MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression. Mol. Biol. Cell 24 483-94 PubMed GONUTS page
  13. Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
  14. Coene, ED et al. (2011) A novel role for BRCA1 in regulating breast cancer cell spreading and motility. J. Cell Biol. 192 497-512 PubMed GONUTS page
  15. Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page