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HUMAN:CRCM
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MCC | |
| Protein Name(s) | Colorectal mutant cancer protein
Protein MCC | |
| External Links | ||
| UniProt | P23508 | |
| EMBL | M62397 AC008536 AC010431 AC079465 AC093208 AC106750 AC126917 CH471086 CH471086 BC009279 BC018919 AK128596 | |
| CCDS | CCDS4111.1 CCDS43351.1 | |
| PIR | A38434 | |
| RefSeq | NP_001078846.1 NP_002378.1 | |
| UniGene | Hs.593171 | |
| ProteinModelPortal | P23508 | |
| BioGrid | 110333 | |
| DIP | DIP-27599N | |
| IntAct | P23508 | |
| MINT | MINT-1161194 | |
| STRING | 9606.ENSP00000386227 | |
| PhosphoSite | P23508 | |
| DMDM | 317373352 | |
| MaxQB | P23508 | |
| PaxDb | P23508 | |
| PRIDE | P23508 | |
| DNASU | 4163 | |
| Ensembl | ENST00000302475 ENST00000408903 | |
| GeneID | 4163 | |
| KEGG | hsa:4163 | |
| UCSC | uc003kqj.4 uc003kql.4 | |
| CTD | 4163 | |
| GeneCards | GC05M112388 | |
| HGNC | HGNC:6935 | |
| HPA | HPA037390 HPA037391 | |
| MIM | 159350 | |
| neXtProt | NX_P23508 | |
| PharmGKB | PA30679 | |
| eggNOG | NOG122105 | |
| GeneTree | ENSGT00530000063974 | |
| HOGENOM | HOG000111967 | |
| HOVERGEN | HBG004762 | |
| InParanoid | P23508 | |
| OMA | TGCSVQP | |
| OrthoDB | EOG7B05C9 | |
| PhylomeDB | P23508 | |
| TreeFam | TF333056 | |
| SignaLink | P23508 | |
| ChiTaRS | MCC | |
| GeneWiki | MCC_(gene) | |
| GenomeRNAi | 4163 | |
| NextBio | 16402 | |
| PRO | PR:P23508 | |
| Proteomes | UP000005640 | |
| Bgee | P23508 | |
| CleanEx | HS_MCC | |
| ExpressionAtlas | P23508 | |
| Genevestigator | P23508 | |
| GO | GO:0005737 GO:0030027 GO:0005634 GO:0005886 GO:0004872 GO:0090090 GO:0010633 GO:0050680 GO:0007165 GO:0016055 | |
| InterPro | IPR019536 | |
| Pfam | PF10506 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Figure 1c showed Western Blot Analysis was used to confirm localization of the MCC protein to the cytoplasm. |
complete | |||||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 1c showed the use of Western Blot Analysis to confirm MCC protein localization in the nucleus of cells. |
complete | |||||
| GO:0051726 |
regulation of cell cycle |
ECO:0000314 |
P |
Figure 4C and 4D shows that MCC regulates the cell cycle by suppressing the DNA-binding activity of β-catenin/TCF/LEF in the nucleus through Western Blot Analysis. This is also confirmed in the section of the text "MCC interacts with β-catenin, blocks β-catenin/TCF/LEF DNA binding, and can affect endogenous β-catenin localization/levels". |
complete | |||||
| GO:0045184 |
establishment of protein localization |
ECO:0000314 |
P |
The section of the text "MCC interacts with β-catenin, blocks β-catenin/TCF/LEF DNA binding, and can affect endogenous β-catenin localization/levels" confirms that MCC relocalizes the β-catenin to the cytoplasm. The results are further confirmed through Western Blot Analysis in Figure 4. |
complete | |||||
| GO:0030308 |
negative regulation of cell growth |
ECO:0000314 |
P |
Immunofluorescence was used and confirmed in Figure 6A/B to show that MCC is responsible for the suppression of basal cell growth. |
complete | |||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045184 |
establishment of protein localization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050680 |
negative regulation of epithelial cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010633 |
negative regulation of epithelial cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Fukuyama, R et al. (2008) Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription. Oncogene 27 6044-55 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Pangon, L et al. (2015) MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm. Int. J. Cancer 136 55-64 PubMed GONUTS page
- ↑ 3.0 3.1 Arnaud, C et al. (2009) MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells. FEBS Lett. 583 2326-32 PubMed GONUTS page
- ↑ 4.0 4.1 Kinzler, KW et al. (1991) Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science 251 1366-70 PubMed GONUTS page
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