HUMAN:CP110

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CCP110 (synonyms: CEP110, CP110, KIAA0419)
Protein Name(s)	Centriolar coiled-coil protein of 110 kDa Centrosomal protein of 110 kDa CP110 Cep110
External Links
UniProt	O43303
EMBL	AB007879 CR749255 AC003108 AC012621 BC036654
CCDS	CCDS10579.1 CCDS55992.1
PIR	T01372
RefSeq	NP_001185951.1 NP_055526.3 XP_005255776.1 XP_005255778.1
UniGene	Hs.279912
ProteinModelPortal	O43303
BioGrid	115087
DIP	DIP-39892N
IntAct	O43303
MINT	MINT-7994609
PhosphoSite	O43303
MaxQB	O43303
PaxDb	O43303
PRIDE	O43303
DNASU	9738
Ensembl	ENST00000381396 ENST00000396208 ENST00000396212
GeneID	9738
KEGG	hsa:9738
UCSC	uc002dgk.4 uc002dgl.4
CTD	9738
GeneCards	GC16P019536
HGNC	HGNC:24342
HPA	HPA039402
MIM	609544
neXtProt	NX_O43303
eggNOG	NOG82086
GeneTree	ENSGT00390000004090
HOVERGEN	HBG050873
InParanoid	O43303
KO	K16453
OMA	FYLWGSS
OrthoDB	EOG7SV0XP
PhylomeDB	O43303
TreeFam	TF332788
Reactome	REACT_15296 REACT_15364 REACT_15451 REACT_160315
ChiTaRS	CCP110
GeneWiki	CCP110
GenomeRNAi	9738
NextBio	36648
PRO	PR:O43303
Proteomes	UP000005640
Bgee	O43303
CleanEx	HS_CEP110
ExpressionAtlas	O43303
Genevestigator	O43303
GO	GO:0005814 GO:0005813 GO:0005829 GO:0043234 GO:0030030 GO:0007099 GO:0051298 GO:0000086 GO:0000278 GO:0032465

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005813	centrosome	PMID:12361598^[1]	ECO:0000314			C	Figure 5	complete CACAO 6986
	GO:0051298	centrosome duplication	PMID:12361598^[1]	ECO:0000315			P	Figure 6	complete CACAO 6987
involved_in	GO:0045724	positive regulation of cilium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TSH4	P	Seeded From UniProt	complete
involved_in	GO:0032053	ciliary basal body organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TSH4	P	Seeded From UniProt	complete
involved_in	GO:1902018	negative regulation of cilium assembly	PMID:17719545^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051298	centrosome duplication	PMID:12361598^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:12361598^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051298	centrosome duplication	PMID:23486064^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051298	centrosome duplication	PMID:16760425^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051298	centrosome duplication	PMID:20596027^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	PMID:16760425^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007099	centriole replication	PMID:17681131^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007099	centriole replication	PMID:16244668^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:20596027^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:17681131^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21399614^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:16760425^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:24421332^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:22684256^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1902018	negative regulation of cilium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TSH4 ensembl:ENSMUSP00000102167	P	Seeded From UniProt	complete
involved_in	GO:0045724	positive regulation of cilium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TSH4 ensembl:ENSMUSP00000102167	P	Seeded From UniProt	complete
involved_in	GO:0032053	ciliary basal body organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TSH4 ensembl:ENSMUSP00000102167	P	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TSH4 ensembl:ENSMUSP00000102167	C	Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033207	C	Seeded From UniProt	complete
involved_in	GO:0007099	centriole replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033207	P	Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033207	P	Seeded From UniProt	complete
involved_in	GO:0051298	centrosome duplication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033207	P	Seeded From UniProt	complete
involved_in	GO:0097711	ciliary basal body-plasma membrane docking	Reactome:R-HSA-5620912	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010389	regulation of G2/M transition of mitotic cell cycle	Reactome:R-HSA-8854518	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8853419 Reactome:R-HSA-8853405 Reactome:R-HSA-5696945 Reactome:R-HSA-5626699 Reactome:R-HSA-5626228 Reactome:R-HSA-5626227 Reactome:R-HSA-5626223 Reactome:R-HSA-5626220 Reactome:R-HSA-380508 Reactome:R-HSA-380455 Reactome:R-HSA-380316 Reactome:R-HSA-380311 Reactome:R-HSA-380303 Reactome:R-HSA-380294 Reactome:R-HSA-380283 Reactome:R-HSA-380272 Reactome:R-HSA-3000319 Reactome:R-HSA-3000310 Reactome:R-HSA-2574845 Reactome:R-HSA-2574840	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	Reactome:R-HSA-69275	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0970	P	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969	C	Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0046	C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Chen, Z et al. (2002) CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev. Cell 3 339-50 PubMed GONUTS page
↑ Spektor, A et al. (2007) Cep97 and CP110 suppress a cilia assembly program. Cell 130 678-90 PubMed GONUTS page
↑ Li, J et al. (2013) USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. Nature 495 255-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Tsang, WY et al. (2006) CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. Mol. Biol. Cell 17 3423-34 PubMed GONUTS page
↑ ^5.0 ^5.1 D'Angiolella, V et al. (2010) SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature 466 138-42 PubMed GONUTS page
↑ ^6.0 ^6.1 Kleylein-Sohn, J et al. (2007) Plk4-induced centriole biogenesis in human cells. Dev. Cell 13 190-202 PubMed GONUTS page
↑ Habedanck, R et al. (2005) The Polo kinase Plk4 functions in centriole duplication. Nat. Cell Biol. 7 1140-6 PubMed GONUTS page
↑ Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
↑ Kobayashi, T et al. (2014) The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. J. Cell Biol. 204 215-29 PubMed GONUTS page
↑ Cao, J et al. (2012) miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat. Cell Biol. 14 697-706 PubMed GONUTS page

[PMID:12361598-1] 1.0 ^1.1 ^1.2 ^1.3 Chen, Z et al. (2002) CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev. Cell 3 339-50 PubMed GONUTS page

[PMID:17719545-2] Spektor, A et al. (2007) Cep97 and CP110 suppress a cilia assembly program. Cell 130 678-90 PubMed GONUTS page

[PMID:23486064-3] Li, J et al. (2013) USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. Nature 495 255-9 PubMed GONUTS page

[PMID:16760425-4] 4.0 ^4.1 ^4.2 Tsang, WY et al. (2006) CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. Mol. Biol. Cell 17 3423-34 PubMed GONUTS page

[PMID:20596027-5] 5.0 ^5.1 D'Angiolella, V et al. (2010) SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature 466 138-42 PubMed GONUTS page

[PMID:17681131-6] 6.0 ^6.1 Kleylein-Sohn, J et al. (2007) Plk4-induced centriole biogenesis in human cells. Dev. Cell 13 190-202 PubMed GONUTS page

[PMID:16244668-7] Habedanck, R et al. (2005) The Polo kinase Plk4 functions in centriole duplication. Nat. Cell Biol. 7 1140-6 PubMed GONUTS page

[PMID:21399614-8] Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page

[PMID:24421332-9] Kobayashi, T et al. (2014) The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. J. Cell Biol. 204 215-29 PubMed GONUTS page

[PMID:22684256-10] Cao, J et al. (2012) miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat. Cell Biol. 14 697-706 PubMed GONUTS page

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HUMAN:CP110

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