HUMAN:CTGF

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CTGF (synonyms: CCN2, HCS24, IGFBP8)
Protein Name(s)	Connective tissue growth factor CCN family member 2 Hypertrophic chondrocyte-specific protein 24 Insulin-like growth factor-binding protein 8 IBP-8 IGF-binding protein 8 IGFBP-8
External Links
UniProt	P29279
EMBL	M92934 X78947 AY395801 AY550024 BT019794 BT019795 CR541759 AL354866 X92511 CH471051 CH471051 AF316366 AF316367 AF316368 U14750
CCDS	CCDS5151.1
PIR	A40551
RefSeq	NP_001892.1
UniGene	Hs.410037
ProteinModelPortal	P29279
SMR	P29279
BioGrid	107872
IntAct	P29279
MINT	MINT-1779737
STRING	9606.ENSP00000356954
PhosphoSite	P29279
DMDM	116241320
MaxQB	P29279
PaxDb	P29279
PRIDE	P29279
DNASU	1490
Ensembl	ENST00000367976
GeneID	1490
KEGG	hsa:1490
CTD	1490
GeneCards	GC06M132269
HGNC	HGNC:2500
HPA	CAB005123 HPA031074 HPA031075
MIM	121009
neXtProt	NX_P29279
Orphanet	220393 220402
PharmGKB	PA27003
eggNOG	NOG72934
GeneTree	ENSGT00760000119225
HOGENOM	HOG000231462
HOVERGEN	HBG000635
InParanoid	P29279
KO	K06827
OMA	TYRAKFC
OrthoDB	EOG7N8ZXB
PhylomeDB	P29279
TreeFam	TF326070
Reactome	REACT_116145 REACT_118713
ChiTaRS	CTGF
GeneWiki	CTGF
GenomeRNAi	1490
NextBio	6123
PRO	PR:P29279
Proteomes	UP000005640
Bgee	P29279
CleanEx	HS_CTGF
ExpressionAtlas	P29279
Genevestigator	P29279
GO	GO:0005938 GO:0005801 GO:0005829 GO:0005576 GO:0005615 GO:0005794 GO:0043231 GO:0048471 GO:0005886 GO:0005578 GO:0008201 GO:0005520 GO:0001525 GO:0001502 GO:0030154 GO:0016477 GO:0007160 GO:0044255 GO:0035988 GO:0060401 GO:0071897 GO:0008544 GO:0070278 GO:0008543 GO:0010467 GO:0007229 GO:0035556 GO:0030324 GO:0060548 GO:0010629 GO:0010260 GO:0001503 GO:0060452 GO:0050867 GO:0045597 GO:0008284 GO:0032967 GO:0043280 GO:0070374 GO:0070318 GO:0046330 GO:0001934 GO:0051496 GO:0072593 GO:0001558 GO:0032330 GO:0043200 GO:0034059 GO:0032355 GO:0070542 GO:0009749 GO:0051385 GO:0043434 GO:0009611 GO:0044281 GO:0001894 GO:0006367
InterPro	IPR006207 IPR006208 IPR009030 IPR000867 IPR012395 IPR017891 IPR000884 IPR001007
Pfam	PF00007 PF00219 PF00090 PF00093
PIRSF	PIRSF036495
SMART	SM00041 SM00121 SM00209 SM00214
SUPFAM	SSF57184 SSF82895
PROSITE	PS01185 PS01225 PS00222 PS51323 PS50092 PS01208 PS50184

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:28327460^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002570)	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:9927660^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23142-4	F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:20008146^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	PMID:20008146^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:20008146^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	PMID:20008146^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000142748 RGD:621392	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95537 PANTHER:PTN000142748	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95537 PANTHER:PTN000142748	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88613 PANTHER:PTN000142748 RGD:620763	P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88613 MGI:MGI:95537 PANTHER:PTN000142748 UniProtKB:P48745	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
involved_in	GO:0061448	connective tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
involved_in	GO:0035988	chondrocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
involved_in	GO:0032330	regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	C		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	F		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
involved_in	GO:0007160	cell-matrix adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	F		Seeded From UniProt	complete
involved_in	GO:0001894	tissue homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
involved_in	GO:0001502	cartilage condensation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29268 ensembl:ENSMUSP00000020171	P		Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0070318	positive regulation of G0 to G1 transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0070278	extracellular matrix constituent secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0060452	positive regulation of cardiac muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0060401	cytosolic calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0051385	response to mineralocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0050867	positive regulation of cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	C		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0034059	response to anoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	C		Seeded From UniProt	complete
part_of	GO:0005801	cis-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	C		Seeded From UniProt	complete
enables	GO:0001968	fibronectin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
enables	GO:0005520	insulin-like growth factor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000867	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000867	C		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	PMID:10809757^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008544	epidermis development	PMID:10809757^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10809757^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:10809757^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005520	insulin-like growth factor binding	PMID:9371786^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-2032785	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-1989766	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0237	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
↑ Perbal, B et al. (1999) The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. Proc. Natl. Acad. Sci. U.S.A. 96 869-74 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Kanno, Y et al. (2010) alpha2-antiplasmin is associated with the progression of fibrosis. Am. J. Pathol. 176 238-45 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Abraham, DJ et al. (2000) Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts. J. Biol. Chem. 275 15220-5 PubMed GONUTS page
↑ Kim, HS et al. (1997) Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily. Proc. Natl. Acad. Sci. U.S.A. 94 12981-6 PubMed GONUTS page

[PMID:28327460-1] Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page

[PMID:9927660-2] Perbal, B et al. (1999) The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. Proc. Natl. Acad. Sci. U.S.A. 96 869-74 PubMed GONUTS page

[PMID:20008146-3] 3.0 ^3.1 ^3.2 ^3.3 Kanno, Y et al. (2010) alpha2-antiplasmin is associated with the progression of fibrosis. Am. J. Pathol. 176 238-45 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10809757-5] 5.0 ^5.1 ^5.2 ^5.3 Abraham, DJ et al. (2000) Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts. J. Biol. Chem. 275 15220-5 PubMed GONUTS page

[PMID:9371786-6] Kim, HS et al. (1997) Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily. Proc. Natl. Acad. Sci. U.S.A. 94 12981-6 PubMed GONUTS page

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HUMAN:CTGF

Contents

Annotations

Notes

References

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