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HUMAN:EFNB1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) EFNB1 (synonyms: EFL3, EPLG2, LERK2)
Protein Name(s) Ephrin-B1

EFL-3 ELK ligand ELK-L EPH-related receptor tyrosine kinase ligand 2 LERK-2

External Links
UniProt P98172
EMBL U09304
L37361
U09303
AL136092
CH471132
CH471132
BC016649
BC052979
CCDS CCDS14391.1
PIR S46993
RefSeq NP_004420.1
UniGene Hs.144700
ProteinModelPortal P98172
SMR P98172
BioGrid 108267
IntAct P98172
STRING 9606.ENSP00000204961
PhosphoSite P98172
DMDM 1706668
MaxQB P98172
PaxDb P98172
PeptideAtlas P98172
PRIDE P98172
DNASU 1947
Ensembl ENST00000204961
GeneID 1947
KEGG hsa:1947
UCSC uc004dxd.4
CTD 1947
GeneCards GC0XP068048
HGNC HGNC:3226
HPA CAB031489
MIM 300035
304110
neXtProt NX_P98172
Orphanet 1520
PharmGKB PA27661
eggNOG NOG262190
GeneTree ENSGT00390000005839
HOGENOM HOG000220931
HOVERGEN HBG051448
InParanoid P98172
KO K05463
OMA PDSFFNS
OrthoDB EOG7288S5
PhylomeDB P98172
Reactome REACT_228085
REACT_228170
REACT_228189
REACT_228226
SignaLink P98172
ChiTaRS EFNB1
GeneWiki EFNB1
GenomeRNAi 1947
NextBio 7891
PMAP-CutDB P98172
PRO PR:P98172
Proteomes UP000005640
Bgee P98172
CleanEx HS_EFNB1
Genevestigator P98172
GO GO:0005737
GO:0070062
GO:0005887
GO:0045121
GO:0005634
GO:0005886
GO:0045202
GO:0046875
GO:0007411
GO:0007155
GO:0007267
GO:0009880
GO:0048013
GO:0001755
GO:0042102
Gene3D 2.60.40.420
InterPro IPR008972
IPR001799
IPR019765
PANTHER PTHR11304
Pfam PF00812
PRINTS PR01347
ProDom PD002533
SUPFAM SSF49503
PROSITE PS01299
PS51551

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:19056867[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P52796

C

Seeded From UniProt

complete

involved_in

GO:0048013

ephrin receptor signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102707
MGI:MGI:103236
MGI:MGI:106644
MGI:MGI:107444
PANTHER:PTN000885159
UniProtKB:P20827
UniProtKB:P52797
UniProtKB:P52799
UniProtKB:P52803
UniProtKB:Q15768
WB:WBGene00006869

P

Seeded From UniProt

complete

enables

GO:0046875

ephrin receptor binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040324
MGI:MGI:102707
MGI:MGI:102708
MGI:MGI:106644
MGI:MGI:107444
PANTHER:PTN000885159
RGD:620391
UniProtKB:P20827
UniProtKB:P52797
UniProtKB:P52798
UniProtKB:P52799
UniProtKB:P52803
UniProtKB:Q15768
WB:WBGene00006869

F

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040324
MGI:MGI:102708
MGI:MGI:107444
MGI:MGI:109196
PANTHER:PTN000885159
RGD:620389

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:105097
MGI:MGI:107444
PANTHER:PTN000885159
UniProtKB:P52799
UniProtKB:P98172
UniProtKB:Q15768

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046875

ephrin receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52795
ensembl:ENSMUSP00000050716

F

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52795
ensembl:ENSMUSP00000050716

C

Seeded From UniProt

complete

involved_in

GO:0042102

positive regulation of T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52795
ensembl:ENSMUSP00000050716

P

Seeded From UniProt

complete

involved_in

GO:0031295

T cell costimulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52795
ensembl:ENSMUSP00000050716

P

Seeded From UniProt

complete

involved_in

GO:0009880

embryonic pattern specification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52795
ensembl:ENSMUSP00000050716

P

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52795
ensembl:ENSMUSP00000050716

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52795
ensembl:ENSMUSP00000050716

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52795
ensembl:ENSMUSP00000050716

C

Seeded From UniProt

complete

involved_in

GO:0001755

neural crest cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P52795
ensembl:ENSMUSP00000050716

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001799
InterPro:IPR019765

C

Seeded From UniProt

complete

enables

GO:0046875

ephrin receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034255

F

Seeded From UniProt

complete

involved_in

GO:0048013

ephrin receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034255

P

Seeded From UniProt

complete

enables

GO:0046875

ephrin receptor binding

PMID:8798744[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007267

cell-cell signaling

PMID:8798744[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:8798744[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:8660976[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0048013

ephrin receptor signaling pathway

Reactome:R-HSA-2682334

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-4093339
Reactome:R-HSA-4093336
Reactome:R-HSA-4093332
Reactome:R-HSA-4093331
Reactome:R-HSA-4093329
Reactome:R-HSA-3928657
Reactome:R-HSA-3928654
Reactome:R-HSA-3928645
Reactome:R-HSA-3928641
Reactome:R-HSA-3928640
Reactome:R-HSA-3928639
Reactome:R-HSA-3928633
Reactome:R-HSA-3928631
Reactome:R-HSA-3928628
Reactome:R-HSA-3928627
Reactome:R-HSA-3928625
Reactome:R-HSA-3928624
Reactome:R-HSA-3928617
Reactome:R-HSA-3928615
Reactome:R-HSA-3928614
Reactome:R-HSA-3928612
Reactome:R-HSA-3928607
Reactome:R-HSA-3928604
Reactome:R-HSA-3928601
Reactome:R-HSA-3928598
Reactome:R-HSA-3928597
Reactome:R-HSA-3928595
Reactome:R-HSA-3928592
Reactome:R-HSA-3928591
Reactome:R-HSA-3928578

ECO:0000304

author statement supported by traceable reference used in manual assertion






























C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0370

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Böhme, B et al. (1996) Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity. J. Biol. Chem. 271 24747-52 PubMed GONUTS page
  4. ↑ Cerretti, DP et al. (1996) The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. Genomics 33 277-82 PubMed GONUTS page
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