HUMAN:DRD1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DRD1
Protein Name(s)	D(1A) dopamine receptor Dopamine D1 receptor
External Links
UniProt	P21728
EMBL	X55760 X58987 X55758 S58541 AB065677 AF498961 AK314031 CH471062 BC074978 BC074979 BC096837
CCDS	CCDS4393.1
PIR	S11377
RefSeq	NP_000785.1
UniGene	Hs.2624
PDB	1OZ5
PDBsum	1OZ5
ProteinModelPortal	P21728
SMR	P21728
BioGrid	108146
MINT	MINT-123019
STRING	9606.ENSP00000327652
BindingDB	P21728
ChEMBL	CHEMBL2096905
DrugBank	DB01614 DB01063 DB00543 DB00714 DB01238 DB06216 DB01200 DB00248 DB00477 DB01239 DB00568 DB00363 DB00988 DB01049 DB00696 DB00800 DB00875 DB00623 DB00502 DB04946 DB00458 DB01235 DB00589 DB00408 DB01403 DB00353 DB06148 DB00805 DB00370 DB00334 DB01267 DB01186 DB00850 DB00397 DB01621 DB00413 DB00420 DB01608 DB00777 DB01224 DB00734 DB00268 DB05271 DB01622 DB00679 DB01623 DB00508 DB00726 DB00246 DB01624
GuidetoPHARMACOLOGY	214
iPTMnet	P21728
PhosphoSite	P21728
SwissPalm	P21728
BioMuta	DRD1
DMDM	118228
PaxDb	P21728
PRIDE	P21728
DNASU	1812
Ensembl	ENST00000393752
GeneID	1812
KEGG	hsa:1812
UCSC	uc003mcz.3
CTD	1812
GeneCards	DRD1
HGNC	HGNC:3020
HPA	HPA013393
MIM	126449
neXtProt	NX_P21728
PharmGKB	PA147
eggNOG	KOG3656 ENOG410XRW9
GeneTree	ENSGT00760000118774
HOGENOM	HOG000239242
HOVERGEN	HBG106962
InParanoid	P21728
KO	K04144
OMA	SSLNRMY
OrthoDB	EOG780RMN
PhylomeDB	P21728
TreeFam	TF325181
Reactome	R-HSA-390651 R-HSA-418555
GeneWiki	Dopamine_receptor_D1
GenomeRNAi	1812
NextBio	7385
PRO	PR:P21728
Proteomes	UP000005640
Bgee	P21728
CleanEx	HS_DRD1
Genevisible	P21728
GO	GO:0043679 GO:0005901 GO:0060170 GO:0005829 GO:0043198 GO:0044327 GO:0044326 GO:0005789 GO:0005887 GO:0043025 GO:0031513 GO:0005634 GO:0005886 GO:0035240 GO:0004952 GO:0001588 GO:0008144 GO:0007190 GO:0007191 GO:0007189 GO:0007628 GO:0014002 GO:0001662 GO:0048148 GO:0019722 GO:0071870 GO:0071456 GO:0032869 GO:0021853 GO:0001661 GO:0021542 GO:0042417 GO:0015872 GO:0007187 GO:0046323 GO:0007625 GO:0046959 GO:0007612 GO:0060292 GO:0060291 GO:0042711 GO:0007617 GO:0007613 GO:0030336 GO:0042321 GO:0006469 GO:0019228 GO:0035106 GO:0021769 GO:0030432 GO:0060158 GO:0010579 GO:0030819 GO:0030335 GO:0051482 GO:2000253 GO:1900273 GO:0045838 GO:0043268 GO:0051281 GO:0051968 GO:0060134 GO:0006606 GO:0042053 GO:0051584 GO:0048169 GO:0019229 GO:0014823 GO:0043200 GO:0001975 GO:0036276 GO:0042493 GO:0032355 GO:0045471 GO:0032094 GO:0043278 GO:0035094 GO:0032526 GO:0046960 GO:0035176 GO:0021756 GO:0007416 GO:0001963 GO:0001659 GO:0019226 GO:0042311 GO:0008542
InterPro	IPR001413 IPR000929 IPR000276 IPR017452
Pfam	PF00001
PRINTS	PR00565 PR00242 PR00237
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0043197	dendritic spine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61616	C		Seeded From UniProt	complete
involved_in	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	PMID:17760784^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903351	cellular response to dopamine	PMID:24136195^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24136195^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P0DMM9) has_regulation_target:(UniProtKB:P50225)	Seeded From UniProt	complete
part_of	GO:0097730	non-motile cilium	PMID:20531939^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	PMID:20531939^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071870	cellular response to catecholamine stimulus	PMID:18403039^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	PMID:1282671^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61616	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61616	P		Seeded From UniProt	complete
involved_in	GO:0051584	regulation of dopamine uptake involved in synaptic transmission	PMID:8301582^[6]	ECO:0000305	curator inference used in manual assertion	GO:0001588	P		Seeded From UniProt	complete
involved_in	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	PMID:1282671^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	PMID:7838121^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	PMID:1282671^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043268	positive regulation of potassium ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7LZ75	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61616	P		Seeded From UniProt	complete
involved_in	GO:0042417	dopamine metabolic process	PMID:8301582^[6]	ECO:0000305	curator inference used in manual assertion	GO:0001588	P		Seeded From UniProt	complete
enables	GO:0035240	dopamine binding	PMID:1282671^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	PMID:7838121^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	PMID:1282671^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61616	P		Seeded From UniProt	complete
involved_in	GO:0021853	cerebral cortex GABAergic interneuron migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61616	P		Seeded From UniProt	complete
involved_in	GO:0019226	transmission of nerve impulse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61616	P		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61616	P		Seeded From UniProt	complete
involved_in	GO:0007628	adult walking behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61616	P		Seeded From UniProt	complete
involved_in	GO:0007617	mating behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61616	P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18901	P		Seeded From UniProt	complete
involved_in	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	PMID:18403039^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	PMID:2168520^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	PMID:2144334^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007190	activation of adenylate cyclase activity	PMID:2168520^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PMID:2144334^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:1282671^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:2144334^[9]	ECO:0000305	curator inference used in manual assertion	GO:0001588	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15569306^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	PMID:7838121^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	PMID:1282671^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
Colocalizes with	GO:0005903	brush border	PMID:25825816^[11]	ECO:0000314			C		Figure 4A: Dopamine D1 receptor colocalizes at the brush border of human renal proximal tubule cells.	complete CACAO 12304
enables	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	PMID:2168520^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
Colocalizes with	GO:0005899	insulin receptor complex	PMID:25825816^[11]	ECO:0000314			C		Figure 4C: Dopamine D1 receptor colocalizes with the IR in the perinuclear area in human renal proximal tubule cells at the basal state and increasingly after administration of insulin.	complete CACAO 12305
enables	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	PMID:2144334^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PMID:11500503^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11500503^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0035240	dopamine binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000665343 UniProtKB:P21728 UniProtKB:P21918	F		Seeded From UniProt	complete
involved_in	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99578 PANTHER:PTN000665343 RGD:2523 UniProtKB:P21728 UniProtKB:P21918	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99578 PANTHER:PTN000665343 UniProtKB:P21728 UniProtKB:P21918	C		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000665343 RGD:2523	F		Seeded From UniProt	complete
enables	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94927 MGI:MGI:99578 PANTHER:PTN000665343 RGD:2523 UniProtKB:P21728	F		Seeded From UniProt	complete
involved_in	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	PMID:17194762^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P14416	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:28154160^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004952	dopamine neurotransmitter receptor activity	PMID:1831904^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	C		Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	C		Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	C		Seeded From UniProt	complete
involved_in	GO:0060292	long-term synaptic depression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0046960	sensitization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0046959	habituation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0046323	glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0043987	histone H3-S10 phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	C		Seeded From UniProt	complete
involved_in	GO:0042711	maternal behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0042053	regulation of dopamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0035106	operant conditioning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0030432	peristalsis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0021853	cerebral cortex GABAergic interneuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0021756	striatum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0021542	dentate gyrus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0019228	neuronal action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0019226	transmission of nerve impulse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	C		Seeded From UniProt	complete
involved_in	GO:0015872	dopamine transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0014002	astrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	C		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0008306	associative learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0007631	feeding behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0007628	adult walking behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0007625	grooming behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0007617	mating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0007212	dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0007190	activation of adenylate cyclase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0006936	muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	C		Seeded From UniProt	complete
enables	GO:0004952	dopamine neurotransmitter receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	F		Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0001963	synaptic transmission, dopaminergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0001662	behavioral fear response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0001661	conditioned taste aversion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	P		Seeded From UniProt	complete
enables	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61616 ensembl:ENSMUSP00000021932	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
enables	GO:0004952	dopamine neurotransmitter receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001413	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001413	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	P		Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001413	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR017452	C		Seeded From UniProt	complete
involved_in	GO:0042311	vasodilation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001413	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-744887 Reactome:R-HSA-744886 Reactome:R-HSA-390835 Reactome:R-HSA-379044	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0284	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kou, J & Yoshimura, M (2007) Isoform-specific enhancement of adenylyl cyclase activity by n-alkanols. Alcohol. Clin. Exp. Res. 31 1467-72 PubMed GONUTS page
↑ ^2.0 ^2.1 Sidharthan, NP et al. (2013) Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling. J. Biol. Chem. 288 34364-74 PubMed GONUTS page
↑ ^3.0 ^3.1 Marley, A & von Zastrow, M (2010) DISC1 regulates primary cilia that display specific dopamine receptors. PLoS ONE 5 e10902 PubMed GONUTS page
↑ ^4.0 ^4.1 Sakihama, T et al. (2008) Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system. J. Biotechnol. 135 28-33 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Liu, YF et al. (1992) Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A. Mol. Endocrinol. 6 1815-24 PubMed GONUTS page
↑ ^6.0 ^6.1 Freedman, SB et al. (1994) Expression and pharmacological characterization of the human D3 dopamine receptor. J. Pharmacol. Exp. Ther. 268 417-26 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Lin, CW et al. (1995) Characterization of cloned human dopamine D1 receptor-mediated calcium release in 293 cells. Mol. Pharmacol. 47 131-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Zhou, QY et al. (1990) Cloning and expression of human and rat D1 dopamine receptors. Nature 347 76-80 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Dearry, A et al. (1990) Molecular cloning and expression of the gene for a human D1 dopamine receptor. Nature 347 72-6 PubMed GONUTS page
↑ Yu, P et al. (2004) D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int. 66 2167-80 PubMed GONUTS page
↑ ^11.0 ^11.1 Li, F et al. (2015) Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells. Endocrinology 156 2211-21 PubMed GONUTS page
↑ ^12.0 ^12.1 Wang, Q et al. (2001) Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase. J. Biol. Chem. 276 39386-93 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Rashid, AJ et al. (2007) D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc. Natl. Acad. Sci. U.S.A. 104 654-9 PubMed GONUTS page
↑ Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page
↑ Tiberi, M et al. (1991) Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor. Proc. Natl. Acad. Sci. U.S.A. 88 7491-5 PubMed GONUTS page

[PMID:17760784-1] Kou, J & Yoshimura, M (2007) Isoform-specific enhancement of adenylyl cyclase activity by n-alkanols. Alcohol. Clin. Exp. Res. 31 1467-72 PubMed GONUTS page

[PMID:24136195-2] 2.0 ^2.1 Sidharthan, NP et al. (2013) Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling. J. Biol. Chem. 288 34364-74 PubMed GONUTS page

[PMID:20531939-3] 3.0 ^3.1 Marley, A & von Zastrow, M (2010) DISC1 regulates primary cilia that display specific dopamine receptors. PLoS ONE 5 e10902 PubMed GONUTS page

[PMID:18403039-4] 4.0 ^4.1 Sakihama, T et al. (2008) Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system. J. Biotechnol. 135 28-33 PubMed GONUTS page

[PMID:1282671-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Liu, YF et al. (1992) Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A. Mol. Endocrinol. 6 1815-24 PubMed GONUTS page

[PMID:8301582-6] 6.0 ^6.1 Freedman, SB et al. (1994) Expression and pharmacological characterization of the human D3 dopamine receptor. J. Pharmacol. Exp. Ther. 268 417-26 PubMed GONUTS page

[PMID:7838121-7] 7.0 ^7.1 ^7.2 Lin, CW et al. (1995) Characterization of cloned human dopamine D1 receptor-mediated calcium release in 293 cells. Mol. Pharmacol. 47 131-9 PubMed GONUTS page

[PMID:2168520-8] 8.0 ^8.1 ^8.2 Zhou, QY et al. (1990) Cloning and expression of human and rat D1 dopamine receptors. Nature 347 76-80 PubMed GONUTS page

[PMID:2144334-9] 9.0 ^9.1 ^9.2 ^9.3 Dearry, A et al. (1990) Molecular cloning and expression of the gene for a human D1 dopamine receptor. Nature 347 72-6 PubMed GONUTS page

[PMID:15569306-10] Yu, P et al. (2004) D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int. 66 2167-80 PubMed GONUTS page

[PMID:25825816-11] 11.0 ^11.1 Li, F et al. (2015) Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells. Endocrinology 156 2211-21 PubMed GONUTS page

[PMID:11500503-12] 12.0 ^12.1 Wang, Q et al. (2001) Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase. J. Biol. Chem. 276 39386-93 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17194762-14] Rashid, AJ et al. (2007) D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc. Natl. Acad. Sci. U.S.A. 104 654-9 PubMed GONUTS page

[PMID:28154160-15] Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page

[PMID:1831904-16] Tiberi, M et al. (1991) Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor. Proc. Natl. Acad. Sci. U.S.A. 88 7491-5 PubMed GONUTS page

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