HUMAN:EEA1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	EEA1 (synonyms: ZFYVE2)
Protein Name(s)	Early endosome antigen 1 Endosome-associated protein p162 Zinc finger FYVE domain-containing protein 2
External Links
UniProt	Q15075
EMBL	L40157 X78998 AC016136 AC021646 AC026111
CCDS	CCDS31874.1
PIR	A57013
RefSeq	NP_003557.2
UniGene	Hs.567367
PDB	1HYI 1HYJ 1JOC 3MJH
PDBsum	1HYI 1HYJ 1JOC 3MJH
ProteinModelPortal	Q15075
SMR	Q15075
BioGrid	113999
CORUM	Q15075
IntAct	Q15075
MINT	Q15075
STRING	9606.ENSP00000317955
iPTMnet	Q15075
PhosphoSitePlus	Q15075
SwissPalm	Q15075
BioMuta	EEA1
DMDM	229462866
EPD	Q15075
MaxQB	Q15075
PaxDb	Q15075
PeptideAtlas	Q15075
PRIDE	Q15075
ProteomicsDB	60427
DNASU	8411
Ensembl	ENST00000322349
GeneID	8411
KEGG	hsa:8411
UCSC	uc001tck.4
CTD	8411
DisGeNET	8411
EuPathDB	HostDB:ENSG00000102189.16
GeneCards	EEA1
HGNC	HGNC:3185
HPA	CAB005861 CAB018782 HPA038158 HPA038159
MIM	605070
neXtProt	NX_Q15075
OpenTargets	ENSG00000102189
PharmGKB	PA27621
eggNOG	ENOG410IFA7 ENOG4111F3Q
GeneTree	ENSGT00910000144126
HOGENOM	HOG000112329
HOVERGEN	HBG039440
InParanoid	Q15075
KO	K12478
OMA	FIAVYQH
OrthoDB	EOG091G01M6
PhylomeDB	Q15075
TreeFam	TF329698
Reactome	R-HSA-168138
SIGNOR	Q15075
ChiTaRS	EEA1
EvolutionaryTrace	Q15075
GeneWiki	EEA1
GenomeRNAi	8411
PMAP-CutDB	Q15075
PRO	PR:Q15075
Proteomes	UP000005640
Bgee	ENSG00000102189
CleanEx	HS_EEA1
ExpressionAtlas	Q15075
Genevisible	Q15075
GO	GO:0044308 GO:0005737 GO:0005829 GO:0005769 GO:0031901 GO:0070062 GO:0019897 GO:0016020 GO:0098793 GO:0055037 GO:0005969 GO:0005545 GO:0005516 GO:0030742 GO:0003676 GO:0042803 GO:0008270 GO:0045022 GO:0006897 GO:0016189 GO:0006906 GO:0039694
Gene3D	3.30.40.10
InterPro	IPR013087 IPR000306 IPR017455 IPR011011 IPR013083
Pfam	PF01363
SMART	SM00064
SUPFAM	SSF57903
PROSITE	PS50178 PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0039694	viral RNA genome replication	PMID:19376974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:22719997^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:18767904^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0045022	early endosome to late endosome transport	PMID:7768953^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:11741531^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030742	GTP-dependent protein binding	PMID:10491193^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0019897	extrinsic component of plasma membrane	PMID:7768953^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006906	vesicle fusion	PMID:9697774^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	PMID:21081650^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:7768953^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:15792797^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:15880641^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:11741531^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005545	1-phosphatidylinositol binding	PMID:11256955^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:11741531^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:25327288^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:19535332^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:18388320^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:16542649^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:15229288^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:12536145^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044308	axonal spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BL66 ensembl:ENSMUSP00000061493	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BL66 ensembl:ENSMUSP00000061493	C		Seeded From UniProt	complete
part_of	GO:0005969	serine-pyruvate aminotransferase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BL66 ensembl:ENSMUSP00000061493	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BL66 ensembl:ENSMUSP00000061493	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BL66 ensembl:ENSMUSP00000061493	C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K051 ensembl:ENSRNOP00000071305	C		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000306	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:7768953^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:7768953^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:7768953^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005545	1-phosphatidylinositol binding	PMID:9697774^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016189	synaptic vesicle to endosome fusion	PMID:11741531^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:11741531^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Berger, KL et al. (2009) Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. Proc. Natl. Acad. Sci. U.S.A. 106 7577-82 PubMed GONUTS page
↑ Pons, V et al. (2012) SNX12 role in endosome membrane transport. PLoS ONE 7 e38949 PubMed GONUTS page
↑ Pons, V et al. (2008) Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol. 6 e214 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Mu, FT et al. (1995) EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif. J. Biol. Chem. 270 13503-11 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Dumas, JJ et al. (2001) Multivalent endosome targeting by homodimeric EEA1. Mol. Cell 8 947-58 PubMed GONUTS page
↑ Callaghan, J et al. (1999) Direct interaction of EEA1 with Rab5b. Eur. J. Biochem. 265 361-6 PubMed GONUTS page
↑ ^8.0 ^8.1 Simonsen, A et al. (1998) EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 394 494-8 PubMed GONUTS page
↑ Krag, C et al. (2010) PI3KC2α, a class II PI3K, is required for dynamin-independent internalization pathways. J. Cell. Sci. 123 4240-50 PubMed GONUTS page
↑ Johnson, DM et al. (2005) Regulation of divalent metal transporter expression in human intestinal epithelial cells following exposure to non-haem iron. FEBS Lett. 579 1923-9 PubMed GONUTS page
↑ Gruper, Y et al. (2005) Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells. J. Cell. Physiol. 204 901-12 PubMed GONUTS page
↑ Cheung, PC et al. (2001) Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi. Biochem. J. 355 113-21 PubMed GONUTS page
↑ Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page
↑ Giles, LM et al. (2009) Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis. J. Biol. Chem. 284 21765-75 PubMed GONUTS page
↑ Mukai, A et al. (2008) Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis. J. Cell. Sci. 121 1325-33 PubMed GONUTS page
↑ Ahtiainen, L et al. (2006) Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing. Exp. Cell Res. 312 1540-53 PubMed GONUTS page
↑ Coumailleau, F et al. (2004) Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol. Biol. Cell 15 4444-56 PubMed GONUTS page
↑ Gurung, R et al. (2003) Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. J. Biol. Chem. 278 11376-85 PubMed GONUTS page

[PMID:19376974-1] Berger, KL et al. (2009) Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. Proc. Natl. Acad. Sci. U.S.A. 106 7577-82 PubMed GONUTS page

[PMID:22719997-2] Pons, V et al. (2012) SNX12 role in endosome membrane transport. PLoS ONE 7 e38949 PubMed GONUTS page

[PMID:18767904-3] Pons, V et al. (2008) Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol. 6 e214 PubMed GONUTS page

[PMID:19056867-4] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:7768953-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Mu, FT et al. (1995) EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif. J. Biol. Chem. 270 13503-11 PubMed GONUTS page

[PMID:11741531-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Dumas, JJ et al. (2001) Multivalent endosome targeting by homodimeric EEA1. Mol. Cell 8 947-58 PubMed GONUTS page

[PMID:10491193-7] Callaghan, J et al. (1999) Direct interaction of EEA1 with Rab5b. Eur. J. Biochem. 265 361-6 PubMed GONUTS page

[PMID:9697774-8] 8.0 ^8.1 Simonsen, A et al. (1998) EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 394 494-8 PubMed GONUTS page

[PMID:21081650-9] Krag, C et al. (2010) PI3KC2α, a class II PI3K, is required for dynamin-independent internalization pathways. J. Cell. Sci. 123 4240-50 PubMed GONUTS page

[PMID:15792797-10] Johnson, DM et al. (2005) Regulation of divalent metal transporter expression in human intestinal epithelial cells following exposure to non-haem iron. FEBS Lett. 579 1923-9 PubMed GONUTS page

[PMID:15880641-11] Gruper, Y et al. (2005) Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells. J. Cell. Physiol. 204 901-12 PubMed GONUTS page

[PMID:11256955-12] Cheung, PC et al. (2001) Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi. Biochem. J. 355 113-21 PubMed GONUTS page

[PMID:25327288-13] Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page

[PMID:19535332-14] Giles, LM et al. (2009) Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis. J. Biol. Chem. 284 21765-75 PubMed GONUTS page

[PMID:18388320-15] Mukai, A et al. (2008) Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis. J. Cell. Sci. 121 1325-33 PubMed GONUTS page

[PMID:16542649-16] Ahtiainen, L et al. (2006) Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing. Exp. Cell Res. 312 1540-53 PubMed GONUTS page

[PMID:15229288-17] Coumailleau, F et al. (2004) Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol. Biol. Cell 15 4444-56 PubMed GONUTS page

[PMID:12536145-18] Gurung, R et al. (2003) Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. J. Biol. Chem. 278 11376-85 PubMed GONUTS page

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HUMAN:EEA1

Contents

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Notes

References

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