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HUMAN:ENOG

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ENO2
Protein Name(s) Gamma-enolase

2-phospho-D-glycerate hydro-lyase Enolase 2 Neural enolase Neuron-specific enolase NSE

External Links
UniProt P09104
EMBL X13120
X14327
M36768
M22349
X51956
AK295220
BT007383
U47924
BC002745
CCDS CCDS8570.1
PIR JU0060
RefSeq NP_001966.1
UniGene Hs.511915
PDB 1TE6
2AKM
2AKZ
3UCC
3UCD
3UJE
3UJF
3UJR
3UJS
PDBsum 1TE6
2AKM
2AKZ
3UCC
3UCD
3UJE
3UJF
3UJR
3UJS
ProteinModelPortal P09104
SMR P09104
BioGrid 108340
IntAct P09104
MINT MINT-1367862
STRING 9606.ENSP00000229277
PhosphoSite P09104
DMDM 20981682
OGP P09104
UCD-2DPAGE P09104
MaxQB P09104
PaxDb P09104
PRIDE P09104
DNASU 2026
Ensembl ENST00000229277
ENST00000535366
ENST00000538763
ENST00000541477
GeneID 2026
KEGG hsa:2026
UCSC uc001qru.1
uc010sfq.1
CTD 2026
GeneCards GC12P007149
HGNC HGNC:3353
HPA CAB000063
MIM 131360
neXtProt NX_P09104
PharmGKB PA27788
eggNOG COG0148
GeneTree ENSGT00550000074560
HOGENOM HOG000072174
HOVERGEN HBG000067
InParanoid P09104
KO K01689
OMA HAKEATH
PhylomeDB P09104
TreeFam TF300391
BioCyc MetaCyc:HS10646-MONOMER
Reactome REACT_1383
REACT_1520
SABIO-RK P09104
UniPathway UPA00109
ChiTaRS ENO2
EvolutionaryTrace P09104
GeneWiki Enolase_2
GenomeRNAi 2026
NextBio 35479101
PMAP-CutDB P09104
PRO PR:P09104
Proteomes UP000005640
Bgee P09104
CleanEx HS_ENO2
ExpressionAtlas P09104
Genevestigator P09104
GO GO:0005829
GO:0005615
GO:0070062
GO:0043204
GO:0000015
GO:0001917
GO:0005886
GO:0000287
GO:0004634
GO:0005975
GO:0006094
GO:0006006
GO:0006096
GO:0044281
Gene3D 3.20.20.120
3.30.390.10
HAMAP MF_00318
InterPro IPR000941
IPR020810
IPR029065
IPR020809
IPR020811
IPR029017
PANTHER PTHR11902
Pfam PF00113
PF03952
PIRSF PIRSF001400
PRINTS PR00148
SUPFAM SSF51604
SSF54826
TIGRFAMs TIGR01060
PROSITE PS00164

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0043025

neuronal cell body

other:PMC3358374

ECO:0000314

C

Table 5 shows that the higher the NSE levels the greater the bad neurological outcome that was observed in patients, this was on day 0 of the study group. In addition, table 6 shows that that there was an increase in neurological worsening for patients in the study group who were administered 25.1-35ng/ml of NSE as shown in the "Yes" category. Futhermore in Figure 1, it shows that the levels of NSE between the controls and study group, in which the study group had a higher level of NSE and thus as shown in the previous tables had more severe neurological function.

complete
CACAO 8110

enables

GO:0004634

phosphopyruvate hydratase activity

PMID:22087329[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00925

F

Seeded From UniProt

complete

involved_in

GO:0006096

glycolytic process

PMID:22087329[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00925

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19433310[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:22664934[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001827)

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17183
ensembl:ENSMUSP00000004378

C

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17183
ensembl:ENSMUSP00000004378

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17183
ensembl:ENSMUSP00000004378

C

Seeded From UniProt

complete

part_of

GO:0001917

photoreceptor inner segment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17183
ensembl:ENSMUSP00000004378

C

Seeded From UniProt

complete

part_of

GO:0000015

phosphopyruvate hydratase complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000941

C

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000941

F

Seeded From UniProt

complete

enables

GO:0004634

phosphopyruvate hydratase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000941

F

Seeded From UniProt

complete

involved_in

GO:0006096

glycolytic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000941

P

Seeded From UniProt

complete

enables

GO:0004634

phosphopyruvate hydratase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.2.1.11

F

Seeded From UniProt

complete

enables

GO:0004634

phosphopyruvate hydratase activity

PMID:2045099[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0061621

canonical glycolysis

Reactome:R-HSA-70171

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006094

gluconeogenesis

Reactome:R-HSA-70263

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-71660
Reactome:R-HSA-70494

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0006096

glycolytic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0324
UniPathway:UPA00109

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Floden, AM et al. (2011) Borrelia burgdorferi enolase is a surface-exposed plasminogen binding protein. PLoS ONE 6 e27502 PubMed GONUTS page
  2. ↑ Obermajer, N et al. () Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells. Int. J. Biochem. Cell Biol. 41 1685-96 PubMed GONUTS page
  3. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  4. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  5. ↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
  6. ↑ Oliva, D et al. (1991) Complete structure of the human gene encoding neuron-specific enolase. Genomics 10 157-65 PubMed GONUTS page
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