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HUMAN:CRP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CRP (synonyms: PTX1)
Protein Name(s) C-reactive protein

C-reactive protein(1-205)

External Links
UniProt P02741
EMBL M11880
M11725
X56692
X56214
AF442818
AK289443
AF449713
AL445528
AL445528
CH471121
CH471121
CH471121
BC020766
BC125135
M35163
K00518
CCDS CCDS30911.1
PIR A24515
RefSeq NP_000558.2
UniGene Hs.709456
Hs.76452
PDB 1B09
1CRV
1GNH
1LJ7
3L2Y
3PVN
3PVO
PDBsum 1B09
1CRV
1GNH
1LJ7
3L2Y
3PVN
3PVO
ProteinModelPortal P02741
SMR P02741
BioGrid 107791
DIP DIP-39125N
IntAct P02741
MINT MINT-1206167
STRING 9606.ENSP00000255030
DrugBank DB05278
PhosphoSite P02741
DMDM 117486
DOSAC-COBS-2DPAGE P02741
SWISS-2DPAGE P02741
PaxDb P02741
PeptideAtlas P02741
PRIDE P02741
Ensembl ENST00000255030
ENST00000368112
GeneID 1401
KEGG hsa:1401
UCSC uc001ftw.3
uc001ftx.1
CTD 1401
GeneCards GC01M159682
H-InvDB HIX0028720
HGNC HGNC:2367
HPA CAB005036
HPA027367
HPA027396
MIM 123260
neXtProt NX_P02741
PharmGKB PA120
eggNOG NOG113288
GeneTree ENSGT00760000119128
HOGENOM HOG000247043
HOVERGEN HBG005405
InParanoid P02741
KO K16143
OMA TKPLKAF
OrthoDB EOG71RXMB
PhylomeDB P02741
TreeFam TF330208
Reactome REACT_7956
ChiTaRS CRP
EvolutionaryTrace P02741
GeneWiki C-reactive_protein
GenomeRNAi 1401
NextBio 5737
PRO PR:P02741
Proteomes UP000005640
Bgee P02741
CleanEx HS_CRP
ExpressionAtlas P02741
Genevestigator P02741
GO GO:0005576
GO:0005615
GO:0070062
GO:0030175
GO:0030426
GO:0005509
GO:0015485
GO:0033265
GO:0001849
GO:0030169
GO:0050750
GO:0006953
GO:0007568
GO:0071277
GO:0006958
GO:0050830
GO:0006954
GO:0010888
GO:0010745
GO:0045908
GO:0008228
GO:1900006
GO:0010628
GO:0032930
GO:0051258
GO:2000482
GO:0045471
GO:0001666
GO:0010288
GO:0042060
Gene3D 2.60.120.200
InterPro IPR013320
IPR001759
Pfam PF00354
PRINTS PR00895
SMART SM00159
SUPFAM SSF49899
PROSITE PS00289

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032945

negative regulation of mononuclear cell proliferation

PMID:29202702[1]

ECO:0000314

P

“CRP decreased the numbers of Mono Mac 6 cells at 24 and 48 h (Fig. 1d, e).”

Organism: Human

complete
CACAO 13073

part_of

GO:0005615

extracellular space

PMID:21323571[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001977)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:24141169[3]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P79335)

Seeded From UniProt

complete

involved_in

GO:0032930

positive regulation of superoxide anion generation

PMID:24141169[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097756

negative regulation of blood vessel diameter

PMID:24141169[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q9TTK7)|has_regulation_target:(UniProtKB:Q9TTK7)

Seeded From UniProt

complete

involved_in

GO:0097756

negative regulation of blood vessel diameter

PMID:24141169[3]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000115)

Seeded From UniProt

complete

enables

GO:0050750

low-density lipoprotein particle receptor binding

PMID:24141169[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9TTK7

F

Seeded From UniProt

complete

involved_in

GO:2000482

regulation of interleukin-8 secretion

PMID:21037097[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|enables

GO:0046790

virion binding

PMID:23544079[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:23544079[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001977)

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:23544079[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001849

complement component C1q binding

PMID:23544079[5]

ECO:0000314

direct assay evidence used in manual assertion

F

activated_by:(CHEBI:29108)

Seeded From UniProt

complete

enables

GO:0030169

low-density lipoprotein particle binding

PMID:18322245[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010888

negative regulation of lipid storage

PMID:18322245[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010745

negative regulation of macrophage derived foam cell differentiation

PMID:18322245[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:14718574[7]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000444388
UniProtKB:P02743

P

Seeded From UniProt

complete

enables

GO:0030169

low-density lipoprotein particle binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000444388
RGD:2411
UniProtKB:P02741

F

Seeded From UniProt

complete

involved_in

GO:0006958

complement activation, classical pathway

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000444388
RGD:2411

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000444388
RGD:2411
UniProtKB:P02741
UniProtKB:P02743

C

Seeded From UniProt

complete

enables

GO:0001849

complement component C1q binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000444388
UniProtKB:P02741
UniProtKB:P02743

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16642000[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02741

F

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:10408362[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:2477488[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0033265

choline binding

PMID:2477488[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0008228

opsonization

PMID:2477488[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006953

acute-phase response

PMID:2477488[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0006953

acute-phase response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0011

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Chen, W et al. (2017) C-reactive protein (CRP) but not the related pentraxins serum amyloid P and PTX3 inhibits the proliferation and induces apoptosis of the leukemia cell line Mono Mac 6. BMC Immunol. 18 47 PubMed GONUTS page
  2. ↑ Khan, DA et al. (2011) Pro/anti-inflammatory cytokines in the pathogenesis of premature coronary artery disease. J. Interferon Cytokine Res. 31 561-7 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Hein, TW et al. (2014) Selective activation of lectin-like oxidized low-density lipoprotein receptor-1 mediates C-reactive protein-evoked endothelial vasodilator dysfunction in coronary arterioles. Circ. Res. 114 92-100 PubMed GONUTS page
  4. ↑ Zhang, J et al. (2010) Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense. J. Immunol. 185 6899-910 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Job, ER et al. (2013) Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses. PLoS ONE 8 e59623 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Singh, SK et al. (2008) C-reactive protein-bound enzymatically modified low-density lipoprotein does not transform macrophages into foam cells. J. Immunol. 180 4316-22 PubMed GONUTS page
  7. ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  9. ↑ Pepys, MB et al. (2006) Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 440 1217-21 PubMed GONUTS page
  10. ↑ Mold, C et al. (1999) Regulation of complement activation by C-reactive protein. Immunopharmacology 42 23-30 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 11.3 Wright, SD et al. (1989) Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J. Exp. Med. 170 1231-41 PubMed GONUTS page
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