HUMAN:CP1A1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CYP1A1
Protein Name(s)	Cytochrome P450 1A1 CYPIA1 Cytochrome P450 form 6 Cytochrome P450-C Cytochrome P450-P1
External Links
UniProt	P04798
EMBL	X02612 K03191 X04300 AF253322 AM233518 AM233519 AM233520 AK223113 AC091230 BC023019 M12079 AF040259
CCDS	CCDS10268.1
PIR	A24797
RefSeq	NP_000490.1 XP_005254242.1
UniGene	Hs.72912
PDB	4I8V
PDBsum	4I8V
ProteinModelPortal	P04798
SMR	P04798
BioGrid	107923
STRING	9606.ENSP00000369050
BindingDB	P04798
ChEMBL	CHEMBL2231
DrugBank	DB00316 DB00518 DB01118 DB00381 DB00613 DB01169 DB00972 DB06770 DB01393 DB00188 DB00201 DB01136 DB00608 DB00356 DB00169 DB00568 DB01407 DB01013 DB00636 DB00882 DB00575 DB00363 DB00851 DB06292 DB01254 DB00694 DB04840 DB01234 DB00633 DB00586 DB00804 DB00470 DB00530 DB00783 DB00655 DB00898 DB04841 DB00693 DB00499 DB01095 DB00176 DB00317 DB00889 DB00502 DB01064 DB01167 DB01026 DB00448 DB04871 DB00643 DB01065 DB00170 DB00553 DB00184 DB01115 DB00325 DB01059 DB00338 DB01092 DB00526 DB00738 DB01174 DB00457 DB01087 DB00396 DB00818 DB00571 DB00165 DB00908 DB00468 DB01129 DB00740 DB00203 DB00428 DB00605 DB00675 DB00624 DB01041 DB00277 DB00730 DB00208 DB00539 DB00755 DB00162 DB00682
PhosphoSite	P04798
DMDM	117139
MaxQB	P04798
PaxDb	P04798
PRIDE	P04798
DNASU	1543
Ensembl	ENST00000379727 ENST00000395048 ENST00000562201 ENST00000564596 ENST00000567032 ENST00000569630
GeneID	1543
KEGG	hsa:1543
UCSC	uc002ayp.4
CTD	1543
GeneCards	GC15M075011
HGNC	HGNC:2595
HPA	CAB018654
MIM	108330
neXtProt	NX_P04798
PharmGKB	PA27092
eggNOG	COG2124
GeneTree	ENSGT00760000118992
HOGENOM	HOG000036991
HOVERGEN	HBG106944
InParanoid	P04798
KO	K07408
OMA	KHACCEH
OrthoDB	EOG7RBZ85
PhylomeDB	P04798
TreeFam	TF105095
Reactome	REACT_116145 REACT_13543 REACT_150134 REACT_150417
SABIO-RK	P04798
ChiTaRS	CYP1A1
GeneWiki	Cytochrome_P450,_family_1,_member_A1
GenomeRNAi	1543
NextBio	35461723
PRO	PR:P04798
Proteomes	UP000005640
Bgee	P04798
CleanEx	HS_CYP1A1
ExpressionAtlas	P04798
Genevestigator	P04798
GO	GO:0005789 GO:0005739 GO:0070330 GO:0032451 GO:0016711 GO:0020037 GO:0005506 GO:0016491 GO:0016679 GO:0019825 GO:0008395 GO:0070576 GO:0042904 GO:0007568 GO:0009308 GO:0019369 GO:0043010 GO:0008283 GO:0044255 GO:0071407 GO:0009804 GO:0019341 GO:0048565 GO:0017144 GO:0009792 GO:0019373 GO:0009812 GO:0070365 GO:0050665 GO:0017143 GO:0060137 GO:0097267 GO:0055114 GO:0006778 GO:1900087 GO:0046677 GO:0046685 GO:0042493 GO:0032094 GO:0009635 GO:0055093 GO:0001666 GO:0035902 GO:0010041 GO:0032496 GO:0009624 GO:0009615 GO:0033189 GO:0009611 GO:0044281 GO:0042359 GO:0006805
Gene3D	1.10.630.10
InterPro	IPR001128 IPR017972 IPR002401 IPR008066
Pfam	PF00067
PRINTS	PR00463 PR01683 PR00385
SUPFAM	SSF48264
PROSITE	PS00086

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
NOT	GO:0070995	NADPH oxidation	PMID:22123124^[1]	ECO:0000315			P		Table 1. NADPH oxidation wild type compared to mutant	complete CACAO 3498
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00185	C		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00185	F		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00185	F		Seeded From UniProt	complete
enables	GO:0101020	estrogen 16-alpha-hydroxylase activity	PMID:14559847^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:17263) part_of:(GO:0002933) part_of:(GO:0008202)\|has_direct_input(CHEBI:16469) part_of:(GO:0002933) part_of:(GO:0008202)	Seeded From UniProt	complete
involved_in	GO:0002933	lipid hydroxylation	PMID:14559847^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0008202)	Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	PMID:14559847^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070576	vitamin D 24-hydroxylase activity	PMID:15546903^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	PMID:19219744^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042359	vitamin D metabolic process	PMID:15546903^[3]	ECO:0000305	curator inference used in manual assertion	GO:0070576	P		Seeded From UniProt	complete
involved_in	GO:0017144	drug metabolic process	PMID:19219744^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	PMID:19219744^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001210461 RGD:2458 RGD:2459 UniProtKB:P05177	C		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88588 PANTHER:PTN001210461 RGD:2458 RGD:2459 UniProtKB:P05177	F		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	PMID:23275542^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070988	demethylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0032451	P		Seeded From UniProt	complete
involved_in	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0070365	hepatocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0060137	maternal process involved in parturition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0055093	response to hyperoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	F		Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0046685	response to arsenic-containing substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	C		Seeded From UniProt	complete
involved_in	GO:0043010	camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0042904	9-cis-retinoic acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0035902	response to immobilization stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0032502	developmental process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
enables	GO:0032451	demethylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	F		Seeded From UniProt	complete
involved_in	GO:0032094	response to food	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	F		Seeded From UniProt	complete
involved_in	GO:0019341	dibenzo-p-dioxin catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0018894	dibenzo-p-dioxin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0017143	insecticide metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
enables	GO:0016711	flavonoid 3'-monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	F		Seeded From UniProt	complete
enables	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0010041	response to iron(III) ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0009812	flavonoid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0009804	coumarin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0009635	response to herbicide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0009624	response to nematode	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
enables	GO:0008395	steroid hydroxylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	F		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0006778	porphyrin-containing compound metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	C		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	F		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00185 ensembl:ENSRNOP00000026473	P		Seeded From UniProt	complete
involved_in	GO:0050665	hydrogen peroxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00184 ensembl:ENSMUSP00000150277	P		Seeded From UniProt	complete
involved_in	GO:0046483	heterocycle metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00184 ensembl:ENSMUSP00000150277	P		Seeded From UniProt	complete
enables	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00184 ensembl:ENSMUSP00000150277	F		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00184 ensembl:ENSMUSP00000150277	P		Seeded From UniProt	complete
involved_in	GO:0009404	toxin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00184 ensembl:ENSMUSP00000150277	P		Seeded From UniProt	complete
involved_in	GO:0009308	amine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00184 ensembl:ENSMUSP00000150277	P		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00184 ensembl:ENSMUSP00000150277	F		Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002401 InterPro:IPR008066 InterPro:IPR036396	F		Seeded From UniProt	complete
enables	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002401 InterPro:IPR017972 InterPro:IPR036396	F		Seeded From UniProt	complete
enables	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008066	F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002401 InterPro:IPR008066 InterPro:IPR036396	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002401 InterPro:IPR008066 InterPro:IPR017972 InterPro:IPR036396	P		Seeded From UniProt	complete
enables	GO:0070330	aromatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.14.1	F		Seeded From UniProt	complete
enables	GO:0019825	oxygen binding	PMID:1691986^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097267	omega-hydroxylase P450 pathway	Reactome:R-HSA-2142816	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042759	long-chain fatty acid biosynthetic process	Reactome:R-HSA-9018681	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019373	epoxygenase P450 pathway	Reactome:R-HSA-2142670	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	Reactome:R-HSA-400206	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009692	ethylene metabolic process	Reactome:R-HSA-76472	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-9037761 Reactome:R-HSA-76472 Reactome:R-HSA-2161940 Reactome:R-HSA-2161899 Reactome:R-HSA-2161890 Reactome:R-HSA-2161814 Reactome:R-HSA-2161795 Reactome:R-HSA-1989764	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	Reactome:R-HSA-76472	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0503	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C		Seeded From UniProt	complete
part_of	GO:0031090	organelle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0165	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Niwa, T et al. (2012) Effect of histidine-tag and R457H and E580Q mutations on catalytic activity of recombinant human cytochrome P450 oxidoreductase. Drug Metab. Pharmacokinet. 27 150-4 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Lee, AJ et al. (2003) Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol. Cancer Res. 63 6532-6 PubMed GONUTS page
↑ ^3.0 ^3.1 Gupta, RP et al. (2005) CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis. J. Clin. Endocrinol. Metab. 90 1210-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Laine, JE et al. (2009) Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica 39 11-21 PubMed GONUTS page
↑ ^5.0 ^5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ MacPherson, L et al. (2013) 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acids Res. 41 1604-21 PubMed GONUTS page
↑ Kawajiri, K et al. (1990) Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene. FEBS Lett. 263 131-3 PubMed GONUTS page

[PMID:22123124-1] Niwa, T et al. (2012) Effect of histidine-tag and R457H and E580Q mutations on catalytic activity of recombinant human cytochrome P450 oxidoreductase. Drug Metab. Pharmacokinet. 27 150-4 PubMed GONUTS page

[PMID:14559847-2] 2.0 ^2.1 ^2.2 Lee, AJ et al. (2003) Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol. Cancer Res. 63 6532-6 PubMed GONUTS page

[PMID:15546903-3] 3.0 ^3.1 Gupta, RP et al. (2005) CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis. J. Clin. Endocrinol. Metab. 90 1210-9 PubMed GONUTS page

[PMID:19219744-4] 4.0 ^4.1 ^4.2 Laine, JE et al. (2009) Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica 39 11-21 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23275542-6] MacPherson, L et al. (2013) 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acids Res. 41 1604-21 PubMed GONUTS page

[PMID:1691986-7] Kawajiri, K et al. (1990) Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene. FEBS Lett. 263 131-3 PubMed GONUTS page

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