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HUMAN:DCP1A

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DCP1A (synonyms: SMIF)
Protein Name(s) mRNA-decapping enzyme 1A

Smad4-interacting transcriptional co-activator Transcription factor SMIF

External Links
UniProt Q9NPI6
EMBL AY146651
AJ275986
AK001969
AK295205
AC097015
AC112218
BC007439
RefSeq NP_001277133.1
NP_001277134.1
NP_001277135.1
NP_001277136.1
NP_060873.4
UniGene Hs.476353
PDB 2WX3
4B6H
PDBsum 2WX3
4B6H
ProteinModelPortal Q9NPI6
SMR Q9NPI6
BioGrid 120914
DIP DIP-31292N
IntAct Q9NPI6
MINT MINT-5005647
STRING 9606.ENSP00000294241
TCDB 3.A.18.1.1
PhosphoSite Q9NPI6
DMDM 296434475
MaxQB Q9NPI6
PaxDb Q9NPI6
PRIDE Q9NPI6
DNASU 55802
Ensembl ENST00000294241
ENST00000610213
GeneID 55802
KEGG hsa:55802
UCSC uc021wzi.1
CTD 55802
GeneCards GC03M053319
HGNC HGNC:18714
HPA HPA013202
MIM 607010
neXtProt NX_Q9NPI6
PharmGKB PA134931379
eggNOG NOG314415
GeneTree ENSGT00390000014855
HOVERGEN HBG051320
InParanoid Q9NPI6
KO K12610
PhylomeDB Q9NPI6
Reactome REACT_20518
REACT_24915
REACT_25064
ChiTaRS DCP1A
EvolutionaryTrace Q9NPI6
GeneWiki DCP1A
GenomeRNAi 55802
NextBio 35472061
PRO PR:Q9NPI6
Proteomes UP000005640
CleanEx HS_DCP1A
Genevestigator Q9NPI6
GO GO:0000932
GO:0005829
GO:0043231
GO:0016020
GO:0005634
GO:0016787
GO:0042802
GO:0043928
GO:0010467
GO:0016071
GO:0000288
GO:0000184
GO:0016070
Gene3D 2.30.29.30
InterPro IPR010334
IPR011993
PANTHER PTHR16290
Pfam PF06058

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1903608

protein localization to cytoplasmic stress granule

PMID:24965446[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:24965446[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000932

P-body

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q91YD3

C

Seeded From UniProt

complete

involved_in

GO:0031087

deadenylation-independent decapping of nuclear-transcribed mRNA

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000418281
PomBase:SPBC3B9.21
TAIR:locus:2201821

P

Seeded From UniProt

complete

part_of

GO:0000932

P-body

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0034921
MGI:MGI:1923151
MGI:MGI:2442404
PANTHER:PTN000418281
PomBase:SPBC3B9.21
SGD:S000005509
TAIR:locus:2201821
WB:WBGene00021929

C

Seeded From UniProt

complete

involved_in

GO:0000290

deadenylation-dependent decapping of nuclear-transcribed mRNA

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000418281
PomBase:SPBC3B9.21
SGD:S000005509
WB:WBGene00021929

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:19966221[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NPI6

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16364915[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NPI6

F

Seeded From UniProt

complete

part_of

GO:0036464

cytoplasmic ribonucleoprotein granule

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019894

kinesin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4AE80
ensembl:ENSRNOP00000021473

F

Seeded From UniProt

complete

part_of

GO:0000932

P-body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91YD3
ensembl:ENSMUSP00000022535

C

Seeded From UniProt

complete

involved_in

GO:0000290

deadenylation-dependent decapping of nuclear-transcribed mRNA

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010334

P

Seeded From UniProt

complete

enables

GO:0008047

enzyme activator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010334

F

Seeded From UniProt

complete

involved_in

GO:0043085

positive regulation of catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010334

P

Seeded From UniProt

complete

involved_in

GO:0043928

exonucleolytic catabolism of deadenylated mRNA

Reactome:R-HSA-430039

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043488

regulation of mRNA stability

Reactome:R-HSA-450513
Reactome:R-HSA-450385

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-927813
Reactome:R-HSA-450488
Reactome:R-HSA-450431
Reactome:R-HSA-429860

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Reactome:R-HSA-927802

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0866

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0000932

P-body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0230

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Jefferson, M et al. (2014) Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex. J. Virol. 88 10340-53 PubMed GONUTS page
  2. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Tritschler, F et al. (2009) DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc. Natl. Acad. Sci. U.S.A. 106 21591-6 PubMed GONUTS page
  5. ↑ Fenger-Grøn, M et al. (2005) Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol. Cell 20 905-15 PubMed GONUTS page
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