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HUMAN:DCTN1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DCTN1
Protein Name(s) Dynactin subunit 1

150 kDa dynein-associated polypeptide DAP-150 DP-150 p135 p150-glued

External Links
UniProt Q14203
EMBL AF064205
AF064203
AF064204
AF064205
AF064204
AK297286
AK314352
AC005041
CH471053
BC071583
X98801
AF086947
AF086927
AF086928
AF086929
AF086930
AF086931
AF086932
AF086933
AF086934
AF086935
AF086936
AF086937
AF086938
AF086939
AF086940
AF086941
AF086942
AF086943
AF086944
AF086945
AF086946
BT006758
CCDS CCDS1939.1
CCDS46341.1
CCDS46342.1
CCDS54368.1
CCDS54369.1
RefSeq NP_001128512.1
NP_001128513.1
NP_001177765.1
NP_001177766.1
NP_004073.2
NP_075408.1
UniGene Hs.516111
PDB 1TXQ
2COY
2HKN
2HKQ
2HL3
2HL5
2HQH
3E2U
3TQ7
PDBsum 1TXQ
2COY
2HKN
2HKQ
2HL3
2HL5
2HQH
3E2U
3TQ7
ProteinModelPortal Q14203
SMR Q14203
BioGrid 108007
DIP DIP-31365N
IntAct Q14203
MINT MINT-5004548
STRING 9606.ENSP00000354791
PhosphoSite Q14203
DMDM 17375490
OGP Q14203
MaxQB Q14203
PaxDb Q14203
PRIDE Q14203
DNASU 1639
Ensembl ENST00000361874
ENST00000394003
ENST00000409240
ENST00000409438
ENST00000409567
GeneID 1639
KEGG hsa:1639
UCSC uc002sku.3
uc002skv.3
uc002skx.3
CTD 1639
GeneCards GC02M074588
GeneReviews DCTN1
H-InvDB HIX0204314
HGNC HGNC:2711
HPA CAB009108
HPA034635
MIM 105400
168605
601143
607641
neXtProt NX_Q14203
Orphanet 803
139589
178509
PharmGKB PA27180
eggNOG COG5244
GeneTree ENSGT00770000120567
HOGENOM HOG000015352
HOVERGEN HBG004956
InParanoid Q14203
KO K04648
OMA PEDSTMQ
OrthoDB EOG79W94B
PhylomeDB Q14203
TreeFam TF105246
Reactome REACT_121399
REACT_15296
REACT_15364
REACT_15451
REACT_160315
REACT_18273
ChiTaRS DCTN1
EvolutionaryTrace Q14203
GeneWiki DCTN1
GenomeRNAi 1639
NextBio 6734
PMAP-CutDB Q14203
PRO PR:Q14203
Proteomes UP000005640
Bgee Q14203
CleanEx HS_DCTN1
ExpressionAtlas Q14203
Genevestigator Q14203
GO GO:0031252
GO:0005813
GO:0005737
GO:0005829
GO:0005869
GO:0030286
GO:0000776
GO:0016020
GO:0005874
GO:0000922
GO:0003774
GO:0006987
GO:0019886
GO:0044267
GO:0030968
GO:0000086
GO:0032402
GO:0010970
GO:0000278
GO:0007067
GO:0007399
GO:0042147
Gene3D 2.30.30.190
InterPro IPR000938
IPR027663
IPR022157
PANTHER PTHR18916:SF29
Pfam PF01302
PF12455
SMART SM01052
SUPFAM SSF74924
PROSITE PS00845
PS50245

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007399

nervous system development

PMID:24676999[1]

ECO:0000315

P

Figure 1E is a graphical result of the affect that a mutation in DCTN1 for p150 has on microtubule growth and communication. This is supported by the evidence that p150, when grown in the presence of microtubules, increases microtubule development. In contrast the mutant protein results in a decrease in microtubule affinity leading to neurodegeneration.

complete
CACAO 10056

involved_in

GO:1990535

neuron projection maintenance

PMID:18364389[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0011001)

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:18364389[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0011001)

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

PMID:18364389[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0011001)

Seeded From UniProt

complete

NOT|involved_in

GO:0098930

axonal transport

PMID:18364389[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061744

motor behavior

PMID:18364389[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904398

positive regulation of neuromuscular junction development

PMID:18364389[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031116

positive regulation of microtubule polymerization

PMID:16505168[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005875

microtubule associated complex

PMID:16505168[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

PMID:16505168[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:18305234[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000100)

Seeded From UniProt

complete

involved_in

GO:0050905

neuromuscular process

PMID:18305234[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0011001)

Seeded From UniProt

complete

involved_in

GO:0007528

neuromuscular junction development

PMID:18305234[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0011001)

Seeded From UniProt

complete

involved_in

GO:0070050

neuron cellular homeostasis

PMID:18305234[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0011001)

Seeded From UniProt

complete

involved_in

GO:0021517

ventral spinal cord development

PMID:18305234[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1990535

neuron projection maintenance

PMID:18305234[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002260)

Seeded From UniProt

complete

involved_in

GO:0061744

motor behavior

PMID:18305234[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0048156

tau protein binding

PMID:28386764[5]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:17139249[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P49841

F

Seeded From UniProt

complete

part_of

GO:0099738

cell cortex region

PMID:22327364[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000132

establishment of mitotic spindle orientation

PMID:22327364[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0120103

centriolar subdistal appendage

PMID:23213374[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:23213374[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:23027904[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005938

cell cortex

PMID:23027904[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060236

regulation of mitotic spindle organization

PMID:23027904[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:20719959[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:23985322[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0035371

microtubule plus-end

PMID:26972003[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

PMID:26972003[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1905515

non-motile cilium assembly

PMID:25774020[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:25774020[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:25774020[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

PMID:25774020[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005819

spindle

PMID:25774020[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0031116

positive regulation of microtubule polymerization

PMID:23874158[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090063

positive regulation of microtubule nucleation

PMID:23874158[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

PMID:23874158[14]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0015631

tubulin binding

PMID:23874158[14]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0034454

microtubule anchoring at centrosome

PMID:23386061[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010457

centriole-centriole cohesion

PMID:23386061[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:23386061[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

PMID:22777741[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

PMID:20679239[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051081

nuclear envelope disassembly

PMID:20679239[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042147

retrograde transport, endosome to Golgi

PMID:19619496[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0030904

retromer complex

PMID:19619496[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[19]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:1828535[20]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0005938

cell cortex

PMID:23509069[21]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

PMID:17360970[22]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

PMID:21525035[23]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21399614[24]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

PMID:14718566[25]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:19468067[26]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0045111

intermediate filament cytoskeleton

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0098930

C

Seeded From UniProt

complete

part_of

GO:0005869

dynactin complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027663

C

Seeded From UniProt

complete

involved_in

GO:0010970

transport along microtubule

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027663

P

Seeded From UniProt

complete

enables

GO:0070840

dynein complex binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027663

F

Seeded From UniProt

complete

involved_in

GO:0099558

maintenance of synapse structure

PMID:18305234[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

occurs_at:(GO:0031594)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:1828535[20]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0097711

ciliary basal body-plasma membrane docking

Reactome:R-HSA-5620912

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036498

IRE1-mediated unfolded protein response

Reactome:R-HSA-381070

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019886

antigen processing and presentation of exogenous peptide antigen via MHC class II

Reactome:R-HSA-2132295

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010389

regulation of G2/M transition of mitotic cell cycle

Reactome:R-HSA-8854518

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006888

endoplasmic reticulum to Golgi vesicle-mediated transport

Reactome:R-HSA-199977

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8853419
Reactome:R-HSA-8853405
Reactome:R-HSA-8849353
Reactome:R-HSA-8849350
Reactome:R-HSA-6809006
Reactome:R-HSA-6809003
Reactome:R-HSA-5638009
Reactome:R-HSA-5626699
Reactome:R-HSA-5626681
Reactome:R-HSA-5626228
Reactome:R-HSA-5626227
Reactome:R-HSA-5626223
Reactome:R-HSA-5626220
Reactome:R-HSA-5617816
Reactome:R-HSA-380508
Reactome:R-HSA-380455
Reactome:R-HSA-380316
Reactome:R-HSA-380311
Reactome:R-HSA-380303
Reactome:R-HSA-380294
Reactome:R-HSA-380283
Reactome:R-HSA-380272
Reactome:R-HSA-3000319
Reactome:R-HSA-3000310
Reactome:R-HSA-2574845
Reactome:R-HSA-2574840
Reactome:R-HSA-2213248
Reactome:R-HSA-1791092

ECO:0000304

author statement supported by traceable reference used in manual assertion




























C

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

Reactome:R-HSA-69275

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

enables

GO:0003774

motor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0243

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

part_of

GO:0030286

dynein complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0243

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0005938

cell cortex

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0138

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0178

C

Seeded From UniProt

complete

part_of

GO:0005819

spindle

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0251

C

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0046

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Araki, E et al. (2014) A novel DCTN1 mutation with late-onset parkinsonism and frontotemporal atrophy. Mov. Disord. 29 1201-4 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Chevalier-Larsen, ES et al. (2008) Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin. Hum. Mol. Genet. 17 1946-55 PubMed GONUTS page
  3. 3.0 3.1 3.2 Levy, JR et al. (2006) A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation. J. Cell Biol. 172 733-45 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Laird, FM et al. (2008) Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. J. Neurosci. 28 1997-2005 PubMed GONUTS page
  5. Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
  6. Fumoto, K et al. (2006) GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J. 25 5670-82 PubMed GONUTS page
  7. 7.0 7.1 Kiyomitsu, T & Cheeseman, IM (2012) Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation. Nat. Cell Biol. 14 311-7 PubMed GONUTS page
  8. 8.0 8.1 Sonnen, KF et al. (2012) 3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. Biol Open 1 965-76 PubMed GONUTS page
  9. 9.0 9.1 9.2 Kotak, S et al. (2012) Cortical dynein is critical for proper spindle positioning in human cells. J. Cell Biol. 199 97-110 PubMed GONUTS page
  10. Kodani, A et al. (2010) Par6 alpha interacts with the dynactin subunit p150 Glued and is a critical regulator of centrosomal protein recruitment. Mol. Biol. Cell 21 3376-85 PubMed GONUTS page
  11. Zhapparova, ON et al. (2013) Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome. Mol. Biol. Cell 24 3205-14 PubMed GONUTS page
  12. 12.0 12.1 Nirschl, JJ et al. (2016) α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Cell Rep 14 2637-52 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 13.4 Chen, TY et al. (2015) Cell Cycle-Dependent Localization of Dynactin Subunit p150 glued at Centrosome. J. Cell. Biochem. 116 2049-60 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 Lazarus, JE et al. (2013) Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor. PLoS Biol. 11 e1001611 PubMed GONUTS page
  15. 15.0 15.1 15.2 Kodani, A et al. (2013) Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 32 597-607 PubMed GONUTS page
  16. Kuh, GF et al. (2012) Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued). Cell Tissue Res. 350 13-26 PubMed GONUTS page
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