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HUMAN:ERP29
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ERP29 (synonyms: C12orf8, ERP28) | |
| Protein Name(s) | Endoplasmic reticulum resident protein 29
ERp29 Endoplasmic reticulum resident protein 28 ERp28 Endoplasmic reticulum resident protein 31 ERp31 | |
| External Links | ||
| UniProt | P30040 | |
| EMBL | X94910 AA412124 CR541667 AC073575 BC101493 BC101495 | |
| CCDS | CCDS44977.1 CCDS9158.1 | |
| PIR | T09549 | |
| RefSeq | NP_001029197.1 NP_006808.1 | |
| UniGene | Hs.75841 | |
| PDB | 2QC7 | |
| PDBsum | 2QC7 | |
| ProteinModelPortal | P30040 | |
| SMR | P30040 | |
| BioGrid | 116160 | |
| IntAct | P30040 | |
| MINT | MINT-5002525 | |
| STRING | 9606.ENSP00000261735 | |
| PhosphoSite | P30040 | |
| BioMuta | ERP29 | |
| DMDM | 6015110 | |
| OGP | P30040 | |
| REPRODUCTION-2DPAGE | IPI00024911 | |
| SWISS-2DPAGE | P30040 | |
| PaxDb | P30040 | |
| PeptideAtlas | P30040 | |
| PRIDE | P30040 | |
| Ensembl | ENST00000261735 ENST00000455836 | |
| GeneID | 10961 | |
| KEGG | hsa:10961 | |
| UCSC | uc001ttk.1 | |
| CTD | 10961 | |
| GeneCards | GC12P112451 | |
| HGNC | HGNC:13799 | |
| HPA | HPA039363 HPA039456 | |
| MIM | 602287 | |
| neXtProt | NX_P30040 | |
| PharmGKB | PA25509 | |
| eggNOG | NOG82861 | |
| GeneTree | ENSGT00390000018566 | |
| HOGENOM | HOG000169611 | |
| HOVERGEN | HBG051508 | |
| InParanoid | P30040 | |
| KO | K09586 | |
| OMA | GEKYKLD | |
| OrthoDB | EOG7XH6RH | |
| PhylomeDB | P30040 | |
| TreeFam | TF324701 | |
| ChiTaRS | ERP29 | |
| EvolutionaryTrace | P30040 | |
| GeneWiki | ERP29 | |
| GenomeRNAi | 10961 | |
| NextBio | 41652 | |
| PRO | PR:P30040 | |
| Proteomes | UP000005640 | |
| Bgee | P30040 | |
| CleanEx | HS_ERP29 | |
| ExpressionAtlas | P30040 | |
| Genevisible | P30040 | |
| GO | GO:0009986 GO:0005783 GO:0005788 GO:0070062 GO:0042470 GO:0016020 GO:0005790 GO:0030133 GO:0051087 GO:0042803 GO:0000187 GO:0006886 GO:0010629 GO:0050709 GO:0010628 GO:0001934 GO:0006457 GO:0009306 GO:0043335 GO:1902235 | |
| Gene3D | 1.20.1150.12 3.40.30.10 | |
| InterPro | IPR016855 IPR011679 IPR012883 IPR012336 | |
| Pfam | PF07749 PF07912 | |
| PIRSF | PIRSF027352 | |
| SUPFAM | SSF47933 SSF52833 | |
| PROSITE | PS00014 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0030133 |
transport vesicle |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005790 |
smooth endoplasmic reticulum |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051087 |
chaperone binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000187 |
activation of MAPK activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(PR:000003106) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(PR:000003106) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050709 |
negative regulation of protein secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P14780) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P05556)|has_regulation_target:(UniProtKB:Q03405)|has_regulation_target:(UniProtKB:P00533)|has_regulation_target:(UniProtKB:P30279) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q13217)|has_regulation_target:(UniProtKB:Q9NZJ5)|has_regulation_target:(UniProtKB:P11021) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043335 |
protein unfolding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006886 |
intracellular protein transport |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006457 |
protein folding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0003756 |
protein disulfide isomerase activity |
ECO:0000320 |
phylogenetic determination of loss of key residues evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004003 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051087 |
chaperone binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P52555 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P52555 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030133 |
transport vesicle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P52555 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005790 |
smooth endoplasmic reticulum |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P52555 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902235 |
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P57759 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P57759 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009306 |
protein secretion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042470 |
melanosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gao, D et al. (2012) ERp29 induces breast cancer cell growth arrest and survival through modulation of activation of p38 and upregulation of ER stress protein p58IPK. Lab. Invest. 92 200-13 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Ferrari, DM et al. (1998) ERp28, a human endoplasmic-reticulum-lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin-box motif. Eur. J. Biochem. 255 570-9 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Holbrook, LM et al. (2010) Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Br. J. Haematol. 148 627-37 PubMed GONUTS page
e
n
p
- GO:0010628 ! positive regulation of gene expression
- GO:0001934 ! positive regulation of protein phosphorylation
- Primates
- GO:0051087 ! protein-folding chaperone binding
- GO:0003756 ! protein disulfide isomerase activity
- GO:0006457 ! protein folding
- GO:0042803 ! protein homodimerization activity
- GO:0009306 ! protein secretion
- GO:0043335 ! protein unfolding
