GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:DUS19
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | DUSP19 (synonyms: DUSP17, LMWDSP3, SKRP1) | |
| Protein Name(s) | Dual specificity protein phosphatase 19
Dual specificity phosphatase TS-DSP1 Low molecular weight dual specificity phosphatase 3 LMW-DSP3 Protein phosphatase SKRP1 Stress-activated protein kinase pathway-regulating phosphatase 1 SAPK pathway-regulating phosphatase 1 | |
| External Links | ||
| UniProt | Q8WTR2 | |
| EMBL | AB063186 AB063187 AB038770 AF486808 AK314078 AC064871 BC035000 BC093958 BC112005 | |
| CCDS | CCDS2289.1 CCDS46469.1 | |
| RefSeq | NP_001135786.1 NP_543152.1 | |
| UniGene | Hs.132237 | |
| PDB | 3S4E | |
| PDBsum | 3S4E | |
| ProteinModelPortal | Q8WTR2 | |
| SMR | Q8WTR2 | |
| BioGrid | 126770 | |
| IntAct | Q8WTR2 | |
| STRING | 9606.ENSP00000346160 | |
| DEPOD | Q8WTR2 | |
| PhosphoSite | Q8WTR2 | |
| DMDM | 29840769 | |
| MaxQB | Q8WTR2 | |
| PaxDb | Q8WTR2 | |
| PRIDE | Q8WTR2 | |
| DNASU | 142679 | |
| Ensembl | ENST00000342619 ENST00000354221 | |
| GeneID | 142679 | |
| KEGG | hsa:142679 | |
| UCSC | uc002upd.3 uc002upe.3 | |
| CTD | 142679 | |
| GeneCards | GC02P183907 | |
| HGNC | HGNC:18894 | |
| HPA | HPA021501 | |
| MIM | 611437 | |
| neXtProt | NX_Q8WTR2 | |
| PharmGKB | PA134895660 | |
| eggNOG | COG2453 | |
| GeneTree | ENSGT00760000118853 | |
| HOGENOM | HOG000233765 | |
| HOVERGEN | HBG051424 | |
| InParanoid | Q8WTR2 | |
| KO | K14165 | |
| OMA | MEQLRTY | |
| OrthoDB | EOG72JWHW | |
| PhylomeDB | Q8WTR2 | |
| TreeFam | TF354211 | |
| SignaLink | Q8WTR2 | |
| GeneWiki | DUSP19 | |
| GenomeRNAi | 142679 | |
| NextBio | 84595 | |
| PRO | PR:Q8WTR2 | |
| Proteomes | UP000005640 | |
| Bgee | Q8WTR2 | |
| CleanEx | HS_DUSP19 | |
| Genevestigator | Q8WTR2 | |
| GO | GO:0005737 GO:0008579 GO:0005078 GO:0031435 GO:0030295 GO:0004860 GO:0004725 GO:0008330 GO:0000188 GO:0007254 GO:0046329 GO:0043508 GO:0006469 GO:0046330 GO:0043507 GO:0043410 GO:0045860 GO:0006470 | |
| Gene3D | 3.90.190.10 | |
| InterPro | IPR020417 IPR000340 IPR020422 IPR024950 IPR029021 IPR000387 | |
| PANTHER | PTHR10159 | |
| Pfam | PF00782 | |
| PRINTS | PR01908 | |
| SMART | SM00195 | |
| SUPFAM | SSF52799 | |
| PROSITE | PS50056 PS50054 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0046330 |
positive regulation of JNK cascade |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046329 |
negative regulation of JNK cascade |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045860 |
positive regulation of protein kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043508 |
negative regulation of JUN kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043507 |
positive regulation of JUN kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043410 |
positive regulation of MAPK cascade |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0004651 |
polynucleotide 5'-phosphatase activity |
ECO:0000314 |
F |
A high activity of acid phosphatase is associated to several diseases (osteoporosis, Alzheimer's, prostate cancer, among others) |
complete | |||||
|
enables |
GO:0031435 |
mitogen-activated protein kinase kinase kinase binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030295 |
protein kinase activator activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005078 |
MAP-kinase scaffold activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004860 |
protein kinase inhibitor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043405 |
regulation of MAP kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1915332 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008579 |
JUN kinase phosphatase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1915332 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1915332 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032147 |
activation of protein kinase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0030295 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008138 |
protein tyrosine/serine/threonine phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016791 |
phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Urquiza, NM et al. (2015) Anti-thyroid and antifungal activities, BSA interaction and acid phosphatase inhibition of methimazole copper(II) complexes. Chem. Biol. Interact. 229 64-72 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
m
n
p
- GO:0035335 ! peptidyl-tyrosine dephosphorylation
- GO:0016791 ! phosphatase activity
- GO:0004721 ! phosphoprotein phosphatase activity
- GO:0004651 ! polynucleotide 5'-phosphatase activity
- GO:0046330 ! positive regulation of JNK cascade
- GO:0043507 ! positive regulation of JUN kinase activity
- GO:0043410 ! positive regulation of MAPK cascade
- GO:0045860 ! positive regulation of protein kinase activity
- Primates
- GO:0006470 ! protein dephosphorylation
- GO:0004860 ! protein kinase inhibitor activity
- GO:0030295 ! protein kinase activator activity
- GO:0004725 ! protein tyrosine phosphatase activity
- GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity
