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HUMAN:CRTC2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CRTC2 (synonyms: TORC2)
Protein Name(s) CREB-regulated transcription coactivator 2

Transducer of regulated cAMP response element-binding protein 2 TORC-2 Transducer of CREB protein 2

External Links
UniProt Q53ET0
EMBL AY360172
AK223559
AL358472
BC028886
BC053562
CCDS CCDS30875.1
RefSeq NP_859066.1
UniGene Hs.406392
PDB 4HTM
PDBsum 4HTM
ProteinModelPortal Q53ET0
SMR Q53ET0
BioGrid 128308
DIP DIP-29950N
IntAct Q53ET0
MINT MINT-1631979
STRING 9606.ENSP00000305873
PhosphoSite Q53ET0
DMDM 167009135
MaxQB Q53ET0
PaxDb Q53ET0
PRIDE Q53ET0
Ensembl ENST00000368633
GeneID 200186
KEGG hsa:200186
UCSC uc021pab.1
CTD 200186
GeneCards GC01M153920
HGNC HGNC:27301
HPA HPA028454
HPA028465
MIM 608972
neXtProt NX_Q53ET0
PharmGKB PA142672073
eggNOG NOG74259
GeneTree ENSGT00390000010652
HOGENOM HOG000111980
HOVERGEN HBG058314
InParanoid Q53ET0
KO K16333
OMA HTLNHQN
OrthoDB EOG7MKW5P
PhylomeDB Q53ET0
TreeFam TF321571
ChiTaRS CRTC2
GeneWiki CRTC2
GenomeRNAi 200186
NextBio 89862
PRO PR:Q53ET0
Proteomes UP000005640
Bgee Q53ET0
CleanEx HS_CRTC2
ExpressionAtlas Q53ET0
Genevestigator Q53ET0
GO GO:0005737
GO:0070062
GO:0005634
GO:0008140
GO:0006094
GO:0042593
GO:0043970
GO:0032793
GO:0045944
GO:0051289
GO:0006351
GO:0016032
InterPro IPR024786
IPR024785
IPR024784
IPR024783
PANTHER PTHR13589
Pfam PF12886
PF12885
PF12884

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005515

protein binding

PMID:20675384[1]

ECO:0000021

UniProtKB:Q13526


F

FIGURE 1. Pin1 associates with CRTC2.

complete

GO:0045449

regulation of transcription

PMID:20675384[1]

ECO:0000315

P

Figure 5.

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0042593

glucose homeostasis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3U182

P

Seeded From UniProt

complete

involved_in

GO:0032793

positive regulation of CREB transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3U182

P

Seeded From UniProt

complete

involved_in

GO:0006094

gluconeogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3U182

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3U182

C

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1917711
MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040
UniProtKB:Q6UUV9

P

Seeded From UniProt

complete

involved_in

GO:0032793

positive regulation of CREB transcription factor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040

P

Seeded From UniProt

complete

enables

GO:0008140

cAMP response element binding protein binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001006040
UniProtKB:Q6UUV9
WB:WBGene00021237

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1917711
MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040
RGD:1308903
RGD:1589158
WB:WBGene00021237

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0036746
MGI:MGI:1917711
MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040
RGD:1308903
RGD:1589158
UniProtKB:Q6UUV9
WB:WBGene00021237

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042593

glucose homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3LRZ1
ensembl:ENSRNOP00000068813

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3LRZ1
ensembl:ENSRNOP00000068813

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3LRZ1
ensembl:ENSRNOP00000068813

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3LRZ1
ensembl:ENSRNOP00000068813

F

Seeded From UniProt

complete

involved_in

GO:1901998

toxin transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U182
ensembl:ENSMUSP00000029545

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U182
ensembl:ENSMUSP00000029545

P

Seeded From UniProt

complete

involved_in

GO:0043970

histone H3-K9 acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U182
ensembl:ENSMUSP00000029545

P

Seeded From UniProt

complete

involved_in

GO:0042593

glucose homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U182
ensembl:ENSMUSP00000029545

P

Seeded From UniProt

complete

involved_in

GO:0032793

positive regulation of CREB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U182
ensembl:ENSMUSP00000029545

P

Seeded From UniProt

complete

involved_in

GO:0006094

gluconeogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U182
ensembl:ENSMUSP00000029545

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U182
ensembl:ENSMUSP00000029545

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U182
ensembl:ENSMUSP00000029545

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024786

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024786

C

Seeded From UniProt

complete

enables

GO:0008140

cAMP response element binding protein binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024783

F

Seeded From UniProt

complete

involved_in

GO:0032793

positive regulation of CREB transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024786

P

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024783

P

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Nakatsu, Y et al. (2010) Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity. J. Biol. Chem. 285 33018-27 PubMed GONUTS page
  2. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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