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HUMAN:COM1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RBBP8 (synonyms: CTIP)
Protein Name(s) DNA endonuclease RBBP8

CtBP-interacting protein CtIP Retinoblastoma-binding protein 8 RBBP-8 Retinoblastoma-interacting protein and myosin-like RIM Sporulation in the absence of SPO11 protein 2 homolog SAE2

External Links
UniProt Q99708
EMBL AF043431
U72066
AK292481
BX648221
AC091147
AC106033
CH471088
BC030590
CCDS CCDS11874.1
CCDS11875.1
RefSeq NP_002885.1
NP_976036.1
NP_976037.1
XP_006722582.1
XP_006722583.1
XP_006722584.1
XP_006722585.1
UniGene Hs.546282
PDB 2L4Z
PDBsum 2L4Z
ProteinModelPortal Q99708
SMR Q99708
BioGrid 111867
DIP DIP-24244N
IntAct Q99708
MINT MINT-102295
STRING 9606.ENSP00000323050
PhosphoSite Q99708
DMDM 116242745
MaxQB Q99708
PaxDb Q99708
PRIDE Q99708
DNASU 5932
Ensembl ENST00000327155
ENST00000399722
ENST00000399725
GeneID 5932
KEGG hsa:5932
UCSC uc002ktw.3
uc002ktz.3
CTD 5932
GeneCards GC18P020378
GeneReviews RBBP8
HGNC HGNC:9891
HPA HPA039890
HPA052946
MIM 251255
604124
606744
neXtProt NX_Q99708
Orphanet 313795
808
PharmGKB PA34255
eggNOG NOG145529
GeneTree ENSGT00530000063835
HOGENOM HOG000293331
HOVERGEN HBG057046
InParanoid Q99708
OrthoDB EOG771274
PhylomeDB Q99708
TreeFam TF106469
Reactome REACT_27271
ChiTaRS RBBP8
EvolutionaryTrace Q99708
GeneWiki RBBP8
GenomeRNAi 5932
NextBio 23118
PRO PR:Q99708
Proteomes UP000005640
Bgee Q99708
CleanEx HS_RBBP8
ExpressionAtlas Q99708
Genevestigator Q99708
GO GO:0005730
GO:0005634
GO:0017053
GO:0003684
GO:0001103
GO:0001106
GO:0000014
GO:0001835
GO:0000075
GO:0000737
GO:0010792
GO:0006281
GO:0000724
GO:0000082
GO:0031572
GO:0051321
GO:0007067
GO:0000122
GO:0006357
InterPro IPR019518
IPR013882
Pfam PF10482
PF08573

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006289

nucleotide-excision repair

PMID:23144634[1]

ECO:0000315

P

Figure 1. CtIP depletion sensitizes cells to ICL inducing agents.

complete
CACAO 5872

involved_in

GO:0006289

nucleotide-excision repair

PMID:23144634[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0017053

transcriptional repressor complex

PMID:16287852[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

PMID:16287852[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001103

RNA polymerase II repressing transcription factor binding

PMID:16287852[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q96T58

F

Seeded From UniProt

complete

involved_in

GO:0010792

DNA double-strand break processing involved in repair via single-strand annealing

PMID:18716619[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010792

DNA double-strand break processing involved in repair via single-strand annealing

PMID:19202191[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003684

damaged DNA binding

PMID:18716619[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000724

double-strand break repair via homologous recombination

PMID:20829486[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000014

single-stranded DNA endodeoxyribonuclease activity

PMID:18716619[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000014

single-stranded DNA endodeoxyribonuclease activity

PMID:19202191[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070336

flap-structured DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000387514
PomBase:SPCC338.08

F

Seeded From UniProt

complete

part_of

GO:0035861

site of double-strand break

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000387514
PomBase:SPCC338.08

C

Seeded From UniProt

complete

involved_in

GO:0010792

DNA double-strand break processing involved in repair via single-strand annealing

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000387514
UniProtKB:Q99708

P

Seeded From UniProt

complete

involved_in

GO:0006289

nucleotide-excision repair

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000387514
UniProtKB:Q99708

P

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000387514
PomBase:SPCC338.08

F

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000387514
PomBase:SPCC338.08

F

Seeded From UniProt

complete

enables

GO:0003684

damaged DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000387514
UniProtKB:Q99708

F

Seeded From UniProt

complete

involved_in

GO:0000724

double-strand break repair via homologous recombination

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000387514
PomBase:SPCC338.08
UniProtKB:Q99708

P

Seeded From UniProt

complete

enables

GO:0000406

double-strand/single-strand DNA junction binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000387514
PomBase:SPCC338.08

F

Seeded From UniProt

complete

enables

GO:0000403

Y-form DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000387514
PomBase:SPCC338.08

F

Seeded From UniProt

complete

enables

GO:0000014

single-stranded DNA endodeoxyribonuclease activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000387514
UniProtKB:Q99708

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25558984[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99708

F

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004519

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004519

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004518

P

Seeded From UniProt

complete

involved_in

GO:1903507

negative regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003714

P

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B1WC58
ensembl:ENSRNOP00000017291

P

Seeded From UniProt

complete

involved_in

GO:0001835

blastocyst hatching

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80YR6
ensembl:ENSMUSP00000111527

P

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80YR6
ensembl:ENSMUSP00000111527

P

Seeded From UniProt

complete

involved_in

GO:0000724

double-strand break repair via homologous recombination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033594

P

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013882
InterPro:IPR033594

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033594

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013882

P

Seeded From UniProt

complete

involved_in

GO:0010792

DNA double-strand break processing involved in repair via single-strand annealing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033594

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:10764811[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:10764811[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10764811[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-5684887
Reactome:R-HSA-5684882
Reactome:R-HSA-5684875
Reactome:R-HSA-5684140
Reactome:R-HSA-5684108
Reactome:R-HSA-5684096
Reactome:R-HSA-5684081
Reactome:R-HSA-9007625
Reactome:R-HSA-6799332
Reactome:R-HSA-5693620
Reactome:R-HSA-5693608
Reactome:R-HSA-5693593
Reactome:R-HSA-5693589
Reactome:R-HSA-5693584
Reactome:R-HSA-5693580
Reactome:R-HSA-5693564
Reactome:R-HSA-5693561
Reactome:R-HSA-5693542
Reactome:R-HSA-5693539
Reactome:R-HSA-5687675
Reactome:R-HSA-5687673
Reactome:R-HSA-5687664
Reactome:R-HSA-5687653
Reactome:R-HSA-5687640
Reactome:R-HSA-5687484
Reactome:R-HSA-5687465
Reactome:R-HSA-5687464
Reactome:R-HSA-5686657
Reactome:R-HSA-5686642
Reactome:R-HSA-5686483
Reactome:R-HSA-5686469
Reactome:R-HSA-5686440
Reactome:R-HSA-5686410
Reactome:R-HSA-5685994
Reactome:R-HSA-5685985
Reactome:R-HSA-5685953
Reactome:R-HSA-5685838
Reactome:R-HSA-5685341
Reactome:R-HSA-5685156
Reactome:R-HSA-5685011

ECO:0000304

author statement supported by traceable reference used in manual assertion








































C

Seeded From UniProt

complete

involved_in

GO:0000729

DNA double-strand break processing

Reactome:R-HSA-5693608

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000724

double-strand break repair via homologous recombination

Reactome:R-HSA-5693538

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070317

negative regulation of G0 to G1 transition

Reactome:R-HSA-8953750

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

Reactome:R-HSA-5684887
Reactome:R-HSA-5684875

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0051321

meiotic cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0469

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158
UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0255

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Duquette, ML et al. (2012) CtIP is required to initiate replication-dependent interstrand crosslink repair. PLoS Genet. 8 e1003050 PubMed GONUTS page
  2. 2.0 2.1 2.2 Oswald, F et al. (2005) RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol. Cell. Biol. 25 10379-90 PubMed GONUTS page
  3. 3.0 3.1 3.2 Huertas, P et al. (2008) CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455 689-92 PubMed GONUTS page
  4. 4.0 4.1 Huertas, P & Jackson, SP (2009) Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J. Biol. Chem. 284 9558-65 PubMed GONUTS page
  5. Kaidi, A et al. (2010) Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329 1348-53 PubMed GONUTS page
  6. 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. Davies, OR et al. (2015) CtIP tetramer assembly is required for DNA-end resection and repair. Nat. Struct. Mol. Biol. 22 150-157 PubMed GONUTS page
  8. 8.0 8.1 8.2 Yu, X & Baer, R (2000) Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. J. Biol. Chem. 275 18541-9 PubMed GONUTS page