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HUMAN:DBR1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DBR1
Protein Name(s) Lariat debranching enzyme
External Links
UniProt Q9UK59
EMBL AF180919
AK000116
BC009472
CCDS CCDS33863.1
RefSeq NP_057300.2
UniGene Hs.477700
ProteinModelPortal Q9UK59
SMR Q9UK59
BioGrid 119344
IntAct Q9UK59
STRING 9606.ENSP00000260803
PhosphoSite Q9UK59
DMDM 115311701
MaxQB Q9UK59
PaxDb Q9UK59
PeptideAtlas Q9UK59
PRIDE Q9UK59
DNASU 51163
Ensembl ENST00000260803
GeneID 51163
KEGG hsa:51163
UCSC uc003ert.3
uc003eru.3
CTD 51163
GeneCards GC03M137879
HGNC HGNC:15594
HPA HPA035365
MIM 607024
neXtProt NX_Q9UK59
PharmGKB PA27166
eggNOG NOG133819
GeneTree ENSGT00510000047481
HOGENOM HOG000216468
HOVERGEN HBG079917
InParanoid Q9UK59
KO K18328
OMA KVPCNFS
OrthoDB EOG7BW0J7
PhylomeDB Q9UK59
TreeFam TF313221
GeneWiki DBR1
GenomeRNAi 51163
NextBio 54089
PRO PR:Q9UK59
Proteomes UP000005640
Bgee Q9UK59
CleanEx HS_DBR1
ExpressionAtlas Q9UK59
Genevestigator Q9UK59
GO GO:0005634
GO:0046872
GO:0044822
GO:0008419
GO:0000398
GO:0090502
GO:0000375
Gene3D 3.60.21.10
InterPro IPR004843
IPR007708
IPR029052
Pfam PF05011
PF00149
SUPFAM SSF56300

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0003723

RNA binding

PMID:22658674[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008419

RNA lariat debranching enzyme activity

PMID:10982890[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10982890[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000375

RNA splicing, via transesterification reactions

PMID:10982890[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008419

RNA lariat debranching enzyme activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1931520
PANTHER:PTN000304155
PomBase:SPAC17A5.02c
SGD:S000001632
UniProtKB:A0A1D8PPT8
UniProtKB:Q9UK59

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000304155
UniProtKB:Q9UK59

C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1931520
PANTHER:PTN000304155
SGD:S000001632

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008419

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008419

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008419

P

Seeded From UniProt

complete

enables

GO:0008419

RNA lariat debranching enzyme activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q923B1
ensembl:ENSMUSP00000070991

F

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q923B1
ensembl:ENSMUSP00000070991

P

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007708

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004843

F

Seeded From UniProt

complete

enables

GO:0016788

hydrolase activity, acting on ester bonds

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007708

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  2. 2.0 2.1 2.2 Kim, JW et al. (2000) Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants. Nucleic Acids Res. 28 3666-73 PubMed GONUTS page
  3. 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page