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HUMAN:DCTN1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | DCTN1 | |
Protein Name(s) | Dynactin subunit 1
150 kDa dynein-associated polypeptide DAP-150 DP-150 p135 p150-glued | |
External Links | ||
UniProt | Q14203 | |
EMBL | AF064205 AF064203 AF064204 AF064205 AF064204 AK297286 AK314352 AC005041 CH471053 BC071583 X98801 AF086947 AF086927 AF086928 AF086929 AF086930 AF086931 AF086932 AF086933 AF086934 AF086935 AF086936 AF086937 AF086938 AF086939 AF086940 AF086941 AF086942 AF086943 AF086944 AF086945 AF086946 BT006758 | |
CCDS | CCDS1939.1 CCDS46341.1 CCDS46342.1 CCDS54368.1 CCDS54369.1 | |
RefSeq | NP_001128512.1 NP_001128513.1 NP_001177765.1 NP_001177766.1 NP_004073.2 NP_075408.1 | |
UniGene | Hs.516111 | |
PDB | 1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7 | |
PDBsum | 1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7 | |
ProteinModelPortal | Q14203 | |
SMR | Q14203 | |
BioGrid | 108007 | |
DIP | DIP-31365N | |
IntAct | Q14203 | |
MINT | MINT-5004548 | |
STRING | 9606.ENSP00000354791 | |
PhosphoSite | Q14203 | |
DMDM | 17375490 | |
OGP | Q14203 | |
MaxQB | Q14203 | |
PaxDb | Q14203 | |
PRIDE | Q14203 | |
DNASU | 1639 | |
Ensembl | ENST00000361874 ENST00000394003 ENST00000409240 ENST00000409438 ENST00000409567 | |
GeneID | 1639 | |
KEGG | hsa:1639 | |
UCSC | uc002sku.3 uc002skv.3 uc002skx.3 | |
CTD | 1639 | |
GeneCards | GC02M074588 | |
GeneReviews | DCTN1 | |
H-InvDB | HIX0204314 | |
HGNC | HGNC:2711 | |
HPA | CAB009108 HPA034635 | |
MIM | 105400 168605 601143 607641 | |
neXtProt | NX_Q14203 | |
Orphanet | 803 139589 178509 | |
PharmGKB | PA27180 | |
eggNOG | COG5244 | |
GeneTree | ENSGT00770000120567 | |
HOGENOM | HOG000015352 | |
HOVERGEN | HBG004956 | |
InParanoid | Q14203 | |
KO | K04648 | |
OMA | PEDSTMQ | |
OrthoDB | EOG79W94B | |
PhylomeDB | Q14203 | |
TreeFam | TF105246 | |
Reactome | REACT_121399 REACT_15296 REACT_15364 REACT_15451 REACT_160315 REACT_18273 | |
ChiTaRS | DCTN1 | |
EvolutionaryTrace | Q14203 | |
GeneWiki | DCTN1 | |
GenomeRNAi | 1639 | |
NextBio | 6734 | |
PMAP-CutDB | Q14203 | |
PRO | PR:Q14203 | |
Proteomes | UP000005640 | |
Bgee | Q14203 | |
CleanEx | HS_DCTN1 | |
ExpressionAtlas | Q14203 | |
Genevestigator | Q14203 | |
GO | GO:0031252 GO:0005813 GO:0005737 GO:0005829 GO:0005869 GO:0030286 GO:0000776 GO:0016020 GO:0005874 GO:0000922 GO:0003774 GO:0006987 GO:0019886 GO:0044267 GO:0030968 GO:0000086 GO:0032402 GO:0010970 GO:0000278 GO:0007067 GO:0007399 GO:0042147 | |
Gene3D | 2.30.30.190 | |
InterPro | IPR000938 IPR027663 IPR022157 | |
PANTHER | PTHR18916:SF29 | |
Pfam | PF01302 PF12455 | |
SMART | SM01052 | |
SUPFAM | SSF74924 | |
PROSITE | PS00845 PS50245 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0007399 |
nervous system development |
ECO:0000315 |
P |
Figure 1E is a graphical result of the affect that a mutation in DCTN1 for p150 has on microtubule growth and communication. This is supported by the evidence that p150, when grown in the presence of microtubules, increases microtubule development. In contrast the mutant protein results in a decrease in microtubule affinity leading to neurodegeneration. |
complete | |||||
involved_in |
GO:1990535 |
neuron projection maintenance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0011001) |
Seeded From UniProt |
complete | ||
part_of |
GO:0043005 |
neuron projection |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0011001) |
Seeded From UniProt |
complete | ||
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0011001) |
Seeded From UniProt |
complete | ||
NOT|involved_in |
GO:0098930 |
axonal transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061744 |
motor behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1904398 |
positive regulation of neuromuscular junction development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031116 |
positive regulation of microtubule polymerization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005875 |
microtubule associated complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008017 |
microtubule binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000100) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050905 |
neuromuscular process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0011001) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007528 |
neuromuscular junction development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0011001) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070050 |
neuron cellular homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0011001) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0021517 |
ventral spinal cord development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1990535 |
neuron projection maintenance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0002260) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061744 |
motor behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0048156 |
tau protein binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0099738 |
cell cortex region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000132 |
establishment of mitotic spindle orientation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0120103 |
centriolar subdistal appendage |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005814 |
centriole |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000776 |
kinetochore |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005938 |
cell cortex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060236 |
regulation of mitotic spindle organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0035371 |
microtubule plus-end |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008017 |
microtubule binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:1905515 |
non-motile cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005814 |
centriole |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005874 |
microtubule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005819 |
spindle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031116 |
positive regulation of microtubule polymerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090063 |
positive regulation of microtubule nucleation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008017 |
microtubule binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0015631 |
tubulin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034454 |
microtubule anchoring at centrosome |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010457 |
centriole-centriole cohesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005814 |
centriole |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005874 |
microtubule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051081 |
nuclear envelope disassembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042147 |
retrograde transport, endosome to Golgi |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0030904 |
retromer complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000278 |
mitotic cell cycle |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0005938 |
cell cortex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007399 |
nervous system development |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005874 |
microtubule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000922 |
spindle pole |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000776 |
kinetochore |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0045111 |
intermediate filament cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030424 |
axon |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0098930 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005869 |
dynactin complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010970 |
transport along microtubule |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0070840 |
dynein complex binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0099558 |
maintenance of synapse structure |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
occurs_at:(GO:0031594) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097711 |
ciliary basal body-plasma membrane docking |
Reactome:R-HSA-5620912 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0036498 |
IRE1-mediated unfolded protein response |
Reactome:R-HSA-381070 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
Reactome:R-HSA-2132295 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010389 |
regulation of G2/M transition of mitotic cell cycle |
Reactome:R-HSA-8854518 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006888 |
endoplasmic reticulum to Golgi vesicle-mediated transport |
Reactome:R-HSA-199977 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-8853419 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0000086 |
G2/M transition of mitotic cell cycle |
Reactome:R-HSA-69275 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003774 |
motor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005874 |
microtubule |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030286 |
dynein complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051301 |
cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005938 |
cell cortex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005819 |
spindle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005814 |
centriole |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Araki, E et al. (2014) A novel DCTN1 mutation with late-onset parkinsonism and frontotemporal atrophy. Mov. Disord. 29 1201-4 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Chevalier-Larsen, ES et al. (2008) Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin. Hum. Mol. Genet. 17 1946-55 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Levy, JR et al. (2006) A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation. J. Cell Biol. 172 733-45 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Laird, FM et al. (2008) Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. J. Neurosci. 28 1997-2005 PubMed GONUTS page
- ↑ Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
- ↑ Fumoto, K et al. (2006) GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J. 25 5670-82 PubMed GONUTS page
- ↑ 7.0 7.1 Kiyomitsu, T & Cheeseman, IM (2012) Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation. Nat. Cell Biol. 14 311-7 PubMed GONUTS page
- ↑ 8.0 8.1 Sonnen, KF et al. (2012) 3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. Biol Open 1 965-76 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Kotak, S et al. (2012) Cortical dynein is critical for proper spindle positioning in human cells. J. Cell Biol. 199 97-110 PubMed GONUTS page
- ↑ Kodani, A et al. (2010) Par6 alpha interacts with the dynactin subunit p150 Glued and is a critical regulator of centrosomal protein recruitment. Mol. Biol. Cell 21 3376-85 PubMed GONUTS page
- ↑ Zhapparova, ON et al. (2013) Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome. Mol. Biol. Cell 24 3205-14 PubMed GONUTS page
- ↑ 12.0 12.1 Nirschl, JJ et al. (2016) α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Cell Rep 14 2637-52 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 Chen, TY et al. (2015) Cell Cycle-Dependent Localization of Dynactin Subunit p150 glued at Centrosome. J. Cell. Biochem. 116 2049-60 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 Lazarus, JE et al. (2013) Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor. PLoS Biol. 11 e1001611 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Kodani, A et al. (2013) Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 32 597-607 PubMed GONUTS page
- ↑ Kuh, GF et al. (2012) Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued). Cell Tissue Res. 350 13-26 PubMed GONUTS page
- ↑ 17.0 17.1 Li, H et al. (2010) Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase. Proc. Natl. Acad. Sci. U.S.A. 107 14633-8 PubMed GONUTS page
- ↑ 18.0 18.1 Wassmer, T et al. (2009) The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev. Cell 17 110-22 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ 20.0 20.1 Holzbaur, EL et al. (1991) Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued. Nature 351 579-83 PubMed GONUTS page
- ↑ Zhu, M et al. (2013) MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression. J. Cell Biol. 200 773-87 PubMed GONUTS page
- ↑ Haghnia, M et al. (2007) Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment. Mol. Biol. Cell 18 2081-9 PubMed GONUTS page
- ↑ Bharti, P et al. (2011) PEX14 is required for microtubule-based peroxisome motility in human cells. J. Cell. Sci. 124 1759-68 PubMed GONUTS page
- ↑ Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
- ↑ Cassimeris, L & Morabito, J (2004) TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Mol. Biol. Cell 15 1580-90 PubMed GONUTS page
- ↑ Chan, YW et al. (2009) Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. J. Cell Biol. 185 859-74 PubMed GONUTS page
a
c
- Catarrhini
- GO:0005938 ! cell cortex
- GO:0099738 ! cell cortex region
- GO:0007049 ! cell cycle
- GO:0051301 ! cell division
- GO:0120103 ! centriolar subdistal appendage
- GO:0005814 ! centriole
- GO:0010457 ! centriole-centriole cohesion
- GO:0005813 ! centrosome
- Chordata
- GO:0097711 ! ciliary basal body-plasma membrane docking
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
e
i
m
- GO:0099558 ! maintenance of synapse structure
- Mammalia
- GO:0016020 ! membrane
- Metazoa
- GO:0005874 ! microtubule
- GO:0034454 ! microtubule anchoring at centrosome
- GO:0005815 ! microtubule organizing center
- GO:0035371 ! microtubule plus-end
- GO:0008017 ! microtubule binding
- GO:0005875 ! microtubule associated complex
- GO:0000278 ! mitotic cell cycle
- GO:0003774 ! motor activity
- GO:0061744 ! motor behavior
n
- GO:0007399 ! nervous system development
- GO:0050905 ! neuromuscular process
- GO:0031594 ! neuromuscular junction
- GO:0007528 ! neuromuscular junction development
- GO:0043025 ! neuronal cell body
- GO:0070050 ! neuron cellular homeostasis
- GO:1990535 ! neuron projection maintenance
- GO:0043005 ! neuron projection
- GO:1905515 ! non-motile cilium assembly
- GO:0005635 ! nuclear envelope
- GO:0051081 ! nuclear membrane disassembly
- GO:0005634 ! nucleus
p
r
t