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HUMAN:DEF5

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DEFA5 (synonyms: DEF5)
Protein Name(s) Defensin-5

Defensin, alpha 5 HD5(20-94) HD5(23-94) HD5(29-94) HD5(56-94) HD5(63-94)

External Links
UniProt Q01523
EMBL M97925
AF238378
CH471153
BC069690
BC107079
CCDS CCDS5963.1
PIR A44454
RefSeq NP_066290.1
UniGene Hs.655233
PDB 1ZMP
2LXZ
2MIT
3I5W
4E82
4E83
4E86
4RBW
4RBX
5CUI
5CUJ
5CUM
PDBsum 1ZMP
2LXZ
2MIT
3I5W
4E82
4E83
4E86
4RBW
4RBX
5CUI
5CUJ
5CUM
ProteinModelPortal Q01523
SMR Q01523
BioGrid 108034
IntAct Q01523
STRING 9606.ENSP00000329890
BioMuta DEFA5
DMDM 399353
PaxDb Q01523
PeptideAtlas Q01523
PRIDE Q01523
DNASU 1670
Ensembl ENST00000330590
GeneID 1670
KEGG hsa:1670
UCSC uc003wra.2
CTD 1670
DisGeNET 1670
GeneCards DEFA5
HGNC HGNC:2764
HPA CAB069919
HPA015775
MIM 600472
neXtProt NX_Q01523
OpenTargets ENSG00000164816
PharmGKB PA27241
eggNOG ENOG410JFE2
ENOG4111A2R
GeneTree ENSGT00730000111183
HOGENOM HOG000233351
HOVERGEN HBG011703
InParanoid Q01523
KO K05230
OMA EATTQKQ
OrthoDB EOG091G12GE
PhylomeDB Q01523
TreeFam TF338414
Reactome [www.reactome.org/content/detail/R-HSA-1461973 R-HSA-1461973]
[www.reactome.org/content/detail/R-HSA-1462054 R-HSA-1462054]
ChiTaRS DEFA5
EvolutionaryTrace Q01523
GeneWiki DEFA5
GenomeRNAi 1670
PMAP-CutDB Q01523
PRO PR:Q01523
Proteomes UP000005640
Bgee ENSG00000164816
CleanEx HS_DEFA5
Genevisible Q01523
GO GO:0005576
GO:0005615
GO:0005796
GO:0034774
GO:0030133
GO:0019731
GO:0019730
GO:0050832
GO:0045087
GO:0031640
InterPro IPR006081
IPR016327
IPR006080
IPR002366
PANTHER PTHR11876
Pfam PF00323
PF00879
PIRSF PIRSF001875
SMART SM00048
PROSITE PS00269

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0042742

defense response to bacterium

PMID:9169780[1]

ECO:0000314

P

The antibacterial activity of human intestinal defensin 5 was determined using an antimicrobial assay. Figure 1 shows the activity of human defensin 5, in the from of purified rHD-5, against the bacteria L. monocytogenes, E. coli ML35p, and S. typhimurium (wild type, closed symbols; phoP mutant, open symbols). In a concentration dependent manner, rHD-5 showed antibacterial activity against all three bacterial strains tested.

complete
CACAO 12387

GO:0051873

killing by host of symbiont cells

PMID:9169780[1]

ECO:0000314

P

Human intestinal defensin 5 has the ability to kill cells of other organisms. The antimicrobial activity of human intestinal defensin 5 was determined using an antimicrobial assay. Figure 1 shows the activity of human defensin 5, in the form of purified rHD-5, against the bacteria L. monocytogenes, E. coli ML35p, and S. typhimurium. In a concentration dependent manner, rHD-5 showed antibacterial activity against all three bacterial strains tested.

complete
CACAO 12526

GO:0002376

immune system process

PMID:9169780[1]

ECO:0000314

P

Human intestinal defensin 5 plays a role in immune system processes. The antimicrobial immune activity of human intestinal defensin 5 was determined using an antimicrobial assay. Figure 1 shows the activity of human defensin 5, in the form of purified rHD-5, against the bacteria L. monocytogenes, E. coli ML35p, and S. typhimurium. In a concentration dependent manner, rHD-5 showed antibacterial activity against all three bacterial strains tested.

complete
CACAO 12527

GO:0016045

detection of bacterium

PMID:9169780[1]

ECO:0000314

P

Human intestinal defensin 5 has the ability to detect bacterial cells and express antimicrobial activity against them. The antimicrobial activity of human intestinal defensin 5 was determined using an antimicrobial assay. Figure 1 shows the activity of human defensin 5, in the form of purified rHD-5, against the bacteria L. monocytogenes, E. coli ML35p, and S. typhimurium. In a concentration dependent manner, rHD-5 showed antibacterial activity against all three bacterial strains tested.

complete
CACAO 12528

involved_in

GO:0045087

innate immune response

PMID:21861459[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:21861459[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1905710

positive regulation of membrane permeability

PMID:21861459[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

happens_during:(GO:0050829)

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:21861459[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:15616305[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:15616305[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:15616305[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:15616305[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:17088326[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:17088326[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:17088326[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:17088326[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:17088326[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:15616305[3]

ECO:0000305

curator inference used in manual assertion

GO:0031640

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:15616305[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:15616305[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:17088326[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883
PANTHER:PTN002275316

P

Seeded From UniProt

complete

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002275316
UniProtKB:P12838
UniProtKB:P59665
UniProtKB:P59666

P

Seeded From UniProt

complete

involved_in

GO:0051673

membrane disruption in other organism

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99584
MGI:MGI:99592
PANTHER:PTN002275316

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883
PANTHER:PTN002275316
UniProtKB:P12838
UniProtKB:P59666
UniProtKB:P82270
UniProtKB:P82271
UniProtKB:Q01523

P

Seeded From UniProt

complete

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883
MGI:MGI:99582
PANTHER:PTN002275316
UniProtKB:P12838
UniProtKB:P82270
UniProtKB:P82271
UniProtKB:Q01523

P

Seeded From UniProt

complete

involved_in

GO:0019731

antibacterial humoral response

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915259
MGI:MGI:3630383
MGI:MGI:99584
PANTHER:PTN002275316
UniProtKB:P12838
UniProtKB:P59666

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915259
MGI:MGI:3630383
MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883
MGI:MGI:99584
PANTHER:PTN002275315
UniProtKB:P59666

C

Seeded From UniProt

complete

involved_in

GO:0002227

innate immune response in mucosa

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002275316
UniProtKB:P59665
UniProtKB:P59666

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006080
InterPro:IPR006081

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016327

C

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002366
InterPro:IPR006080
InterPro:IPR006081
InterPro:IPR016327

P

Seeded From UniProt

complete

part_of

GO:0034774

secretory granule lumen

Reactome:R-HSA-1462005
Reactome:R-HSA-1461995

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0019730

antimicrobial humoral response

Reactome:R-HSA-6803157

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005796

Golgi lumen

Reactome:R-HSA-1462023
Reactome:R-HSA-1461995

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-1462014
Reactome:R-HSA-1462005
Reactome:R-HSA-1461993
Reactome:R-HSA-1461982
Reactome:R-HSA-1461971

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0295

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0044

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0295

P

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0211

P

Seeded From UniProt

complete

part_of

GO:0030133

transport vesicle

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0244

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Porter, EM et al. (1997) Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infect. Immun. 65 2396-401 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Wanniarachchi, YA et al. (2011) Human defensin 5 disulfide array mutants: disulfide bond deletion attenuates antibacterial activity against Staphylococcus aureus. Biochemistry 50 8005-17 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Ericksen, B et al. (2005) Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob. Agents Chemother. 49 269-75 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Szyk, A et al. (2006) Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci. 15 2749-60 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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