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HUMAN:D106A

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DEFB106B (synonyms: BD6, DEFB106, DEFB6)
Protein Name(s) Beta-defensin 106

Beta-defensin 6 BD-6 DEFB-6 Defensin, beta 106

External Links
UniProt Q8N104
EMBL AY122466
AB089181
AF529417
BC100844
BC100845
BC100846
BC100847
BC110062
BC111688
AF540978
CCDS CCDS34813.1
CCDS34833.1
RefSeq NP_001035794.1
NP_689464.1
UniGene Hs.511958
Hs.535925
PDB 2LWL
PDBsum 2LWL
ProteinModelPortal Q8N104
SMR Q8N104
STRING 9606.ENSP00000334364
DMDM 26392715
PRIDE Q8N104
DNASU 245909
Ensembl ENST00000335186
ENST00000335479
ENST00000621252
GeneID 245909
503841
KEGG hsa:245909
hsa:503841
UCSC uc003wro.1
CTD 245909
503841
GeneCards GC08M007340
GC08P007682
HGNC HGNC:18088
HGNC:28879
HPA HPA045592
neXtProt NX_Q8N104
PharmGKB PA142671992
eggNOG NOG42673
GeneTree ENSGT00390000005938
HOGENOM HOG000112137
HOVERGEN HBG051285
InParanoid Q8N104
OMA SLKCCLT
OrthoDB EOG77DJ91
PhylomeDB Q8N104
Reactome REACT_115846
REACT_115897
GeneWiki DEFB106A
NextBio 91749
PRO PR:Q8N104
Proteomes UP000005640
UP000005640
Bgee Q8N104
CleanEx HS_DEFB106A
HS_DEFB106B
Genevestigator Q8N104
GO GO:0005576
GO:0042742
InterPro IPR025933
Pfam PF13841

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0019898

extrinsic component of membrane

PMID:23938203[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:24189797[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24189797[2]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:1001590)
  • part_of:(CL:0002559)

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

PMID:24189797[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001530

lipopolysaccharide binding

PMID:24189797[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0061760

antifungal innate immune response

PMID:24189797[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:24189797[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:24189797[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031727

CCR2 chemokine receptor binding

PMID:23938203[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:1990742

microvesicle

PMID:23938203[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR025933

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR025933

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0044

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0211

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 De Paula, VS et al. (2013) Structural basis for the interaction of human β-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles. J. Mol. Biol. 425 4479-95 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Xin, A et al. (2014) Soluble fusion expression, characterization and localization of human β-defensin 6. Mol Med Rep 9 149-55 PubMed GONUTS page