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HUMAN:CTLA4
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | CTLA4 (synonyms: CD152) | |
Protein Name(s) | Cytotoxic T-lymphocyte protein 4
Cytotoxic T-lymphocyte-associated antigen 4 CTLA-4 | |
External Links | ||
UniProt | P16410 | |
EMBL | L15006 M74363 AF411058 AY792514 AY999702 DQ785106 AF414120 DQ357942 AC010138 BC074842 BC074893 AH002733 U90273 AF142144 | |
CCDS | CCDS2362.1 CCDS42803.1 | |
PIR | S08614 | |
RefSeq | NP_001032720.1 NP_005205.2 | |
UniGene | Hs.247824 | |
PDB | 1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK | |
PDBsum | 1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK | |
ProteinModelPortal | P16410 | |
SMR | P16410 | |
BioGrid | 107875 | |
IntAct | P16410 | |
MINT | MINT-6631153 | |
STRING | 9606.ENSP00000303939 | |
ChEMBL | CHEMBL2364164 | |
DrugBank | DB06186 | |
GuidetoPHARMACOLOGY | 2743 | |
PhosphoSite | P16410 | |
DMDM | 27735177 | |
PaxDb | P16410 | |
PRIDE | P16410 | |
Ensembl | ENST00000295854 ENST00000302823 ENST00000427473 ENST00000472206 | |
GeneID | 1493 | |
KEGG | hsa:1493 | |
UCSC | uc002vak.2 uc010fty.2 | |
CTD | 1493 | |
GeneCards | GC02P204696 | |
HGNC | HGNC:2505 | |
MIM | 109100 123890 152700 601388 609755 610424 | |
neXtProt | NX_P16410 | |
Orphanet | 555 900 855 536 | |
PharmGKB | PA27006 | |
eggNOG | NOG42442 | |
GeneTree | ENSGT00530000063873 | |
HOVERGEN | HBG057978 | |
InParanoid | P16410 | |
KO | K06538 | |
OMA | FSKGMHV | |
OrthoDB | EOG70GMGW | |
PhylomeDB | P16410 | |
TreeFam | TF335679 | |
Reactome | REACT_19405 | |
EvolutionaryTrace | P16410 | |
GeneWiki | CTLA-4 | |
GenomeRNAi | 1493 | |
NextBio | 13603519 | |
PRO | PR:P16410 | |
Proteomes | UP000005640 | |
Bgee | P16410 | |
CleanEx | HS_CTLA4 | |
ExpressionAtlas | P16410 | |
Genevestigator | P16410 | |
GO | GO:0045334 GO:0009897 GO:0005794 GO:0005887 GO:0048471 GO:0005886 GO:0050853 GO:0006974 GO:0006955 GO:0030889 GO:0050777 GO:0045590 GO:0042130 GO:0043065 GO:0031295 | |
Gene3D | 2.60.40.10 | |
InterPro | IPR008096 IPR013783 IPR013106 IPR003596 | |
Pfam | PF07686 | |
PRINTS | PR01720 | |
SMART | SM00406 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045590 |
negative regulation of regulatory T cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0045334 |
clathrin-coated endocytic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050853 |
B cell receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030889 |
negative regulation of B cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050853 |
B cell receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000160996 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050852 |
T cell receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88327 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045590 |
negative regulation of regulatory T cell differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000160996 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88327 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002376 |
immune system process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88327 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0098636 |
protein complex involved in cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050777 |
negative regulation of immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A096MJE4 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042130 |
negative regulation of T cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A096MJE4 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006955 |
immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042129 |
regulation of T cell proliferation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006955 |
immune response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045589 |
regulation of regulatory T cell differentiation |
Reactome:R-HSA-8877330 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031295 |
T cell costimulation |
Reactome:R-HSA-388841 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-8877421 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002250 |
adaptive immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ramagopal, UA et al. (2017) Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab. Proc. Natl. Acad. Sci. U.S.A. 114 E4223-E4232 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Mead, KI et al. (2005) Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells. J. Immunol. 174 4803-11 PubMed GONUTS page
- ↑ 3.0 3.1 Zheng, Y et al. (2008) Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3. J. Immunol. 181 1683-91 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Joshi, AD et al. (2007) ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Clin. Cancer Res. 13 5295-304 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Fargeas, CA et al. (1995) Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J. Exp. Med. 182 667-75 PubMed GONUTS page
- ↑ 7.0 7.1 Dariavach, P et al. (1988) Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. Eur. J. Immunol. 18 1901-5 PubMed GONUTS page
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