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HUMAN:DJB12
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | DNAJB12 | |
| Protein Name(s) | DnaJ homolog subfamily B member 12 | |
| External Links | ||
| UniProt | Q9NXW2 | |
| EMBL | AK000034 AK025942 AK302071 AC091769 BC011812 BC064920 | |
| RefSeq | NP_001002762.2 NP_060096.3 | |
| UniGene | Hs.500013 | |
| PDB | 2CTP | |
| PDBsum | 2CTP | |
| ProteinModelPortal | Q9NXW2 | |
| SMR | Q9NXW2 | |
| BioGrid | 120150 | |
| IntAct | Q9NXW2 | |
| MINT | MINT-1145606 | |
| STRING | 9606.ENSP00000345575 | |
| PhosphoSite | Q9NXW2 | |
| DMDM | 294862531 | |
| MaxQB | Q9NXW2 | |
| PaxDb | Q9NXW2 | |
| PRIDE | Q9NXW2 | |
| DNASU | 54788 | |
| Ensembl | ENST00000444643 | |
| GeneID | 54788 | |
| KEGG | hsa:54788 | |
| UCSC | uc010qjv.1 | |
| CTD | 54788 | |
| GeneCards | GC10M074092 | |
| H-InvDB | HIX0127298 | |
| HGNC | HGNC:14891 | |
| HPA | HPA010642 | |
| MIM | 608376 | |
| neXtProt | NX_Q9NXW2 | |
| PharmGKB | PA27414 | |
| eggNOG | COG0484 | |
| GeneTree | ENSGT00670000097756 | |
| HOGENOM | HOG000233608 | |
| HOVERGEN | HBG051373 | |
| InParanoid | Q9NXW2 | |
| KO | K09518 | |
| OrthoDB | EOG7G4QF8 | |
| PhylomeDB | Q9NXW2 | |
| ChiTaRS | DNAJB12 | |
| EvolutionaryTrace | Q9NXW2 | |
| GenomeRNAi | 54788 | |
| NextBio | 57453 | |
| PRO | PR:Q9NXW2 | |
| Proteomes | UP000005640 | |
| Bgee | Q9NXW2 | |
| CleanEx | HS_DNAJB12 | |
| ExpressionAtlas | Q9NXW2 | |
| Genevestigator | Q9NXW2 | |
| GO | GO:0016021 GO:0016020 | |
| Gene3D | 1.10.287.110 | |
| InterPro | IPR001623 IPR018253 IPR015399 | |
| Pfam | PF00226 PF09320 | |
| PRINTS | PR00625 | |
| SMART | SM00271 | |
| SUPFAM | SSF46565 | |
| PROSITE | PS00636 PS50076 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0031072 |
heat shock protein binding |
ECO:0000314 |
F |
Fig. 5 DnaJ activates ABA binding to GRP78 |
complete | |||||
| GO:0031072 |
heat shock protein binding |
ECO:0000314 |
F |
Fig. 5 DnaJ activates ABA binding to HSP70-2 |
complete | |||||
|
involved_in |
GO:0034622 |
cellular protein-containing complex assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051085 |
chaperone cofactor-dependent protein refolding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030544 |
Hsp70 protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030176 |
integral component of endoplasmic reticulum membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036503 |
ERAD pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071218 |
cellular response to misfolded protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030544 |
Hsp70 protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071218 |
cellular response to misfolded protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036503 |
ERAD pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030176 |
integral component of endoplasmic reticulum membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030544 |
Hsp70 protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071218 |
cellular response to misfolded protein |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001940805 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051085 |
chaperone cofactor-dependent protein refolding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001940805 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030544 |
Hsp70 protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001940805 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030433 |
ubiquitin-dependent ERAD pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001940805 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001940805 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kharenko, OA et al. (2013) Identification and characterization of interactions between abscisic acid and human heat shock protein 70 family members. J. Biochem. 154 383-91 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Li, K et al. (2017) Tetrameric Assembly of K Channels Requires ER-Located Chaperone Proteins. Mol. Cell 65 52-65 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Yamamoto, YH et al. (2010) A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR. Cell Struct. Funct. 35 107-16 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Grove, DE et al. (2011) The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508. Mol. Biol. Cell 22 301-14 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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