HUMAN:CTIP

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RBBP8 (synonyms: CTIP)
Protein Name(s)	DNA endonuclease RBBP8 CtBP-interacting protein CtIP Retinoblastoma-binding protein 8 RBBP-8 Retinoblastoma-interacting protein and myosin-like RIM Sporulation in the absence of SPO11 protein 2 homolog SAE2
External Links
UniProt	Q99708
EMBL	AF043431 U72066 AK292481 BX648221 AC091147 AC106033 CH471088 BC030590
CCDS	CCDS11874.1 CCDS11875.1
RefSeq	NP_002885.1 NP_976036.1 NP_976037.1 XP_006722582.1 XP_006722583.1 XP_006722584.1 XP_011524434.1
UniGene	Hs.546282
PDB	2L4Z 4D2H
PDBsum	2L4Z 4D2H
ProteinModelPortal	Q99708
SMR	Q99708
BioGrid	111867
DIP	DIP-24244N
IntAct	Q99708
MINT	MINT-102295
STRING	9606.ENSP00000323050
iPTMnet	Q99708
PhosphoSitePlus	Q99708
BioMuta	RBBP8
DMDM	116242745
EPD	Q99708
MaxQB	Q99708
PaxDb	Q99708
PeptideAtlas	Q99708
PRIDE	Q99708
DNASU	5932
Ensembl	ENST00000327155 ENST00000399722 ENST00000399725
GeneID	5932
KEGG	hsa:5932
UCSC	uc002ktw.4
CTD	5932
DisGeNET	5932
GeneCards	MIR4741 RBBP8
GeneReviews	RBBP8
HGNC	HGNC:9891
HPA	HPA039890 HPA052946
MalaCards	RBBP8
MIM	251255 604124 606744
neXtProt	NX_Q99708
OpenTargets	ENSG00000101773
Orphanet	313795 808
PharmGKB	PA34255
eggNOG	ENOG410IJ39 ENOG410ZSBE
GeneTree	ENSGT00530000063835
HOGENOM	HOG000293331
HOVERGEN	HBG057046
InParanoid	Q99708
KO	K20773
PhylomeDB	Q99708
TreeFam	TF106469
Reactome	[www.reactome.org/content/detail/R-HSA-5685938 R-HSA-5685938] [www.reactome.org/content/detail/R-HSA-5685939 R-HSA-5685939] [www.reactome.org/content/detail/R-HSA-5685942 R-HSA-5685942] [www.reactome.org/content/detail/R-HSA-5693554 R-HSA-5693554] [www.reactome.org/content/detail/R-HSA-5693568 R-HSA-5693568] [www.reactome.org/content/detail/R-HSA-5693579 R-HSA-5693579] [www.reactome.org/content/detail/R-HSA-5693607 R-HSA-5693607] [www.reactome.org/content/detail/R-HSA-5693616 R-HSA-5693616] [www.reactome.org/content/detail/R-HSA-6804756 R-HSA-6804756] [www.reactome.org/content/detail/R-HSA-69473 R-HSA-69473] [www.reactome.org/content/detail/R-HSA-912446 R-HSA-912446]
SIGNOR	Q99708
ChiTaRS	RBBP8
EvolutionaryTrace	Q99708
GeneWiki	RBBP8
GenomeRNAi	5932
PRO	PR:Q99708
Proteomes	UP000005640
Bgee	ENSG00000101773
CleanEx	HS_RBBP8
ExpressionAtlas	Q99708
Genevisible	Q99708
GO	GO:0005694 GO:0043231 GO:0005654 GO:0005634 GO:0017053 GO:0003684 GO:0001103 GO:0001106 GO:0000014 GO:0001835 GO:0000075 GO:0051301 GO:0000729 GO:0010792 GO:0006281 GO:0006260 GO:0000731 GO:0000724 GO:0000082 GO:0031572 GO:0051321 GO:0007067 GO:0006289 GO:1901796 GO:0006357 GO:0032355 GO:0000732
InterPro	IPR019518 IPR013882 IPR033594 IPR033316
PANTHER	PTHR15107 PTHR15107:SF6
Pfam	PF10482 PF08573

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0006289	nucleotide-excision repair	PMID:23144634^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0017053	transcriptional repressor complex	PMID:16287852^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:16287852^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	PMID:16287852^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96T58	F	Seeded From UniProt	complete
involved_in	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing	PMID:18716619^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing	PMID:19202191^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:18716619^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:20829486^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	PMID:18716619^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	PMID:19202191^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070336	flap-structured DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387514 PomBase:SPCC338.08	F	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387514 PomBase:SPCC338.08	C	Seeded From UniProt	complete
involved_in	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387514 UniProtKB:Q99708	P	Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387514 UniProtKB:Q99708	P	Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387514 PomBase:SPCC338.08	F	Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387514 PomBase:SPCC338.08	F	Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387514 UniProtKB:Q99708	F	Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387514 PomBase:SPCC338.08 UniProtKB:Q99708	P	Seeded From UniProt	complete
enables	GO:0000406	double-strand/single-strand DNA junction binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387514 PomBase:SPCC338.08	F	Seeded From UniProt	complete
enables	GO:0000403	Y-form DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387514 PomBase:SPCC338.08	F	Seeded From UniProt	complete
enables	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387514 UniProtKB:Q99708	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25558984^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99708	F	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P	Seeded From UniProt	complete
involved_in	GO:1903507	negative regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003714	P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B1WC58 ensembl:ENSRNOP00000017291	P	Seeded From UniProt	complete
involved_in	GO:0001835	blastocyst hatching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80YR6 ensembl:ENSMUSP00000111527	P	Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80YR6 ensembl:ENSMUSP00000111527	P	Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033594	P	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013882 InterPro:IPR033594	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033594	C	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013882	P	Seeded From UniProt	complete
involved_in	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033594	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:10764811^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:10764811^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10764811^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5684887 Reactome:R-HSA-5684882 Reactome:R-HSA-5684875 Reactome:R-HSA-5684140 Reactome:R-HSA-5684108 Reactome:R-HSA-5684096 Reactome:R-HSA-5684081 Reactome:R-HSA-9007625 Reactome:R-HSA-6799332 Reactome:R-HSA-5693620 Reactome:R-HSA-5693608 Reactome:R-HSA-5693593 Reactome:R-HSA-5693589 Reactome:R-HSA-5693584 Reactome:R-HSA-5693580 Reactome:R-HSA-5693564 Reactome:R-HSA-5693561 Reactome:R-HSA-5693542 Reactome:R-HSA-5693539 Reactome:R-HSA-5687675 Reactome:R-HSA-5687673 Reactome:R-HSA-5687664 Reactome:R-HSA-5687653 Reactome:R-HSA-5687640 Reactome:R-HSA-5687484 Reactome:R-HSA-5687465 Reactome:R-HSA-5687464 Reactome:R-HSA-5686657 Reactome:R-HSA-5686642 Reactome:R-HSA-5686483 Reactome:R-HSA-5686469 Reactome:R-HSA-5686440 Reactome:R-HSA-5686410 Reactome:R-HSA-5685994 Reactome:R-HSA-5685985 Reactome:R-HSA-5685953 Reactome:R-HSA-5685838 Reactome:R-HSA-5685341 Reactome:R-HSA-5685156 Reactome:R-HSA-5685011	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000729	DNA double-strand break processing	Reactome:R-HSA-5693608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	Reactome:R-HSA-5693538	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070317	negative regulation of G0 to G1 transition	Reactome:R-HSA-8953750	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	Reactome:R-HSA-5684887 Reactome:R-HSA-5684875	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
	GO:0070533	BRCA1-C complex	PMID:28132842^[9]	ECO:0000314			C	CtIP interacts with Brca1 to help promote the start of resection during NHEJ. Figure 2 shows slow DSB repair through CTIP function.	complete CACAO 12860
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0051321	meiotic cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0469	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Duquette, ML et al. (2012) CtIP is required to initiate replication-dependent interstrand crosslink repair. PLoS Genet. 8 e1003050 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Oswald, F et al. (2005) RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol. Cell. Biol. 25 10379-90 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Huertas, P et al. (2008) CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455 689-92 PubMed GONUTS page
↑ ^4.0 ^4.1 Huertas, P & Jackson, SP (2009) Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J. Biol. Chem. 284 9558-65 PubMed GONUTS page
↑ Kaidi, A et al. (2010) Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329 1348-53 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Davies, OR et al. (2015) CtIP tetramer assembly is required for DNA-end resection and repair. Nat. Struct. Mol. Biol. 22 150-157 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Yu, X & Baer, R (2000) Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. J. Biol. Chem. 275 18541-9 PubMed GONUTS page
↑ Biehs, R et al. (2017) DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination. Mol. Cell 65 671-684.e5 PubMed GONUTS page

[PMID:23144634-1] Duquette, ML et al. (2012) CtIP is required to initiate replication-dependent interstrand crosslink repair. PLoS Genet. 8 e1003050 PubMed GONUTS page

[PMID:16287852-2] 2.0 ^2.1 ^2.2 Oswald, F et al. (2005) RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol. Cell. Biol. 25 10379-90 PubMed GONUTS page

[PMID:18716619-3] 3.0 ^3.1 ^3.2 Huertas, P et al. (2008) CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455 689-92 PubMed GONUTS page

[PMID:19202191-4] 4.0 ^4.1 Huertas, P & Jackson, SP (2009) Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J. Biol. Chem. 284 9558-65 PubMed GONUTS page

[PMID:20829486-5] Kaidi, A et al. (2010) Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329 1348-53 PubMed GONUTS page

[PMID:21873635-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25558984-7] Davies, OR et al. (2015) CtIP tetramer assembly is required for DNA-end resection and repair. Nat. Struct. Mol. Biol. 22 150-157 PubMed GONUTS page

[PMID:10764811-8] 8.0 ^8.1 ^8.2 Yu, X & Baer, R (2000) Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. J. Biol. Chem. 275 18541-9 PubMed GONUTS page

[PMID:28132842-9] Biehs, R et al. (2017) DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination. Mol. Cell 65 671-684.e5 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

HUMAN:CTIP

Contents

Annotations

Notes

References

b

c

d

e

f

g

h

i

m

n

o

p

r

s

t

v

y

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools