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HUMAN:DND1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | DND1 (synonyms: RBMS4) | |
| Protein Name(s) | Dead end protein homolog 1
RNA-binding motif, single-stranded-interacting protein 4 | |
| External Links | ||
| UniProt | Q8IYX4 | |
| EMBL | AY321065 BC033496 | |
| CCDS | CCDS4236.1 | |
| RefSeq | NP_919225.1 | |
| UniGene | Hs.591262 | |
| ProteinModelPortal | Q8IYX4 | |
| SMR | Q8IYX4 | |
| BioGrid | 131887 | |
| IntAct | Q8IYX4 | |
| STRING | 9606.ENSP00000445366 | |
| iPTMnet | Q8IYX4 | |
| PhosphoSitePlus | Q8IYX4 | |
| BioMuta | DND1 | |
| DMDM | 60389799 | |
| EPD | Q8IYX4 | |
| PaxDb | Q8IYX4 | |
| PeptideAtlas | Q8IYX4 | |
| PRIDE | Q8IYX4 | |
| DNASU | 373863 | |
| Ensembl | ENST00000542735 | |
| GeneID | 373863 | |
| KEGG | hsa:373863 | |
| UCSC | uc003lgt.4 | |
| CTD | 373863 | |
| DisGeNET | 373863 | |
| GeneCards | DND1 | |
| HGNC | HGNC:23799 | |
| MIM | 609385 | |
| neXtProt | NX_Q8IYX4 | |
| OpenTargets | ENSG00000256453 | |
| PharmGKB | PA134931157 | |
| eggNOG | ENOG410IUE0 ENOG410YAVC | |
| GeneTree | ENSGT00550000074366 | |
| HOGENOM | HOG000112240 | |
| HOVERGEN | HBG051370 | |
| InParanoid | Q8IYX4 | |
| OMA | QSKRECE | |
| OrthoDB | EOG091G0EUB | |
| PhylomeDB | Q8IYX4 | |
| TreeFam | TF314932 | |
| GenomeRNAi | 373863 | |
| PRO | PR:Q8IYX4 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000256453 | |
| CleanEx | HS_DND1 | |
| Genevisible | Q8IYX4 | |
| GO | GO:0005737 GO:0005634 GO:0017091 GO:0000166 GO:0007281 GO:0007275 GO:0060965 | |
| Gene3D | 3.30.70.330 | |
| InterPro | IPR012677 IPR000504 | |
| Pfam | PF00076 | |
| SMART | SM00360 | |
| SUPFAM | SSF54928 | |
| PROSITE | PS50102 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0061158 |
3'-UTR-mediated mRNA destabilization |
ECO:0000314 |
P |
Organism: Homo sapiens. UniProt’s Name: Dead end protein homolog 1. Paper’s Name: RNA-binding protein DND1. Notes: Extended Figure 2g is primarily used, though other figures help to understand the findings. For instance, the paper had previously indicated that DND1 is responsible for mRNA destabilization, and showed in Figure 1E that with an increase in number of DND1 binding sites lead to a greater decrease in median transcript abundance. More importantly, the paper states that “only binding sites located in the 3′ UTR contributed to the DND1-mediated target mRNA reduction.” Extended Figure 2g indeed shows that mRNA targets (of DND1) with binding sites in the 3’-UTR region also have a greater decrease in median transcript abundance. As this data primarily makes use of “FH–DND1-expressing HEK293 cells,” this is a human protein, not a mouse protein. |
complete | |||||
|
involved_in |
GO:0060965 |
negative regulation of gene silencing by miRNA |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0035198 |
miRNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003730 |
mRNA 3'-UTR binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060965 |
negative regulation of gene silencing by miRNA |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002723154 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048255 |
mRNA stabilization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002723154 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017091 |
AU-rich element binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002723154 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2447763 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1891690 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002723140 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1891690 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007281 |
germ cell development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6VY05 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6VY05 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Yamaji, M et al. (2017) DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs. Nature PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Kedde, M et al. (2007) RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell 131 1273-86 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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