HUMAN:DNMT1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DNMT1 (synonyms: AIM, CXXC9, DNMT)
Protein Name(s)	DNA (cytosine-5)-methyltransferase 1 Dnmt1 CXXC-type zinc finger protein 9 DNA methyltransferase HsaI DNA MTase HsaI M.HsaI MCMT
External Links
UniProt	P26358
EMBL	X63692 AF180682 AC010077 AC011511 AC020931 BC126227 BC144093 AH008119
CCDS	CCDS12228.1 CCDS45958.1
PIR	S22610
RefSeq	NP_001124295.1 NP_001370.1
UniGene	Hs.202672
PDB	3EPZ 3PTA 3SWR
PDBsum	3EPZ 3PTA 3SWR
ProteinModelPortal	P26358
SMR	P26358
BioGrid	108123
DIP	DIP-39693N
IntAct	P26358
MINT	MINT-232346
STRING	9606.ENSP00000352516
BindingDB	P26358
ChEMBL	CHEMBL1993
DrugBank	DB00928 DB01262 DB01099 DB01035
REBASE	1161
PhosphoSite	P26358
DMDM	12231019
MaxQB	P26358
PaxDb	P26358
PRIDE	P26358
Ensembl	ENST00000340748 ENST00000359526 ENST00000540357
GeneID	1786
KEGG	hsa:1786
UCSC	uc002mng.3 uc010xlc.2
CTD	1786
GeneCards	GC19M010244
GeneReviews	DNMT1
HGNC	HGNC:2976
HPA	CAB005876 HPA002694
MIM	126375 604121 614116
neXtProt	NX_P26358
Orphanet	314404
PharmGKB	PA27443
eggNOG	COG0270
GeneTree	ENSGT00390000005100
HOGENOM	HOG000082497
HOVERGEN	HBG051384
InParanoid	P26358
KO	K00558
OMA	CPNLAVK
OrthoDB	EOG77WWBH
PhylomeDB	P26358
TreeFam	TF328926
BRENDA	2.1.1.37
Reactome	REACT_200808 REACT_200856 REACT_267652
ChiTaRS	DNMT1
EvolutionaryTrace	P26358
GeneWiki	DNMT1
GenomeRNAi	1786
NextBio	7267
PRO	PR:P26358
Proteomes	UP000005640
Bgee	P26358
CleanEx	HS_DNMT1
ExpressionAtlas	P26358
Genevestigator	P26358
GO	GO:0005634 GO:0005721 GO:0005657 GO:0003682 GO:0003886 GO:0003677 GO:0009008 GO:0008327 GO:0003723 GO:0008270 GO:0071230 GO:0016568 GO:0006306 GO:0016458 GO:0010216 GO:0051573 GO:0000122 GO:0010628 GO:0051571 GO:0042127 GO:0006351
Gene3D	3.40.50.150
InterPro	IPR001025 IPR018117 IPR001525 IPR022702 IPR010506 IPR017198 IPR029063 IPR002857
Pfam	PF01426 PF06464 PF12047 PF02008
PIRSF	PIRSF037404
PRINTS	PR00105
SMART	SM00439
SUPFAM	SSF53335
PROSITE	PS51038 PS00094 PS00095 PS51679 PS51058

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0042127	regulation of cell proliferation	PMID:21572997^[1]	ECO:0000314			P		FIg. 2B shows that inhibition of DNMTs decreases the proliferation rate in a dose-dependent manner. Fig. 2E shows that inhibition of DNMTs arrests most cells in the G1 phase.	complete CACAO 10766
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:A1A5S2 UniProtKB:P13864 UniProtKB:P55200	F		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:27021683^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000112096) occurs_in:(CL:0002591)	Seeded From UniProt	complete
involved_in	GO:1905931	negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching	PMID:27021683^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456) occurs_in:(CL:0002591)	Seeded From UniProt	complete
involved_in	GO:1905460	negative regulation of vascular associated smooth muscle cell apoptotic process	PMID:27021683^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456) occurs_in:(CL:0002591)	Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	PMID:27021683^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_division_of:(CL:0002591) part_of:(GO:0071456)	Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	PMID:24623306^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090309	positive regulation of methylation-dependent chromatin silencing	PMID:24623306^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:24623306^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16791210^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051573	negative regulation of histone H3-K9 methylation	PMID:18413740^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051571	positive regulation of histone H3-K4 methylation	PMID:18413740^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:18413740^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010216	maintenance of DNA methylation	PMID:21745816^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010216	maintenance of DNA methylation	PMID:18754681^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0009008	DNA-methyltransferase activity	PMID:18754681^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	PMID:21745816^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:18754681^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010424	DNA methylation on cytosine within a CG sequence	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000066774 RGD:620979 TAIR:locus:2155959	P		Seeded From UniProt	complete
involved_in	GO:0010216	maintenance of DNA methylation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94912 PANTHER:PTN000066774 RGD:620979 TAIR:locus:2155959 UniProtKB:C0SQ89 UniProtKB:P26358	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94912 PANTHER:PTN000066775 RGD:620979	C		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94912 PANTHER:PTN000066774 RGD:620979 TAIR:locus:2117104 TAIR:locus:2205015 UniProtKB:P26358	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94912 PANTHER:PTN000066774 UniProtKB:P26358	F		Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	P		Seeded From UniProt	complete
involved_in	GO:0043045	DNA methylation involved in embryo development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	P		Seeded From UniProt	complete
involved_in	GO:0032776	DNA methylation on cytosine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	P		Seeded From UniProt	complete
involved_in	GO:0016458	gene silencing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	P		Seeded From UniProt	complete
involved_in	GO:0010216	maintenance of DNA methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	P		Seeded From UniProt	complete
enables	GO:0008327	methyl-CpG binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	F		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	F		Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	P		Seeded From UniProt	complete
part_of	GO:0005721	pericentric heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	C		Seeded From UniProt	complete
part_of	GO:0005657	replication fork	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	C		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13864 ensembl:ENSMUSP00000004202	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002857	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001025	F		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017198	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017198	C		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001525	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002857	F		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017198	P		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.37	F		Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	PMID:10888872^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8940105^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	PMID:8940105^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10888872^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	Reactome:R-HSA-212300	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0009008	DNA-methyltransferase activity	Reactome:R-HSA-212269	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-4655431 Reactome:R-HSA-212269 Reactome:R-HSA-212222	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ So, AY et al. (2011) DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs. PLoS ONE 6 e19503 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Zhang, Y & Xu, J (2016) MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression. Biochem. Biophys. Res. Commun. 473 342-348 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Serra, RW et al. (2014) A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 3 e02313 PubMed GONUTS page
↑ Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Sun, L et al. (2008) DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. Cancer Res. 68 2726-35 PubMed GONUTS page
↑ ^6.0 ^6.1 Felle, M et al. (2011) The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. Nucleic Acids Res. 39 8355-65 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Pradhan, M et al. (2008) CXXC domain of human DNMT1 is essential for enzymatic activity. Biochemistry 47 10000-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 Rountree, MR et al. (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat. Genet. 25 269-77 PubMed GONUTS page
↑ ^10.0 ^10.1 Yoder, JA et al. (1996) New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase. J. Biol. Chem. 271 31092-7 PubMed GONUTS page

[PMID:21572997-1] So, AY et al. (2011) DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs. PLoS ONE 6 e19503 PubMed GONUTS page

[PMID:27021683-2] 2.0 ^2.1 ^2.2 ^2.3 Zhang, Y & Xu, J (2016) MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression. Biochem. Biophys. Res. Commun. 473 342-348 PubMed GONUTS page

[PMID:24623306-3] 3.0 ^3.1 ^3.2 Serra, RW et al. (2014) A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 3 e02313 PubMed GONUTS page

[PMID:16791210-4] Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page

[PMID:18413740-5] 5.0 ^5.1 ^5.2 Sun, L et al. (2008) DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. Cancer Res. 68 2726-35 PubMed GONUTS page

[PMID:21745816-6] 6.0 ^6.1 Felle, M et al. (2011) The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. Nucleic Acids Res. 39 8355-65 PubMed GONUTS page

[PMID:18754681-7] 7.0 ^7.1 ^7.2 Pradhan, M et al. (2008) CXXC domain of human DNMT1 is essential for enzymatic activity. Biochemistry 47 10000-9 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10888872-9] 9.0 ^9.1 Rountree, MR et al. (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat. Genet. 25 269-77 PubMed GONUTS page

[PMID:8940105-10] 10.0 ^10.1 Yoder, JA et al. (1996) New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase. J. Biol. Chem. 271 31092-7 PubMed GONUTS page

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HUMAN:DNMT1

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Annotations

Notes

References

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