HUMAN:CO6A1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	COL6A1
Protein Name(s)	Collagen alpha-1(VI) chain
External Links
UniProt	P12109
EMBL	X15879 X15880 BC005159 BC052575 X99109 X99135 X99136 M20776 S75420 S75385 S75388 S75390 S75392 S75394 S75396 S75398 S75400 S75402 S75404 S75406 S75408 S75410 S75412 S75414 S75416 S75418 X06194 M27447
CCDS	CCDS13727.1
PIR	S05377
RefSeq	NP_001839.2
UniGene	Hs.474053
ProteinModelPortal	P12109
SMR	P12109
BioGrid	107688
IntAct	P12109
STRING	9606.ENSP00000355180
ChEMBL	CHEMBL2364188
PhosphoSite	P12109
DMDM	125987811
REPRODUCTION-2DPAGE	IPI00291136 P12109
MaxQB	P12109
PaxDb	P12109
PeptideAtlas	P12109
PRIDE	P12109
Ensembl	ENST00000361866
GeneID	1291
KEGG	hsa:1291
UCSC	uc002zhu.1
CTD	1291
GeneCards	GC21P047401
GeneReviews	COL6A1
HGNC	HGNC:2211
HPA	HPA019142 HPA029401
MIM	120220 158810 254090
neXtProt	NX_P12109
Orphanet	610 75840
PharmGKB	PA26727
eggNOG	NOG256042
GeneTree	ENSGT00760000119051
HOVERGEN	HBG095954
InParanoid	P12109
KO	K06238
OMA	VKENYAE
OrthoDB	EOG71K628
PhylomeDB	P12109
TreeFam	TF331207
Reactome	REACT_121139 REACT_13552 REACT_150180 REACT_150401 REACT_163906 REACT_16888 REACT_18312
ChiTaRS	COL6A1
GeneWiki	Collagen,_type_VI,_alpha_1
GenomeRNAi	1291
NextBio	5227
PMAP-CutDB	P12109
PRO	PR:P12109
Proteomes	UP000005640
Bgee	P12109
CleanEx	HS_COL6A1
ExpressionAtlas	P12109
Genevestigator	P12109
GO	GO:0005589 GO:0005788 GO:0031012 GO:0005576 GO:0070062 GO:0005765 GO:0016020 GO:0043234 GO:0005578 GO:0042383 GO:0048407 GO:0007411 GO:0007155 GO:0071230 GO:0030574 GO:0035987 GO:0022617 GO:0030198 GO:0001649 GO:0070208
Gene3D	3.40.50.410
InterPro	IPR008160 IPR002035
Pfam	PF01391 PF00092
SMART	SM00327
SUPFAM	SSF53300
PROSITE	PS50234

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:28327460^[1]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(CL:0002540)\|occurs_in:(CL:0002570)\|occurs_in:(CL:0002551)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28327460^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002540)\|part_of:(CL:0002570)\|part_of:(CL:0002551)	Seeded From UniProt	complete
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q1T7A8	F	occurs_in:(UBERON:0002084)	Seeded From UniProt	complete
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:20551380^[2]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0001496)	Seeded From UniProt	complete
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:27559042^[3]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0006618) occurs_in:(UBERON:0002302)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28675934^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0003688)\|part_of:(UBERON:0001911)	Seeded From UniProt	complete
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:28675934^[4]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0003688)\|occurs_in:(UBERON:0001911)	Seeded From UniProt	complete
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:25037231^[5]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:25037231^[5]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0001155)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001155)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:27559042^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0006618) part_of:(UBERON:0002302)	Seeded From UniProt	complete
involved_in	GO:0035987	endodermal cell differentiation	PMID:23154389^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:23658023^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:16210410^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000134)\|part_of:(CL:0000062)	Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	PMID:16210410^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P	results_in_determination_of:(CL:0000134)	Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:20551380^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001496)	Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:22261194^[13]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q1T7A8	C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:17897319^[14]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005589	collagen type VI trimer	PMID:2551668^[15]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109613 MGI:MGI:1341272 MGI:MGI:1921449 MGI:MGI:2179729 MGI:MGI:2684334 MGI:MGI:88462 PANTHER:PTN001523162 UniProtKB:O43405 ZFIN:ZDB-GENE-030131-9889	C		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106591 MGI:MGI:109613 MGI:MGI:1278313 MGI:MGI:1328350 MGI:MGI:1921449 MGI:MGI:2179729 MGI:MGI:88459 MGI:MGI:88460 MGI:MGI:88461 PANTHER:PTN001523162 UniProtKB:P12111	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2684334 MGI:MGI:88461 MGI:MGI:96924 PANTHER:PTN001523162 RGD:3055 RGD:67380 UniProtKB:P11226 UniProtKB:Q5GFL6	C		Seeded From UniProt	complete
involved_in	GO:0003429	growth plate cartilage chondrocyte morphogenesis	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106591 PANTHER:PTN001523162	P		Seeded From UniProt	complete
involved_in	GO:0070208	protein heterotrimerization	PMID:18400749^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12110	P		Seeded From UniProt	complete
enables	GO:0048407	platelet-derived growth factor binding	PMID:8900172^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:18400749^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12110	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:18400749^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04857 ensembl:ENSMUSP00000001147	P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04857 ensembl:ENSMUSP00000001147	C		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04857 ensembl:ENSMUSP00000001147	C		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	Reactome:R-HSA-1474244	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8944247 Reactome:R-HSA-2089971 Reactome:R-HSA-2022073 Reactome:R-HSA-1614461 Reactome:R-HSA-1614460	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-4084903 Reactome:R-HSA-382054 Reactome:R-HSA-375151 Reactome:R-HSA-2466106 Reactome:R-HSA-2327909 Reactome:R-HSA-2327695 Reactome:R-HSA-2213207 Reactome:R-HSA-2089971 Reactome:R-HSA-1564112	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005581	collagen trimer	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0176	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
↑ ^2.0 ^2.1 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
↑ ^4.0 ^4.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ Brafman, DA et al. (2013) Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 20 369-81 PubMed GONUTS page
↑ Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^12.0 ^12.1 Foster, LJ et al. (2005) Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Stem Cells 23 1367-77 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page
↑ Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page
↑ Chu, ML et al. (1989) Sequence analysis of alpha 1(VI) and alpha 2(VI) chains of human type VI collagen reveals internal triplication of globular domains similar to the A domains of von Willebrand factor and two alpha 2(VI) chain variants that differ in the carboxy terminus. EMBO J. 8 1939-46 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Fitzgerald, J et al. (2008) Three novel collagen VI chains, alpha4(VI), alpha5(VI), and alpha6(VI). J. Biol. Chem. 283 20170-80 PubMed GONUTS page
↑ Somasundaram, R & Schuppan, D (1996) Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB). J. Biol. Chem. 271 26884-91 PubMed GONUTS page

[PMID:28327460-1] 1.0 ^1.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page

[PMID:20551380-2] 2.0 ^2.1 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page

[PMID:27559042-3] 3.0 ^3.1 Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page

[PMID:28675934-4] 4.0 ^4.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page

[PMID:25037231-5] 5.0 ^5.1 ^5.2 ^5.3 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page

[PMID:27068509-6] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:23154389-7] Brafman, DA et al. (2013) Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 20 369-81 PubMed GONUTS page

[PMID:23658023-8] Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page

[PMID:23533145-9] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19199708-10] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:19056867-11] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:16210410-12] 12.0 ^12.1 Foster, LJ et al. (2005) Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Stem Cells 23 1367-77 PubMed GONUTS page

[PMID:22261194-13] Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page

[PMID:17897319-14] Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page

[PMID:2551668-15] Chu, ML et al. (1989) Sequence analysis of alpha 1(VI) and alpha 2(VI) chains of human type VI collagen reveals internal triplication of globular domains similar to the A domains of von Willebrand factor and two alpha 2(VI) chain variants that differ in the carboxy terminus. EMBO J. 8 1939-46 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18400749-17] 17.0 ^17.1 ^17.2 Fitzgerald, J et al. (2008) Three novel collagen VI chains, alpha4(VI), alpha5(VI), and alpha6(VI). J. Biol. Chem. 283 20170-80 PubMed GONUTS page

[PMID:8900172-18] Somasundaram, R & Schuppan, D (1996) Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB). J. Biol. Chem. 271 26884-91 PubMed GONUTS page

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HUMAN:CO6A1

Contents

Annotations

Notes

References

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