HUMAN:DYR1A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DYRK1A (synonyms: DYRK, MNB, MNBH)
Protein Name(s)	Dual specificity tyrosine-phosphorylation-regulated kinase 1A Dual specificity YAK1-related kinase HP86 Protein kinase minibrain homolog MNBH hMNB
External Links
UniProt	Q13627
EMBL	U58496 U52373 D85759 D86550 AF108830 AJ001870
CCDS	CCDS13653.1 CCDS13654.1 CCDS42925.1 CCDS42926.1
PIR	JC4898
RefSeq	NP_001334650.1 NP_001334651.1 NP_001387.2 NP_567824.1 NP_569120.1 NP_569122.1 XP_006724039.1 XP_006724040.1 XP_006724041.1 XP_011527785.1 XP_016883773.1
UniGene	Hs.368240
PDB	2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK
PDBsum	2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK
ProteinModelPortal	Q13627
SMR	Q13627
BioGrid	108192
DIP	DIP-39750N
IntAct	Q13627
MINT	MINT-1205413
STRING	9606.ENSP00000381932
BindingDB	Q13627
ChEMBL	CHEMBL2292
DrugBank	DB07608
GuidetoPHARMACOLOGY	2009
iPTMnet	Q13627
PhosphoSitePlus	Q13627
BioMuta	DYRK1A
DMDM	3219996
EPD	Q13627
MaxQB	Q13627
PaxDb	Q13627
PeptideAtlas	Q13627
PRIDE	Q13627
DNASU	1859
Ensembl	ENST00000338785 ENST00000339659 ENST00000398956 ENST00000398960
GeneID	1859
KEGG	hsa:1859
UCSC	uc002ywi.4
CTD	1859
DisGeNET	1859
GeneCards	DYRK1A
HGNC	HGNC:3091
HPA	HPA015323 HPA015810
MalaCards	DYRK1A
MIM	600855 614104
neXtProt	NX_Q13627
OpenTargets	ENSG00000157540
Orphanet	178469
PharmGKB	PA27545
eggNOG	KOG0667 ENOG410XPET
GeneTree	ENSGT00760000119032
HOGENOM	HOG000220863
HOVERGEN	HBG051425
InParanoid	Q13627
KO	K08825
OMA	RQGIDRE
OrthoDB	EOG091G03J7
PhylomeDB	Q13627
TreeFam	TF314624
BRENDA	2.7.12.1
Reactome	[www.reactome.org/content/detail/R-HSA-1538133 R-HSA-1538133]
SignaLink	Q13627
SIGNOR	Q13627
ChiTaRS	DYRK1A
EvolutionaryTrace	Q13627
GeneWiki	DYRK1A
GenomeRNAi	1859
PRO	PR:Q13627
Proteomes	UP000005640
Bgee	ENSG00000157540
CleanEx	HS_DYRK1A
ExpressionAtlas	Q13627
Genevisible	Q13627
GO	GO:0030529 GO:0016607 GO:0005654 GO:0005634 GO:0005524 GO:0004715 GO:0004672 GO:0043621 GO:0004674 GO:0004712 GO:0004713 GO:0048156 GO:0007623 GO:0043518 GO:0048025 GO:0007399 GO:0018105 GO:0018107 GO:0018108 GO:0090312 GO:0046777 GO:0006468 GO:0000381 GO:0016032
InterPro	IPR028318 IPR011009 IPR000719 IPR017441 IPR008271
PANTHER	PTHR24058:SF68
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	PMID:28400201^[1]	ECO:0000314			C		HUMAN DYR1A (DYRK1A) // “DYRK1A was localized in the nucleus and in the cytoplasm including the virion assembly complex (cVAC; Fig. 1A, Fig. S1 and Fig. S2, indicated by yellow arrows).”	complete CACAO 12866
	GO:0072517	host cell viral assembly compartment	PMID:28400201^[1]	ECO:0000314			C		HUMAN DYR1A (DYRK1A) // “DYRK1A was localized in the nucleus and in the cytoplasm including the virion assembly complex (cVAC; Fig. 1A, Fig. S1 and Fig. S2, indicated by yellow arrows).	complete CACAO 12869
	GO:0005737	cytoplasm	PMID:28400201^[1]	ECO:0000314			C		HUMAN DYR1A (DYRK1A) // “DYRK1A was localized in the nucleus and in the cytoplasm including the virion assembly complex (cVAC; Fig. 1A, Fig. S1 and Fig. S2, indicated by yellow arrows).”	complete CACAO 12871
enables	GO:0048156	tau protein binding	PMID:17906291^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0031115	negative regulation of microtubule polymerization	PMID:17906291^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:17906291^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61214	F	has_input:(UniProtKB:P10636) occurs_in:(CL:1001571)\|has_input(UniProtKB:P10636) occurs_in:(UBERON:0001870)\|has_input(UniProtKB:P10636) occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:0034205	amyloid-beta formation	PMID:25556849^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_output:(UniProtKB:P05067:PRO_0000000093)	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:25556849^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63470	P	has_input:(UniProtKB:P10636-8) occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:25556849^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9Y463	P	has_input:(UniProtKB:P10636-8) occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:25556849^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9Y463	F	has_input:(UniProtKB:P10636-8) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63470	P	has_input:(UniProtKB:Q16629)	Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:24327345^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(GO:0005829)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	C	part_of:(CL:0000540) part_of:(UBERON:0003881)	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	C	part_of:(CL:0000598) part_of:(UBERON:0001950)\|part_of:(CL:0000108)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	C	part_of:(CL:0000540) part_of:(UBERON:0001950)\|part_of:(CL:0000540) part_of:(UBERON:0003881)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	C	part_of:(CL:0012000) part_of:(UBERON:0001893)\|part_of:(CL:0000540) part_of:(UBERON:0001893)\|part_of:(CL:0000598) part_of:(UBERON:0003882) part_of:(UBERON:0003883)\|part_of:(CL:0000120) part_of:(UBERON:0001885)\|part_of:(CL:0000681) part_of:(UBERON:0001885)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:28386764^[5]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15694837^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15694837^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:28386764^[5]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:28386764^[5]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23415227^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005856	cytoskeleton	PMID:24327345^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0033120	positive regulation of RNA splicing	PMID:28377597^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(ENSEMBL:ENSG00000186868)	Seeded From UniProt	complete
involved_in	GO:0090312	positive regulation of protein deacetylation	PMID:20736167^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	P	has_regulation_target:(UniProtKB:P04637)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:20736167^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	F		Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	PMID:20736167^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:20736167^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:20736167^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63470	P		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63470	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63470	C		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63470	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63470	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63470	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61214	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63470	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:9748265^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:9748265^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	C		Seeded From UniProt	complete
involved_in	GO:0090312	positive regulation of protein deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	P		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	F		Seeded From UniProt	complete
involved_in	GO:0048025	negative regulation of mRNA splicing, via spliceosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	P		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	F		Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	F		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	P		Seeded From UniProt	complete
involved_in	GO:0031115	negative regulation of microtubule polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	C		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61214 ensembl:ENSMUSP00000113660	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63470 ensembl:ENSRNOP00000042446	P		Seeded From UniProt	complete
involved_in	GO:0033120	positive regulation of RNA splicing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63470 ensembl:ENSRNOP00000042446	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63470 ensembl:ENSRNOP00000042446	P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63470 ensembl:ENSRNOP00000042446	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63470 ensembl:ENSRNOP00000042446	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63470 ensembl:ENSRNOP00000042446	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63470 ensembl:ENSRNOP00000042446	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63470 ensembl:ENSRNOP00000042446	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63470 ensembl:ENSRNOP00000042446	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63470 ensembl:ENSRNOP00000042446	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63470 ensembl:ENSRNOP00000042446	F		Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63470 ensembl:ENSRNOP00000042446	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028318	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR028318	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028318	P		Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.12.1	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23665168^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13627-1	F		Seeded From UniProt	complete
colocalizes_with	GO:0005883	neurofilament	PMID:24327345^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12036	C		Seeded From UniProt	complete
colocalizes_with	GO:0005884	actin filament	PMID:24327345^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60709	C		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	PMID:24327345^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P68366	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:24327345^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60709	F		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	PMID:24327345^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12036	F		Seeded From UniProt	complete
colocalizes_with	GO:0005874	microtubule	PMID:24327345^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P68366	C		Seeded From UniProt	complete
involved_in	GO:0036289	peptidyl-serine autophosphorylation	PMID:24327345^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	causally_upstream_of:(GO:0033674)	Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:24327345^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	positively_regulates:(GO:0016301)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:24327345^[4] PMID:28377597^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:O43426)\|has_input:(UniProtKB:P49418)\|has_input:(UniProtKB:P10636)\|has_input:(UniProtKB:P46821)\|has_input:(UniProtKB:P37840)	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:28377597^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24327345^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:8769099^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9070862^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8769099^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:8975710^[14] PMID:8769099^[12] Reactome:R-HSA-1362270	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-1362270	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Hutterer, C et al. (2017) Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity. Antiviral Res. PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Ryoo, SR et al. (2007) DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease. J. Biol. Chem. 282 34850-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Coutadeur, S et al. (2015) A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro. J. Neurochem. 133 440-51 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 Kaczmarski, W et al. (2014) Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). J. Neurosci. Res. 92 162-73 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ ^6.0 ^6.1 Bescond, M & Rahmani, Z (2005) Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA alpha-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein. Int. J. Biochem. Cell Biol. 37 775-83 PubMed GONUTS page
↑ Wippich, F et al. (2013) Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling. Cell 152 791-805 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Yin, X et al. (2017) Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice. Sci Rep 7 619 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Li, D et al. (2010) Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions. J. Biol. Chem. 285 35374-85 PubMed GONUTS page
↑ ^10.0 ^10.1 Becker, W et al. (1998) Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J. Biol. Chem. 273 25893-902 PubMed GONUTS page
↑ Soundararajan, M et al. (2013) Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition. Structure 21 986-96 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Shindoh, N et al. (1996) Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21. Biochem. Biophys. Res. Commun. 225 92-9 PubMed GONUTS page
↑ Song, WJ et al. (1997) The murine Dyrk protein maps to chromosome 16, localizes to the nucleus, and can form multimers. Biochem. Biophys. Res. Commun. 231 640-4 PubMed GONUTS page
↑ Song, WJ et al. (1996) Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region". Genomics 38 331-9 PubMed GONUTS page

[PMID:28400201-1] 1.0 ^1.1 ^1.2 Hutterer, C et al. (2017) Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity. Antiviral Res. PubMed GONUTS page

[PMID:17906291-2] 2.0 ^2.1 ^2.2 Ryoo, SR et al. (2007) DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease. J. Biol. Chem. 282 34850-7 PubMed GONUTS page

[PMID:25556849-3] 3.0 ^3.1 ^3.2 ^3.3 Coutadeur, S et al. (2015) A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro. J. Neurochem. 133 440-51 PubMed GONUTS page

[PMID:24327345-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 Kaczmarski, W et al. (2014) Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). J. Neurosci. Res. 92 162-73 PubMed GONUTS page

[PMID:28386764-5] 5.0 ^5.1 ^5.2 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page

[PMID:15694837-6] 6.0 ^6.1 Bescond, M & Rahmani, Z (2005) Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA alpha-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein. Int. J. Biochem. Cell Biol. 37 775-83 PubMed GONUTS page

[PMID:23415227-7] Wippich, F et al. (2013) Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling. Cell 152 791-805 PubMed GONUTS page

[PMID:28377597-8] 8.0 ^8.1 ^8.2 Yin, X et al. (2017) Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice. Sci Rep 7 619 PubMed GONUTS page

[PMID:20736167-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Li, D et al. (2010) Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions. J. Biol. Chem. 285 35374-85 PubMed GONUTS page

[PMID:9748265-10] 10.0 ^10.1 Becker, W et al. (1998) Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J. Biol. Chem. 273 25893-902 PubMed GONUTS page

[PMID:23665168-11] Soundararajan, M et al. (2013) Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition. Structure 21 986-96 PubMed GONUTS page

[PMID:8769099-12] 12.0 ^12.1 ^12.2 Shindoh, N et al. (1996) Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21. Biochem. Biophys. Res. Commun. 225 92-9 PubMed GONUTS page

[PMID:9070862-13] Song, WJ et al. (1997) The murine Dyrk protein maps to chromosome 16, localizes to the nucleus, and can form multimers. Biochem. Biophys. Res. Commun. 231 640-4 PubMed GONUTS page

[PMID:8975710-14] Song, WJ et al. (1996) Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region". Genomics 38 331-9 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

HUMAN:DYR1A

Contents

Annotations

Notes

References

a

c

d

e

h

i

k

m

n

o

p

r

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools