HUMAN:DNM3A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DNMT3A
Protein Name(s)	DNA (cytosine-5)-methyltransferase 3A Dnmt3a DNA methyltransferase HsaIIIA DNA MTase HsaIIIA M.HsaIIIA
External Links
UniProt	Q9Y6K1
EMBL	AF067972 AF480163 AF331856 AC012074 CH471053 BC032392 BC043617 BC051864
CCDS	CCDS1718.2 CCDS33157.1 CCDS46232.1
RefSeq	NP_072046.2 NP_715640.2 NP_783328.1 NP_783329.1 XP_005264232.1 XP_005264233.1 XP_005264234.1
UniGene	Hs.515840
PDB	2QRV 3A1A 3A1B 3LLR 3SVM 4U7P 4U7T
PDBsum	2QRV 3A1A 3A1B 3LLR 3SVM 4U7P 4U7T
ProteinModelPortal	Q9Y6K1
SMR	Q9Y6K1
BioGrid	108125
DIP	DIP-38004N
IntAct	Q9Y6K1
STRING	9606.ENSP00000264709
BindingDB	Q9Y6K1
ChEMBL	CHEMBL3137291
REBASE	4119
PhosphoSite	Q9Y6K1
DMDM	166215081
MaxQB	Q9Y6K1
PaxDb	Q9Y6K1
PRIDE	Q9Y6K1
DNASU	1788
Ensembl	ENST00000264709 ENST00000321117 ENST00000380746 ENST00000402667 ENST00000406659
GeneID	1788
KEGG	hsa:1788
UCSC	uc002rgc.4 uc002rgf.3
CTD	1788
GeneCards	GC02M025455
HGNC	HGNC:2978
HPA	CAB009469 HPA026588
MIM	602769 615879
neXtProt	NX_Q9Y6K1
Orphanet	404443
PharmGKB	PA27445
eggNOG	NOG70699
GeneTree	ENSGT00390000008341
HOGENOM	HOG000230875
HOVERGEN	HBG051381
InParanoid	Q9Y6K1
KO	K17398
OMA	FVGGMCQ
OrthoDB	EOG7MWGW6
PhylomeDB	Q9Y6K1
TreeFam	TF329039
BRENDA	2.1.1.37
Reactome	REACT_200808 REACT_228108 REACT_267652
ChiTaRS	DNMT3A
EvolutionaryTrace	Q9Y6K1
GenomeRNAi	1788
NextBio	7279
PRO	PR:Q9Y6K1
Proteomes	UP000005640
Bgee	Q9Y6K1
CleanEx	HS_DNMT3A
ExpressionAtlas	Q9Y6K1
Genevestigator	Q9Y6K1
GO	GO:0000775 GO:0005737 GO:0000791 GO:0005720 GO:0016363 GO:0005654 GO:0005634 GO:0003682 GO:0003886 GO:0051718 GO:0003677 GO:0042802 GO:0046872 GO:0045322 GO:0090116 GO:0071230 GO:0006306 GO:0043045 GO:0043046 GO:0010424 GO:0044027 GO:0006346 GO:0000122 GO:0006349 GO:0046498 GO:0046499 GO:0007283
Gene3D	3.40.50.150
InterPro	IPR025766 IPR018117 IPR001525 IPR000313 IPR029063
Pfam	PF00855
SMART	SM00293
SUPFAM	SSF53335
PROSITE	PS51533 PS00094 PS50812 PS51679

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0042127	regulation of cell proliferation	PMID:21572997^[1]	ECO:0000314			P		FIg. 2B shows that inhibition of DNMTs decreases the proliferation rate in a dose-dependent manner. Fig. 2E shows that inhibition of DNMTs arrests most cells in the G1 phase.	complete CACAO 10767
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19786833^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000110092)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:19786833^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000110092)	Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	PMID:19786833^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(ENSEMBL:ENSG00000110092) occurs_at:(SO:0005836)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19786833^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P17679	F		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	PMID:19786833^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0000122) regulates_transcription_of:(ENSEMBL:ENSG00000110092)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:23042785^[3]	ECO:0000305	curator inference used in manual assertion	GO:0000978,GO:0006306	P	regulates_transcription_of:(ENSEMBL:ENSG00000076242)\|regulates_transcription_of:(ENSEMBL:ENSG00000112246)\|regulates_transcription_of:(ENSEMBL:ENSG00000092969)	Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	PMID:23042785^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(ENSEMBL:ENSG00000076242) occurs_at:(SO:0001952)\|has_direct_input(ENSEMBL:ENSG00000112246) occurs_at:(SO:0001952)\|has_direct_input(ENSEMBL:ENSG00000092969) occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:23042785^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000076242)\|has_direct_input:(ENSEMBL:ENSG00000112246)\|has_direct_input:(ENSEMBL:ENSG00000092969)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25743254^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	PMID:12138111^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	PMID:12138111^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12138111^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12138111^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	PMID:12138111^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12138111^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000791	euchromatin	PMID:12138111^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24656771^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y6K1	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003886	P		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003886	P		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003886	P		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003886	P		Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	P		Seeded From UniProt	complete
involved_in	GO:0043046	DNA methylation involved in gamete generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	P		Seeded From UniProt	complete
involved_in	GO:0043045	DNA methylation involved in embryo development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	P		Seeded From UniProt	complete
involved_in	GO:0006349	regulation of gene expression by genetic imprinting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	P		Seeded From UniProt	complete
involved_in	GO:0006346	methylation-dependent chromatin silencing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	P		Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	C		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	C		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	F		Seeded From UniProt	complete
part_of	GO:0001741	XY body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	C		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	C		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88508 ensembl:ENSMUSP00000020991	P		Seeded From UniProt	complete
involved_in	GO:0097284	hepatocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0071361	cellular response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0032776	DNA methylation on cytosine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0010288	response to lead ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	F		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030487	P		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001525	F		Seeded From UniProt	complete
enables	GO:0009008	DNA-methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030487	F		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030487	P		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.37	F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:19786833^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006349	regulation of gene expression by genetic imprinting	PMID:12138111^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	Reactome:R-HSA-212300	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0009008	DNA-methyltransferase activity	Reactome:R-HSA-212269	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5212679 Reactome:R-HSA-212269 Reactome:R-HSA-212222	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ So, AY et al. (2011) DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs. PLoS ONE 6 e19503 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Hervouet, E et al. (2009) Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics 4 487-99 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Szemes, M et al. (2013) Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A. Hum. Mol. Genet. 22 74-83 PubMed GONUTS page
↑ Štalekar, M et al. (2015) Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport. Neuroscience 293 157-70 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Chen, T et al. (2002) A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. J. Biol. Chem. 277 38746-54 PubMed GONUTS page
↑ Russler-Germain, DA et al. (2014) The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. Cancer Cell 25 442-54 PubMed GONUTS page

[PMID:21572997-1] So, AY et al. (2011) DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs. PLoS ONE 6 e19503 PubMed GONUTS page

[PMID:19786833-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Hervouet, E et al. (2009) Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics 4 487-99 PubMed GONUTS page

[PMID:23042785-3] 3.0 ^3.1 ^3.2 Szemes, M et al. (2013) Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A. Hum. Mol. Genet. 22 74-83 PubMed GONUTS page

[PMID:25743254-4] Štalekar, M et al. (2015) Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport. Neuroscience 293 157-70 PubMed GONUTS page

[PMID:12138111-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Chen, T et al. (2002) A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. J. Biol. Chem. 277 38746-54 PubMed GONUTS page

[PMID:24656771-6] Russler-Germain, DA et al. (2014) The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. Cancer Cell 25 442-54 PubMed GONUTS page

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HUMAN:DNM3A

Contents

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