GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:CP24A

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CYP24A1 (synonyms: CYP24)
Protein Name(s) 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

24-OHase Vitamin D(3) 24-hydroxylase Cytochrome P450 24A1 Cytochrome P450-CC24

External Links
UniProt Q07973
EMBL L13286
AY858838
AL138805
AL138805
BC109083
BC109084
U60669
S67623
CCDS CCDS33491.1
CCDS46616.1
PIR A47436
I55488
RefSeq NP_000773.2
NP_001122387.1
XP_005260361.1
UniGene Hs.89663
ProteinModelPortal Q07973
SMR Q07973
BioGrid 107963
IntAct Q07973
MINT MINT-6773699
STRING 9606.ENSP00000216862
BindingDB Q07973
ChEMBL CHEMBL4521
DrugBank DB00146
DB02300
DB00136
DB01285
DB00153
DB00910
PhosphoSite Q07973
DMDM 19862747
MaxQB Q07973
PaxDb Q07973
PRIDE Q07973
Ensembl ENST00000216862
ENST00000395954
ENST00000395955
GeneID 1591
KEGG hsa:1591
UCSC uc002xwv.2
uc002xww.2
CTD 1591
GeneCards GC20M052769
HGNC HGNC:2602
HPA HPA022261
MIM 126065
143880
neXtProt NX_Q07973
Orphanet 300547
PharmGKB PA27097
eggNOG COG2124
GeneTree ENSGT00760000119243
HOGENOM HOG000276540
HOVERGEN HBG099053
InParanoid Q07973
KO K07436
OMA MGRIELM
OrthoDB EOG7ZGX4B
PhylomeDB Q07973
TreeFam TF105094
BioCyc MetaCyc:HS00395-MONOMER
Reactome REACT_13450
REACT_13523
SABIO-RK Q07973
ChiTaRS CYP24A1
GeneWiki CYP24A1
GenomeRNAi 1591
NextBio 6538
PRO PR:Q07973
Proteomes UP000005640
Bgee Q07973
CleanEx HS_CYP24A1
Genevestigator Q07973
GO GO:0005743
GO:0030342
GO:0008403
GO:0020037
GO:0005506
GO:0016491
GO:0001649
GO:0055114
GO:0033280
GO:0044281
GO:0008202
GO:0042369
GO:0042359
GO:0070561
GO:0006766
GO:0006805
Gene3D 1.10.630.10
InterPro IPR001128
IPR017972
IPR002401
Pfam PF00067
PRINTS PR00463
PR00385
SUPFAM SSF48264
PROSITE PS00086

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0070561

vitamin D receptor signaling pathway

PMID:16720713[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042369

vitamin D catabolic process

PMID:16720713[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033280

response to vitamin D

PMID:16720713[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

PMID:17023519[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

PMID:8506296[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030342

1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity

PMID:8506296[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

PMID:7632726[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042359

vitamin D metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q09128
ensembl:ENSRNOP00000043298

P

Seeded From UniProt

complete

enables

GO:0008403

25-hydroxycholecalciferol-24-hydroxylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q09128
ensembl:ENSRNOP00000043298

F

Seeded From UniProt

complete

involved_in

GO:0042359

vitamin D metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q64441
ensembl:ENSMUSP00000047954

P

Seeded From UniProt

complete

enables

GO:0008403

25-hydroxycholecalciferol-24-hydroxylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q64441
ensembl:ENSMUSP00000047954

F

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001128
InterPro:IPR002401
InterPro:IPR036396

F

Seeded From UniProt

complete

enables

GO:0016705

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001128
InterPro:IPR002401
InterPro:IPR017972
InterPro:IPR036396

F

Seeded From UniProt

complete

enables

GO:0020037

heme binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001128
InterPro:IPR002401
InterPro:IPR036396

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001128
InterPro:IPR002401
InterPro:IPR017972
InterPro:IPR036396

P

Seeded From UniProt

complete

enables

GO:0020037

heme binding

PMID:8506296[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042359

vitamin D metabolic process

Reactome:R-HSA-196791

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030342

1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity

Reactome:R-HSA-211950
Reactome:R-HSA-209765

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

involved_in

GO:0006766

vitamin metabolic process

Reactome:R-HSA-211916

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

Reactome:R-HSA-211950
Reactome:R-HSA-209765

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0503

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Viganò, P et al. (2006) Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J. Mol. Endocrinol. 36 415-24 PubMed GONUTS page
  2. ↑ van Driel, M et al. (2006) Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells. FASEB J. 20 2417-9 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Chen, KS et al. (1993) Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA. Proc. Natl. Acad. Sci. U.S.A. 90 4543-7 PubMed GONUTS page
  4. ↑ Chen, KS & DeLuca, HF (1995) Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements. Biochim. Biophys. Acta 1263 1-9 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:CP24A&oldid=5933852"