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HUMAN:COM1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | RBBP8 (synonyms: CTIP) | |
Protein Name(s) | DNA endonuclease RBBP8
CtBP-interacting protein CtIP Retinoblastoma-binding protein 8 RBBP-8 Retinoblastoma-interacting protein and myosin-like RIM Sporulation in the absence of SPO11 protein 2 homolog SAE2 | |
External Links | ||
UniProt | Q99708 | |
EMBL | AF043431 U72066 AK292481 BX648221 AC091147 AC106033 CH471088 BC030590 | |
CCDS | CCDS11874.1 CCDS11875.1 | |
RefSeq | NP_002885.1 NP_976036.1 NP_976037.1 XP_006722582.1 XP_006722583.1 XP_006722584.1 XP_006722585.1 | |
UniGene | Hs.546282 | |
PDB | 2L4Z | |
PDBsum | 2L4Z | |
ProteinModelPortal | Q99708 | |
SMR | Q99708 | |
BioGrid | 111867 | |
DIP | DIP-24244N | |
IntAct | Q99708 | |
MINT | MINT-102295 | |
STRING | 9606.ENSP00000323050 | |
PhosphoSite | Q99708 | |
DMDM | 116242745 | |
MaxQB | Q99708 | |
PaxDb | Q99708 | |
PRIDE | Q99708 | |
DNASU | 5932 | |
Ensembl | ENST00000327155 ENST00000399722 ENST00000399725 | |
GeneID | 5932 | |
KEGG | hsa:5932 | |
UCSC | uc002ktw.3 uc002ktz.3 | |
CTD | 5932 | |
GeneCards | GC18P020378 | |
GeneReviews | RBBP8 | |
HGNC | HGNC:9891 | |
HPA | HPA039890 HPA052946 | |
MIM | 251255 604124 606744 | |
neXtProt | NX_Q99708 | |
Orphanet | 313795 808 | |
PharmGKB | PA34255 | |
eggNOG | NOG145529 | |
GeneTree | ENSGT00530000063835 | |
HOGENOM | HOG000293331 | |
HOVERGEN | HBG057046 | |
InParanoid | Q99708 | |
OrthoDB | EOG771274 | |
PhylomeDB | Q99708 | |
TreeFam | TF106469 | |
Reactome | REACT_27271 | |
ChiTaRS | RBBP8 | |
EvolutionaryTrace | Q99708 | |
GeneWiki | RBBP8 | |
GenomeRNAi | 5932 | |
NextBio | 23118 | |
PRO | PR:Q99708 | |
Proteomes | UP000005640 | |
Bgee | Q99708 | |
CleanEx | HS_RBBP8 | |
ExpressionAtlas | Q99708 | |
Genevestigator | Q99708 | |
GO | GO:0005730 GO:0005634 GO:0017053 GO:0003684 GO:0001103 GO:0001106 GO:0000014 GO:0001835 GO:0000075 GO:0000737 GO:0010792 GO:0006281 GO:0000724 GO:0000082 GO:0031572 GO:0051321 GO:0007067 GO:0000122 GO:0006357 | |
InterPro | IPR019518 IPR013882 | |
Pfam | PF10482 PF08573 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0006289 |
nucleotide-excision repair |
ECO:0000315 |
P |
Figure 1. CtIP depletion sensitizes cells to ICL inducing agents. |
complete | |||||
involved_in |
GO:0006289 |
nucleotide-excision repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0017053 |
transcriptional repressor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003714 |
transcription corepressor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0001103 |
RNA polymerase II repressing transcription factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010792 |
DNA double-strand break processing involved in repair via single-strand annealing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010792 |
DNA double-strand break processing involved in repair via single-strand annealing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003684 |
damaged DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000724 |
double-strand break repair via homologous recombination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000014 |
single-stranded DNA endodeoxyribonuclease activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000014 |
single-stranded DNA endodeoxyribonuclease activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0070336 |
flap-structured DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387514 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0035861 |
site of double-strand break |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387514 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010792 |
DNA double-strand break processing involved in repair via single-strand annealing |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387514 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006289 |
nucleotide-excision repair |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387514 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003697 |
single-stranded DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387514 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003690 |
double-stranded DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387514 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003684 |
damaged DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387514 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000724 |
double-strand break repair via homologous recombination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387514 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0000406 |
double-strand/single-strand DNA junction binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387514 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000403 |
Y-form DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387514 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000014 |
single-stranded DNA endodeoxyribonuclease activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387514 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004519 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004519 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004518 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903507 |
negative regulation of nucleic acid-templated transcription |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0003714 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032355 |
response to estradiol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1WC58 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001835 |
blastocyst hatching |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q80YR6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000082 |
G1/S transition of mitotic cell cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q80YR6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000724 |
double-strand break repair via homologous recombination |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004519 |
endonuclease activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010792 |
DNA double-strand break processing involved in repair via single-strand annealing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-5684887 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0000729 |
DNA double-strand break processing |
Reactome:R-HSA-5693608 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000724 |
double-strand break repair via homologous recombination |
Reactome:R-HSA-5693538 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1901796 |
regulation of signal transduction by p53 class mediator |
Reactome:R-HSA-5633007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070317 |
negative regulation of G0 to G1 transition |
Reactome:R-HSA-8953750 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006260 |
DNA replication |
Reactome:R-HSA-5684887 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
enables |
GO:0004518 |
nuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051321 |
meiotic cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051301 |
cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004519 |
endonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Duquette, ML et al. (2012) CtIP is required to initiate replication-dependent interstrand crosslink repair. PLoS Genet. 8 e1003050 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Oswald, F et al. (2005) RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol. Cell. Biol. 25 10379-90 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Huertas, P et al. (2008) CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455 689-92 PubMed GONUTS page
- ↑ 4.0 4.1 Huertas, P & Jackson, SP (2009) Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J. Biol. Chem. 284 9558-65 PubMed GONUTS page
- ↑ Kaidi, A et al. (2010) Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329 1348-53 PubMed GONUTS page
- ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Davies, OR et al. (2015) CtIP tetramer assembly is required for DNA-end resection and repair. Nat. Struct. Mol. Biol. 22 150-157 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Yu, X & Baer, R (2000) Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. J. Biol. Chem. 275 18541-9 PubMed GONUTS page
c
d
- GO:0003684 ! damaged DNA binding
- GO:0003677 ! DNA binding
- GO:0006974 ! DNA damage response
- GO:0010792 ! DNA double-strand break processing involved in repair via single-strand annealing
- GO:0000729 ! DNA double-strand break processing
- GO:0006281 ! DNA repair
- GO:0006260 ! DNA replication
- GO:0000724 ! double-strand break repair via homologous recombination
- GO:0003690 ! double-stranded DNA binding
- GO:0000406 ! double-strand/single-strand DNA junction binding
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