GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:ELOV6

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ELOVL6 (synonyms: FACE, LCE)
Protein Name(s) Elongation of very long chain fatty acids protein 6

3-keto acyl-CoA synthase ELOVL6 ELOVL fatty acid elongase 6 ELOVL FA elongase 6 Fatty acid elongase 2 hELO2 Fatty acyl-CoA elongase Long-chain fatty-acyl elongase Very-long-chain 3-oxoacyl-CoA synthase 6

External Links
UniProt Q9H5J4
EMBL AK074813
AK027031
AC004050
AC093770
BC001305
CCDS CCDS3690.1
RefSeq NP_001124193.1
NP_076995.1
UniGene Hs.412939
Hs.652828
ProteinModelPortal Q9H5J4
BioGrid 122522
STRING 9606.ENSP00000304736
BindingDB Q9H5J4
ChEMBL CHEMBL5704
PhosphoSite Q9H5J4
DMDM 74733585
MaxQB Q9H5J4
PaxDb Q9H5J4
PRIDE Q9H5J4
Ensembl ENST00000302274
ENST00000394607
GeneID 79071
KEGG hsa:79071
UCSC uc003hzz.3
CTD 79071
GeneCards GC04M110968
HGNC HGNC:15829
HPA HPA042355
MIM 611546
neXtProt NX_Q9H5J4
PharmGKB PA134939058
eggNOG NOG305096
GeneTree ENSGT00760000119122
HOGENOM HOG000038943
HOVERGEN HBG099423
InParanoid Q9H5J4
KO K10203
OMA HGQCHSH
OrthoDB EOG7MKW6F
PhylomeDB Q9H5J4
TreeFam TF106467
BioCyc MetaCyc:HS10142-MONOMER
Reactome REACT_147904
REACT_380
GenomeRNAi 79071
NextBio 67857
PRO PR:Q9H5J4
Proteomes UP000005640
Bgee Q9H5J4
CleanEx HS_ELOVL6
ExpressionAtlas Q9H5J4
Genevestigator Q9H5J4
GO GO:0005783
GO:0005789
GO:0030176
GO:0016747
GO:0044255
GO:0019367
GO:0042759
GO:0035338
GO:0044281
GO:0019432
InterPro IPR002076
PANTHER PTHR11157
Pfam PF01151
PROSITE PS01188

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

PMID:26628376[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q920L5

P

Seeded From UniProt

complete

involved_in

GO:0042759

long-chain fatty acid biosynthetic process

PMID:20937905[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019367

fatty acid elongation, saturated fatty acid

PMID:20937905[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:20937905[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042761

very long-chain fatty acid biosynthetic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037762
FB:FBgn0260942
MGI:MGI:1195976
MGI:MGI:1858960
PANTHER:PTN000125390
RGD:620583
SGD:S000000630
SGD:S000004364
UniProtKB:A1L3X0
UniProtKB:Q9BW60
UniProtKB:Q9GZR5
UniProtKB:Q9HB03
UniProtKB:Q9NXB9
UniProtKB:Q9NYP7
ZFIN:ZDB-GENE-060421-5612

P

Seeded From UniProt

complete

involved_in

GO:0034626

fatty acid elongation, polyunsaturated fatty acid

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1858960
PANTHER:PTN000125390
RGD:620583
UniProtKB:A1L3X0
UniProtKB:E1BYE9
UniProtKB:E3VVZ8
UniProtKB:Q9HB03
UniProtKB:Q9NXB9
UniProtKB:Q9NYP7

P

Seeded From UniProt

complete

involved_in

GO:0034625

fatty acid elongation, monounsaturated fatty acid

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1195976
PANTHER:PTN000125390
RGD:620585
UniProtKB:Q9BW60
UniProtKB:Q9HB03
UniProtKB:Q9NYP7
dictyBase:DDB_G0292896

P

Seeded From UniProt

complete

part_of

GO:0030176

integral component of endoplasmic reticulum membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2156528
PANTHER:PTN000125390
UniProtKB:Q9GZR5

C

Seeded From UniProt

complete

involved_in

GO:0030148

sphingolipid biosynthetic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1858959
PANTHER:PTN000125390
SGD:S000000630
SGD:S000004364
UniProtKB:Q9BW60

P

Seeded From UniProt

complete

involved_in

GO:0019367

fatty acid elongation, saturated fatty acid

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1195976
PANTHER:PTN000125390
RGD:620585
UniProtKB:A1L3X0
UniProtKB:Q9BW60
UniProtKB:Q9GZR5
UniProtKB:Q9H5J4
UniProtKB:Q9HB03

P

Seeded From UniProt

complete

enables

GO:0009922

fatty acid elongase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037762
FB:FBgn0052072
FB:FBgn0260942
MGI:MGI:1858960
MGI:MGI:1933331
PANTHER:PTN000125390
RGD:620583
RGD:620585
SGD:S000000630
SGD:S000003732
SGD:S000004364
TAIR:locus:2115395
UniProtKB:A1L3X0
UniProtKB:E1BYE9
UniProtKB:E3VVZ8
UniProtKB:Q9BW60
UniProtKB:Q9HB03
UniProtKB:Q9NXB9
UniProtKB:Q9NYP7
ZFIN:ZDB-GENE-040407-2
dictyBase:DDB_G0292896

F

Seeded From UniProt

complete

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920L5
ensembl:ENSMUSP00000071351

P

Seeded From UniProt

complete

involved_in

GO:0030497

fatty acid elongation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920L5
ensembl:ENSMUSP00000071351

P

Seeded From UniProt

complete

part_of

GO:0030176

integral component of endoplasmic reticulum membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920L5
ensembl:ENSMUSP00000071351

C

Seeded From UniProt

complete

enables

GO:0016747

transferase activity, transferring acyl groups other than amino-acyl groups

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920L5
ensembl:ENSMUSP00000071351

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033675

C

Seeded From UniProt

complete

enables

GO:0009922

fatty acid elongase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033675

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002076

C

Seeded From UniProt

complete

involved_in

GO:0019367

fatty acid elongation, saturated fatty acid

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033675

P

Seeded From UniProt

complete

involved_in

GO:0042761

very long-chain fatty acid biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033675

P

Seeded From UniProt

complete

enables

GO:0102336

3-oxo-arachidoyl-CoA synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.1.199

F

Seeded From UniProt

complete

enables

GO:0102756

very-long-chain 3-ketoacyl-CoA synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.1.199

F

Seeded From UniProt

complete

enables

GO:0102337

3-oxo-cerotoyl-CoA synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.1.199

F

Seeded From UniProt

complete

enables

GO:0102338

3-oxo-lignoceronyl-CoA synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.1.199

F

Seeded From UniProt

complete

involved_in

GO:0034625

fatty acid elongation, monounsaturated fatty acid

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000254923

P

Seeded From UniProt

complete

involved_in

GO:0035338

long-chain fatty-acyl-CoA biosynthetic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000254923

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000254923

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000254923

C

Seeded From UniProt

complete

involved_in

GO:0019367

fatty acid elongation, saturated fatty acid

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000254923

P

Seeded From UniProt

complete

involved_in

GO:0006636

unsaturated fatty acid biosynthetic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000254923

P

Seeded From UniProt

complete

enables

GO:0009922

fatty acid elongase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000254923

F

Seeded From UniProt

complete

involved_in

GO:0045540

regulation of cholesterol biosynthetic process

Reactome:R-HSA-1655829

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035338

long-chain fatty-acyl-CoA biosynthetic process

Reactome:R-HSA-75876

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

Reactome:R-HSA-548814
Reactome:R-HSA-1655835

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0275
UniPathway:UPA00094

P

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Tan, CY et al. (2015) Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6. Cell Rep 13 2039-47 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Ohno, Y et al. (2010) ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. Proc. Natl. Acad. Sci. U.S.A. 107 18439-44 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:ELOV6&oldid=5955201"