HUMAN:COMT

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	COMT
Protein Name(s)	Catechol O-methyltransferase
External Links
UniProt	P21964
EMBL	M65212 M65213 M58525 Z26491 FJ224345 AK290440 CR456422 CR456997 AY341246 AC000080 AC000090 AC005663 CH471176 BC000419 BC005867 BC011935 BC100018
CCDS	CCDS13770.1 CCDS46663.1
PIR	I37256
RefSeq	NP_000745.1 NP_001128633.1 NP_001128634.1 NP_009294.1 XP_005261286.1
UniGene	Hs.370408 Hs.713616
PDB	3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK
PDBsum	3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK
ProteinModelPortal	P21964
SMR	P21964
BioGrid	107707
IntAct	P21964
MINT	MINT-4529967
STRING	9606.ENSP00000354511
BindingDB	P21964
ChEMBL	CHEMBL2023
DrugBank	DB00286 DB00255 DB00841 DB00988 DB00494 DB00968 DB01141 DB00118 DB01420 DB00323
GuidetoPHARMACOLOGY	2472
PhosphoSite	P21964
DMDM	116907
REPRODUCTION-2DPAGE	IPI00375513
MaxQB	P21964
PaxDb	P21964
PRIDE	P21964
DNASU	1312
Ensembl	ENST00000361682 ENST00000403710 ENST00000406520 ENST00000407537 ENST00000449653
GeneID	1312
KEGG	hsa:1312
UCSC	uc002zqu.3
CTD	1312
GeneCards	GC22P019929
HGNC	HGNC:2228
HPA	CAB011233 HPA001169
MIM	103780 116790
neXtProt	NX_P21964
Orphanet	567 240863 3140 240999
PharmGKB	PA117
eggNOG	COG4122
GeneTree	ENSGT00390000011316
HOGENOM	HOG000046392
HOVERGEN	HBG005376
InParanoid	P21964
KO	K00545
OMA	CTHYSSY
OrthoDB	EOG7PZRZJ
PhylomeDB	P21964
TreeFam	TF329140
BioCyc	MetaCyc:HS01791-MONOMER
BRENDA	2.1.1.6
Reactome	REACT_15511 REACT_15548 REACT_6946
ChiTaRS	COMT
EvolutionaryTrace	P21964
GeneWiki	Catechol-O-methyl_transferase
GenomeRNAi	1312
NextBio	5365
PRO	PR:P21964
Proteomes	UP000005640
Bgee	P21964
CleanEx	HS_COMT
ExpressionAtlas	P21964
Genevestigator	P21964
GO	GO:0030424 GO:0044297 GO:0005829 GO:0043197 GO:0070062 GO:0016021 GO:0016020 GO:0005739 GO:0005886 GO:0045211 GO:0016206 GO:0000287 GO:0008171 GO:0016036 GO:0032502 GO:0042420 GO:0008210 GO:0007565 GO:0007612 GO:0032259 GO:0048609 GO:0045963 GO:0035814 GO:0048662 GO:0042136 GO:0042135 GO:0050668 GO:0051930 GO:0042493 GO:0032496 GO:0014070 GO:0048265 GO:0007614 GO:0044281 GO:0007268 GO:0006805
Gene3D	3.40.50.150
InterPro	IPR017128 IPR002935 IPR029063
PANTHER	PTHR10509
Pfam	PF01596
PIRSF	PIRSF037177
SUPFAM	SSF53335
PROSITE	PS51682

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0070062	extracellular exosome	PMID:23533145^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0042424	catecholamine catabolic process	PMID:21846718^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016206	catechol O-methyltransferase activity	PMID:21846718^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042424	catecholamine catabolic process	PMID:15645182^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016206	catechol O-methyltransferase activity	PMID:15645182^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042424	catecholamine catabolic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3769724 PANTHER:PTN000053580 UniProtKB:P21964	P		Seeded From UniProt	complete
involved_in	GO:0042417	dopamine metabolic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88470 PANTHER:PTN000053580	P		Seeded From UniProt	complete
involved_in	GO:0032502	developmental process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000053580 RGD:2379	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000053602 RGD:2379	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000053602 RGD:2379	C		Seeded From UniProt	complete
enables	GO:0016206	catechol O-methyltransferase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3769724 MGI:MGI:88470 PANTHER:PTN000053580 RGD:2379 UniProtKB:P21964	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000053602 RGD:2379	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042420	dopamine catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88587 ensembl:ENSMUSP00000130077	P		Seeded From UniProt	complete
involved_in	GO:0042417	dopamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88587 ensembl:ENSMUSP00000130077	P		Seeded From UniProt	complete
enables	GO:0016206	catechol O-methyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88587 ensembl:ENSMUSP00000130077	F		Seeded From UniProt	complete
involved_in	GO:0016036	cellular response to phosphate starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88587 ensembl:ENSMUSP00000130077	P		Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
involved_in	GO:0050668	positive regulation of homocysteine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
involved_in	GO:0048609	multicellular organismal reproductive process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
involved_in	GO:0048265	response to pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
involved_in	GO:0045963	negative regulation of dopamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	C		Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	C		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
involved_in	GO:0035814	negative regulation of renal sodium excretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
involved_in	GO:0032502	developmental process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	C		Seeded From UniProt	complete
enables	GO:0016206	catechol O-methyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	C		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
involved_in	GO:0008210	estrogen metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
involved_in	GO:0007614	short-term memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22734 ensembl:ENSRNOP00000043148	C		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017128	F		Seeded From UniProt	complete
involved_in	GO:0006584	catecholamine metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017128	P		Seeded From UniProt	complete
enables	GO:0008171	O-methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002935	F		Seeded From UniProt	complete
enables	GO:0016206	catechol O-methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017128	F		Seeded From UniProt	complete
involved_in	GO:0042135	neurotransmitter catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017128	P		Seeded From UniProt	complete
enables	GO:0016206	catechol O-methyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.6	F		Seeded From UniProt	complete
enables	GO:0102938	orcinol O-methyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.6	F		Seeded From UniProt	complete
enables	GO:0102084	L-dopa O-methyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.6	F		Seeded From UniProt	complete
enables	GO:0008171	O-methyltransferase activity	PMID:1707278^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032259	methylation	Reactome:R-HSA-156581	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016206	catechol O-methyltransferase activity	Reactome:R-HSA-175983	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	Reactome:R-HSA-379464 Reactome:R-HSA-379387	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-379464 Reactome:R-HSA-379387	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-175983	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F		Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006584	catecholamine metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0128	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0042135	neurotransmitter catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0531	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^4.0 ^4.1 Chen, J et al. (2011) Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development. J. Biol. Chem. 286 34752-60 PubMed GONUTS page
↑ ^5.0 ^5.1 Lee, SG et al. (2005) Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans. Hum. Genet. 116 319-28 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Lundström, K et al. (1991) Cloning and characterization of human placental catechol-O-methyltransferase cDNA. DNA Cell Biol. 10 181-9 PubMed GONUTS page

[PMID:23533145-1] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19946888-2] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19056867-3] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:21846718-4] 4.0 ^4.1 Chen, J et al. (2011) Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development. J. Biol. Chem. 286 34752-60 PubMed GONUTS page

[PMID:15645182-5] 5.0 ^5.1 Lee, SG et al. (2005) Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans. Hum. Genet. 116 319-28 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1707278-7] Lundström, K et al. (1991) Cloning and characterization of human placental catechol-O-methyltransferase cDNA. DNA Cell Biol. 10 181-9 PubMed GONUTS page

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HUMAN:COMT

Contents

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