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HUMAN:CTLA4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CTLA4 (synonyms: CD152)
Protein Name(s) Cytotoxic T-lymphocyte protein 4

Cytotoxic T-lymphocyte-associated antigen 4 CTLA-4

External Links
UniProt P16410
EMBL L15006
M74363
AF411058
AY792514
AY999702
DQ785106
AF414120
DQ357942
AC010138
BC074842
BC074893
AH002733
U90273
AF142144
CCDS CCDS2362.1
CCDS42803.1
PIR S08614
RefSeq NP_001032720.1
NP_005205.2
UniGene Hs.247824
PDB 1AH1
1H6E
1I85
1I8L
2X44
3BX7
3OSK
PDBsum 1AH1
1H6E
1I85
1I8L
2X44
3BX7
3OSK
ProteinModelPortal P16410
SMR P16410
BioGrid 107875
IntAct P16410
MINT MINT-6631153
STRING 9606.ENSP00000303939
ChEMBL CHEMBL2364164
DrugBank DB06186
GuidetoPHARMACOLOGY 2743
PhosphoSite P16410
DMDM 27735177
PaxDb P16410
PRIDE P16410
Ensembl ENST00000295854
ENST00000302823
ENST00000427473
ENST00000472206
GeneID 1493
KEGG hsa:1493
UCSC uc002vak.2
uc010fty.2
CTD 1493
GeneCards GC02P204696
HGNC HGNC:2505
MIM 109100
123890
152700
601388
609755
610424
neXtProt NX_P16410
Orphanet 555
900
855
536
PharmGKB PA27006
eggNOG NOG42442
GeneTree ENSGT00530000063873
HOVERGEN HBG057978
InParanoid P16410
KO K06538
OMA FSKGMHV
OrthoDB EOG70GMGW
PhylomeDB P16410
TreeFam TF335679
Reactome REACT_19405
EvolutionaryTrace P16410
GeneWiki CTLA-4
GenomeRNAi 1493
NextBio 13603519
PRO PR:P16410
Proteomes UP000005640
Bgee P16410
CleanEx HS_CTLA4
ExpressionAtlas P16410
Genevestigator P16410
GO GO:0045334
GO:0009897
GO:0005794
GO:0005887
GO:0048471
GO:0005886
GO:0050853
GO:0006974
GO:0006955
GO:0030889
GO:0050777
GO:0045590
GO:0042130
GO:0043065
GO:0031295
Gene3D 2.60.40.10
InterPro IPR008096
IPR013783
IPR013106
IPR003596
Pfam PF07686
PRINTS PR01720
SMART SM00406

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005887

integral component of plasma membrane

PMID:28484017[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:15814706[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045590

negative regulation of regulatory T cell differentiation

PMID:18641304[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0045334

clathrin-coated endocytic vesicle

PMID:15814706[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:18641304[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:15814706[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050853

B cell receptor signaling pathway

PMID:17875758[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:17875758[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030889

negative regulation of B cell proliferation

PMID:17875758[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:17875758[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050853

B cell receptor signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000160996
UniProtKB:P16410

P

Seeded From UniProt

complete

involved_in

GO:0050852

T cell receptor signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88327
PANTHER:PTN002608477

P

Seeded From UniProt

complete

involved_in

GO:0045590

negative regulation of regulatory T cell differentiation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000160996
UniProtKB:P16410

P

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88327
MGI:MGI:88556
PANTHER:PTN002608477
UniProtKB:P10747
UniProtKB:P16410

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88327
PANTHER:PTN002608477
RGD:2299
UniProtKB:P10747
UniProtKB:P16410

P

Seeded From UniProt

complete

part_of

GO:0098636

protein complex involved in cell adhesion

PMID:7544393[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050777

negative regulation of immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A096MJE4
ensembl:ENSRNOP00000073071

P

Seeded From UniProt

complete

involved_in

GO:0042130

negative regulation of T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A096MJE4
ensembl:ENSRNOP00000073071

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008096

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008096

C

Seeded From UniProt

complete

involved_in

GO:0042129

regulation of T cell proliferation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040216

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:3220103[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:3220103[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045589

regulation of regulatory T cell differentiation

Reactome:R-HSA-8877330

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031295

T cell costimulation

Reactome:R-HSA-388841

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-8877421
Reactome:R-HSA-389532
Reactome:R-HSA-388833
Reactome:R-HSA-388829
Reactome:R-HSA-388809

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1064

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Ramagopal, UA et al. (2017) Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab. Proc. Natl. Acad. Sci. U.S.A. 114 E4223-E4232 PubMed GONUTS page
  2. 2.0 2.1 2.2 Mead, KI et al. (2005) Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells. J. Immunol. 174 4803-11 PubMed GONUTS page
  3. 3.0 3.1 Zheng, Y et al. (2008) Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3. J. Immunol. 181 1683-91 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Joshi, AD et al. (2007) ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Clin. Cancer Res. 13 5295-304 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. Fargeas, CA et al. (1995) Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J. Exp. Med. 182 667-75 PubMed GONUTS page
  7. 7.0 7.1 Dariavach, P et al. (1988) Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. Eur. J. Immunol. 18 1901-5 PubMed GONUTS page