HUMAN:DNM1L

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DNM1L (synonyms: DLP1, DRP1)
Protein Name(s)	Dynamin-1-like protein Dnm1p/Vps1p-like protein DVLP Dynamin family member proline-rich carboxyl-terminal domain less Dymple Dynamin-like protein Dynamin-like protein 4 Dynamin-like protein IV HdynIV Dynamin-related protein 1
External Links
UniProt	O00429
EMBL	AB006965 AF061795 AF000430 AF151685 AK299926 AK291094 AK294533 AB209070 AC084824 AC087588 BC024590
CCDS	CCDS61095.1 CCDS61096.1 CCDS61098.1 CCDS61099.1 CCDS8728.1 CCDS8729.1 CCDS8730.1
PIR	JC5695
RefSeq	NP_001265392.1 NP_001265393.1 NP_001265394.1 NP_001265395.1 NP_001317309.1 NP_005681.2 NP_036192.2 NP_036193.2
UniGene	Hs.556296
PDB	3W6N 3W6O 3W6P 4BEJ 4H1U 4H1V
PDBsum	3W6N 3W6O 3W6P 4BEJ 4H1U 4H1V
ProteinModelPortal	O00429
SMR	O00429
BioGrid	115370
DIP	DIP-42704N
IntAct	O00429
MINT	MINT-1394198
STRING	9606.ENSP00000450399
iPTMnet	O00429
PhosphoSitePlus	O00429
SwissPalm	O00429
EPD	O00429
MaxQB	O00429
PaxDb	O00429
PeptideAtlas	O00429
PRIDE	O00429
DNASU	10059
Ensembl	ENST00000266481 ENST00000381000 ENST00000414834 ENST00000452533 ENST00000547312 ENST00000549701 ENST00000553257
GeneID	10059
KEGG	hsa:10059
UCSC	uc001rld.4
CTD	10059
DisGeNET	10059
GeneCards	DNM1L
H-InvDB	HIX0010537
HGNC	HGNC:2973
HPA	CAB009952 HPA039324
MalaCards	DNM1L
MIM	603850 614388
neXtProt	NX_O00429
OpenTargets	ENSG00000087470
Orphanet	330050
PharmGKB	PA27441
eggNOG	KOG0446 COG0699
GeneTree	ENSGT00760000119213
HOGENOM	HOG000161068
HOVERGEN	HBG107833
InParanoid	O00429
KO	K17065
OMA	GQEPTTG
OrthoDB	EOG091G02TQ
PhylomeDB	O00429
TreeFam	TF352031
Reactome	[www.reactome.org/content/detail/R-HSA-75153 R-HSA-75153]
SIGNOR	O00429
ChiTaRS	DNM1L
GeneWiki	DNM1L
GenomeRNAi	10059
PMAP-CutDB	O00429
PRO	PR:O00429
Proteomes	UP000005640
Bgee	ENSG00000087470
CleanEx	HS_DNM1L
ExpressionAtlas	O00429
Genevisible	O00429
GO	GO:0005903 GO:0030054 GO:0005905 GO:0005737 GO:0005829 GO:0005783 GO:0005789 GO:0005794 GO:0000139 GO:0043231 GO:0016020 GO:0005874 GO:0015630 GO:0005741 GO:0005739 GO:0048471 GO:0005777 GO:0043234 GO:0030672 GO:0005525 GO:0030742 GO:0005096 GO:0003924 GO:0042802 GO:0008289 GO:0008017 GO:0042803 GO:0017137 GO:0031625 GO:0090650 GO:1904579 GO:0003374 GO:0006897 GO:0097194 GO:0060047 GO:0048312 GO:0061025 GO:0000266 GO:0043653 GO:0090149 GO:0070584 GO:0007005 GO:0070266 GO:0016559 GO:0043065 GO:0061003 GO:2001244 GO:0090141 GO:0050714 GO:0090200 GO:0051289 GO:0070585 GO:0051259 GO:1903578 GO:0010821 GO:1903146 GO:1900063 GO:0032459 GO:0001836 GO:1905395 GO:1990910
InterPro	IPR030556 IPR000375 IPR001401 IPR019762 IPR022812 IPR030381 IPR003130 IPR020850 IPR027417
PANTHER	PTHR11566 PTHR11566:SF127
Pfam	PF01031 PF00350 PF02212
PRINTS	PR00195
SMART	SM00053 SM00302
SUPFAM	SSF52540
PROSITE	PS00410 PS51718 PS51388

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0090149	mitochondrial membrane fission	PMID:27301544^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090149	mitochondrial membrane fission	PMID:27328748^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:28969390^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:28969390^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:29307555^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:26618722^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0090023	positive regulation of neutrophil chemotaxis	PMID:28388446^[6]	ECO:0000315			P		Suppression of Drp1 revealed inhibition of neutrophil polarization and chemotaxis; thus, as seen in Fig. 6.Thus, Drp1 is needed for neutrophil chemotaxis. Dynamin-1-like protein (DNM1L_HUMAN) Homo sapiens (Human)	complete CACAO 12719
part_of	GO:0005783	endoplasmic reticulum	PMID:9472031^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001608)	Seeded From UniProt	complete
colocalizes_with	GO:0005874	microtubule	PMID:9472031^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001608) exists_during:(GO:0047496)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:9472031^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001608)	Seeded From UniProt	complete
NOT\|part_of	GO:0005783	endoplasmic reticulum	PMID:11514614^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:11514614^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11514614^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|involved_in	GO:0007029	endoplasmic reticulum organization	PMID:11514614^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048312	intracellular distribution of mitochondria	PMID:11514614^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	PMID:11514614^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:26122121^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030742	GTP-dependent protein binding	PMID:25767741^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:O14966)\|has_direct_input:(UniProtKB:P57729)\|has_direct_input:(UniProtKB:Q13637)	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:25767741^[10]	ECO:0000305	curator inference used in manual assertion	GO:0017137,GO:0030742	F	regulates_activity_of:(UniProtKB:O14966)\|regulates_activity_of:(UniProtKB:P57729)\|regulates_activity_of:(UniProtKB:Q13637)	Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	PMID:25767741^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:O14966)\|has_direct_input:(UniProtKB:P57729)\|has_direct_input:(UniProtKB:Q13637)	Seeded From UniProt	complete
colocalizes_with	GO:0099073	mitochondrion-derived vesicle	PMID:26618722^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903146	regulation of autophagy of mitochondrion	PMID:19279012^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
involved_in	GO:0090141	positive regulation of mitochondrial fission	PMID:19279012^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:27145208^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:27145208^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:27145208^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:26992161^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043653	mitochondrial fragmentation involved in apoptotic process	PMID:12499352^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	PMID:20850011^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900063	regulation of peroxisome organization	PMID:18353969^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMID:21149567^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090149	mitochondrial membrane fission	PMID:11514614^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070266	necroptotic process	PMID:22265414^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061025	membrane fusion	PMID:20850011^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	PMID:18353969^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	PMID:9570752^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:9570752^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043653	mitochondrial fragmentation involved in apoptotic process	PMID:18353969^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043653	mitochondrial fragmentation involved in apoptotic process	PMID:21149567^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17408615^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:20850011^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:23530241^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:22265414^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032459	regulation of protein oligomerization	PMID:20850011^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(UniProtKB:Q07812)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:19407830^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q969V5	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:16874301^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NX47	F		Seeded From UniProt	complete
involved_in	GO:0016559	peroxisome fission	PMID:23921378^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016559	peroxisome fission	PMID:18353969^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016559	peroxisome fission	PMID:12618434^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	PMID:18353969^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	PMID:21149567^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:23921378^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22265414^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:20688057^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:23921378^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:12618434^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:21149567^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:23921378^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:23530241^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:22265414^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12618434^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21149567^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:23530241^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:22265414^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	PMID:23530241^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	PMID:11514614^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	PMID:20850011^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:23921378^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:23530241^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903146	regulation of autophagy of mitochondrion	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002480309 UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0061025	membrane fusion	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170085 UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0048312	intracellular distribution of mitochondria	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002480309 RGD:620416 UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0043653	mitochondrial fragmentation involved in apoptotic process	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002480309 RGD:620416 UniProtKB:O00429	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170085 RGD:620416	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170013 TAIR:locus:2006777 TAIR:locus:2012763 UniProtKB:Q8S944	C		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1921256 PANTHER:PTN002480309 UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0008637	apoptotic mitochondrial changes	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002480309 WB:WBGene00001093	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003392 PANTHER:PTN000170013	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003392 MGI:MGI:1921256 PANTHER:PTN000170013 PomBase:SPBC12C2.08 RGD:2513 RGD:628821 RGD:71096 RGD:727949 TAIR:locus:2006777 UniProtKB:K7GKN2 UniProtKB:O00429 UniProtKB:P20591 UniProtKB:P27594 UniProtKB:P79135 UniProtKB:Q8IHR4 dictyBase:DDB_G0277849 dictyBase:DDB_G0277851	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170013 RGD:2513 RGD:727949 SGD:S000001709 SGD:S000003924 UniProtKB:K7GKN2 UniProtKB:O00429 UniProtKB:O60313 UniProtKB:P27594 UniProtKB:P42697 UniProtKB:Q8S944 WB:WBGene00001130 dictyBase:DDB_G0277849	F		Seeded From UniProt	complete
involved_in	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170085 UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026479 MGI:MGI:1921256 PANTHER:PTN000902162 SGD:S000003924 TAIR:locus:2006777 UniProtKB:O00429 UniProtKB:Q8LFT2 UniProtKB:Q8S944 WB:WBGene00001093	P		Seeded From UniProt	complete
involved_in	GO:0070584	mitochondrion morphogenesis	PMID:21149567^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:24599962^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:23349293^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23349293^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:23349293^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:2000302	positive regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:1990910	response to hypobaric hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:1905395	response to flavonoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:1904579	cellular response to thapsigargin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
part_of	GO:0099503	secretory vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
part_of	GO:0098835	presynaptic endocytic zone membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
involved_in	GO:0090650	cellular response to oxygen-glucose deprivation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:0090141	positive regulation of mitochondrial fission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:0071396	cellular response to lipid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:0070584	mitochondrion morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:0061003	positive regulation of dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
enables	GO:0051433	BH2 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	F		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
involved_in	GO:0048312	intracellular distribution of mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	F		Seeded From UniProt	complete
involved_in	GO:0043653	mitochondrial fragmentation involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
involved_in	GO:0036466	synaptic vesicle recycling via endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	F		Seeded From UniProt	complete
involved_in	GO:0010637	negative regulation of mitochondrial fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
involved_in	GO:1904666	regulation of ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	P		Seeded From UniProt	complete
involved_in	GO:1903578	regulation of ATP metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	P		Seeded From UniProt	complete
involved_in	GO:1900063	regulation of peroxisome organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	P		Seeded From UniProt	complete
involved_in	GO:0070585	protein localization to mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	P		Seeded From UniProt	complete
involved_in	GO:0070266	necroptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	P		Seeded From UniProt	complete
involved_in	GO:0060047	heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	F		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	P		Seeded From UniProt	complete
part_of	GO:0005903	brush border	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	C		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K1M6 ensembl:ENSMUSP00000155155	P		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030556	P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001401 InterPro:IPR003130 InterPro:IPR030556	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000375 InterPro:IPR001401 InterPro:IPR003130 InterPro:IPR030381	F		Seeded From UniProt	complete
involved_in	GO:0016559	peroxisome fission	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030556	P		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:21525035^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:29899447^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O00429-3	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23584531^[33]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O00429-3	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20850011^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O00429-4	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:25767741^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090141	positive regulation of mitochondrial fission	PMID:20436456^[34]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097194	execution phase of apoptosis	Reactome:R-HSA-75153	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-351948	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	Reactome:R-HSA-351948	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0576 UniProtKB-SubCell:SL-0204	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
involved_in	GO:0012501	programmed cell death	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1210	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0260	C		Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0147	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zaha, K et al. (2016) DNM1L-related encephalopathy in infancy with Leigh syndrome-like phenotype and suppression-burst. Clin. Genet. 90 472-474 PubMed GONUTS page
↑ Nasca, A et al. (2016) Biallelic Mutations in DNM1L are Associated with a Slowly Progressive Infantile Encephalopathy. Hum. Mutat. 37 898-903 PubMed GONUTS page
↑ ^3.0 ^3.1 Gerber, S et al. (2017) Mutations in DNM1L, as in OPA1, result in dominant optic atrophy despite opposite effects on mitochondrial fusion and fission. Brain 140 2586-2596 PubMed GONUTS page
↑ Anding, AL et al. (2018) Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance. Curr. Biol. 28 287-295.e6 PubMed GONUTS page
↑ ^5.0 ^5.1 Wang, W et al. (2016) Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes. Nat. Med. 22 54-63 PubMed GONUTS page
↑ Zheng, X et al. (2017) Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis. Mol. Immunol. 87 23-32 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Yoon, Y et al. (1998) A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells. J. Cell Biol. 140 779-93 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Smirnova, E et al. (2001) Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol. Biol. Cell 12 2245-56 PubMed GONUTS page
↑ Shahni, R et al. (2015) Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission. Brain 138 2834-46 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Ortiz-Sandoval, CG et al. () Interaction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteins. Cell Logist 4 e986399 PubMed GONUTS page
↑ ^11.0 ^11.1 Dagda, RK et al. (2009) Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J. Biol. Chem. 284 13843-55 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Fahrner, JA et al. (2016) A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy. Am. J. Med. Genet. A 170 2002-11 PubMed GONUTS page
↑ Sheffer, R et al. (2016) Postnatal microcephaly and pain insensitivity due to a de novo heterozygous DNM1L mutation causing impaired mitochondrial fission and function. Am. J. Med. Genet. A 170 1603-7 PubMed GONUTS page
↑ Karbowski, M et al. (2002) Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J. Cell Biol. 159 931-8 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Montessuit, S et al. (2010) Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell 142 889-901 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Gandre-Babbe, S & van der Bliek, AM (2008) The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol. Biol. Cell 19 2402-12 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 Otera, H et al. (2010) Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J. Cell Biol. 191 1141-58 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Wang, Z et al. (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148 228-43 PubMed GONUTS page
↑ ^20.0 ^20.1 Imoto, M et al. (1998) Identification and functional characterization of a novel human protein highly related to the yeast dynamin-like GTPase Vps1p. J. Cell. Sci. 111 ( Pt 10) 1341-9 PubMed GONUTS page
↑ Kobayashi, S et al. (2007) Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis. Exp. Cell Res. 313 1675-86 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 Koirala, S et al. (2013) Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc. Natl. Acad. Sci. U.S.A. 110 E1342-51 PubMed GONUTS page
↑ Braschi, E et al. (2009) MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. EMBO Rep. 10 748-54 PubMed GONUTS page
↑ Yonashiro, R et al. (2006) A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J. 25 3618-26 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 ^25.4 Palmer, CS et al. (2013) Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. J. Biol. Chem. 288 27584-93 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Li, X & Gould, SJ (2003) The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11. J. Biol. Chem. 278 17012-20 PubMed GONUTS page
↑ Bonekamp, NA et al. (2010) Dynamin-like protein 1 at the Golgi complex: a novel component of the sorting/targeting machinery en route to the plasma membrane. Exp. Cell Res. 316 3454-67 PubMed GONUTS page
↑ ^28.00 ^28.01 ^28.02 ^28.03 ^28.04 ^28.05 ^28.06 ^28.07 ^28.08 ^28.09 ^28.10 ^28.11 ^28.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Baba, T et al. (2014) Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics. J. Biol. Chem. 289 11497-511 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Korobova, F et al. (2013) An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Science 339 464-7 PubMed GONUTS page
↑ Bharti, P et al. (2011) PEX14 is required for microtubule-based peroxisome motility in human cells. J. Cell. Sci. 124 1759-68 PubMed GONUTS page
↑ Kalia, R et al. (2018) Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature 558 401-405 PubMed GONUTS page
↑ Fröhlich, C et al. (2013) Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein. EMBO J. 32 1280-92 PubMed GONUTS page
↑ Landes, T et al. (2010) The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms. EMBO Rep. 11 459-65 PubMed GONUTS page

[PMID:27301544-1] Zaha, K et al. (2016) DNM1L-related encephalopathy in infancy with Leigh syndrome-like phenotype and suppression-burst. Clin. Genet. 90 472-474 PubMed GONUTS page

[PMID:27328748-2] Nasca, A et al. (2016) Biallelic Mutations in DNM1L are Associated with a Slowly Progressive Infantile Encephalopathy. Hum. Mutat. 37 898-903 PubMed GONUTS page

[PMID:28969390-3] 3.0 ^3.1 Gerber, S et al. (2017) Mutations in DNM1L, as in OPA1, result in dominant optic atrophy despite opposite effects on mitochondrial fusion and fission. Brain 140 2586-2596 PubMed GONUTS page

[PMID:29307555-4] Anding, AL et al. (2018) Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance. Curr. Biol. 28 287-295.e6 PubMed GONUTS page

[PMID:26618722-5] 5.0 ^5.1 Wang, W et al. (2016) Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes. Nat. Med. 22 54-63 PubMed GONUTS page

[PMID:28388446-6] Zheng, X et al. (2017) Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis. Mol. Immunol. 87 23-32 PubMed GONUTS page

[PMID:9472031-7] 7.0 ^7.1 ^7.2 Yoon, Y et al. (1998) A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells. J. Cell Biol. 140 779-93 PubMed GONUTS page

[PMID:11514614-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Smirnova, E et al. (2001) Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol. Biol. Cell 12 2245-56 PubMed GONUTS page

[PMID:26122121-9] Shahni, R et al. (2015) Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission. Brain 138 2834-46 PubMed GONUTS page

[PMID:25767741-10] 10.0 ^10.1 ^10.2 ^10.3 Ortiz-Sandoval, CG et al. () Interaction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteins. Cell Logist 4 e986399 PubMed GONUTS page

[PMID:19279012-11] 11.0 ^11.1 Dagda, RK et al. (2009) Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J. Biol. Chem. 284 13843-55 PubMed GONUTS page

[PMID:19946888-12] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:27145208-13] 13.0 ^13.1 ^13.2 Fahrner, JA et al. (2016) A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy. Am. J. Med. Genet. A 170 2002-11 PubMed GONUTS page

[PMID:26992161-14] Sheffer, R et al. (2016) Postnatal microcephaly and pain insensitivity due to a de novo heterozygous DNM1L mutation causing impaired mitochondrial fission and function. Am. J. Med. Genet. A 170 1603-7 PubMed GONUTS page

[PMID:12499352-15] Karbowski, M et al. (2002) Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J. Cell Biol. 159 931-8 PubMed GONUTS page

[PMID:20850011-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Montessuit, S et al. (2010) Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell 142 889-901 PubMed GONUTS page

[PMID:18353969-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Gandre-Babbe, S & van der Bliek, AM (2008) The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol. Biol. Cell 19 2402-12 PubMed GONUTS page

[PMID:21149567-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 Otera, H et al. (2010) Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J. Cell Biol. 191 1141-58 PubMed GONUTS page

[PMID:22265414-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Wang, Z et al. (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148 228-43 PubMed GONUTS page

[PMID:9570752-20] 20.0 ^20.1 Imoto, M et al. (1998) Identification and functional characterization of a novel human protein highly related to the yeast dynamin-like GTPase Vps1p. J. Cell. Sci. 111 ( Pt 10) 1341-9 PubMed GONUTS page

[PMID:17408615-21] Kobayashi, S et al. (2007) Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis. Exp. Cell Res. 313 1675-86 PubMed GONUTS page

[PMID:23530241-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 Koirala, S et al. (2013) Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc. Natl. Acad. Sci. U.S.A. 110 E1342-51 PubMed GONUTS page

[PMID:19407830-23] Braschi, E et al. (2009) MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. EMBO Rep. 10 748-54 PubMed GONUTS page

[PMID:16874301-24] Yonashiro, R et al. (2006) A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J. 25 3618-26 PubMed GONUTS page

[PMID:23921378-25] 25.0 ^25.1 ^25.2 ^25.3 ^25.4 Palmer, CS et al. (2013) Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. J. Biol. Chem. 288 27584-93 PubMed GONUTS page

[PMID:12618434-26] 26.0 ^26.1 ^26.2 Li, X & Gould, SJ (2003) The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11. J. Biol. Chem. 278 17012-20 PubMed GONUTS page

[PMID:20688057-27] Bonekamp, NA et al. (2010) Dynamin-like protein 1 at the Golgi complex: a novel component of the sorting/targeting machinery en route to the plasma membrane. Exp. Cell Res. 316 3454-67 PubMed GONUTS page

[PMID:21873635-28] 28.00 ^28.01 ^28.02 ^28.03 ^28.04 ^28.05 ^28.06 ^28.07 ^28.08 ^28.09 ^28.10 ^28.11 ^28.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24599962-29] Baba, T et al. (2014) Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics. J. Biol. Chem. 289 11497-511 PubMed GONUTS page

[PMID:23349293-30] 30.0 ^30.1 ^30.2 Korobova, F et al. (2013) An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Science 339 464-7 PubMed GONUTS page

[PMID:21525035-31] Bharti, P et al. (2011) PEX14 is required for microtubule-based peroxisome motility in human cells. J. Cell. Sci. 124 1759-68 PubMed GONUTS page

[PMID:29899447-32] Kalia, R et al. (2018) Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature 558 401-405 PubMed GONUTS page

[PMID:23584531-33] Fröhlich, C et al. (2013) Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein. EMBO J. 32 1280-92 PubMed GONUTS page

[PMID:20436456-34] Landes, T et al. (2010) The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms. EMBO Rep. 11 459-65 PubMed GONUTS page

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HUMAN:DNM1L

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