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HUMAN:CNTRB

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CNTROB (synonyms: LIP8)
Protein Name(s) Centrobin

Centrosomal BRCA2-interacting protein LYST-interacting protein 8

External Links
UniProt Q8N137
EMBL AY160226
AY160227
AF331638
AL137669
AL833907
AC104581
BC014055
BC021134
AK074847
AF141344
CCDS CCDS11126.1
CCDS32557.1
RefSeq NP_001032221.1
NP_444279.2
XP_005256494.1
UniGene Hs.348012
ProteinModelPortal Q8N137
BioGrid 125533
IntAct Q8N137
MINT MINT-2878302
STRING 9606.ENSP00000369614
PhosphoSite Q8N137
DMDM 74728485
MaxQB Q8N137
PaxDb Q8N137
PRIDE Q8N137
DNASU 116840
Ensembl ENST00000380262
ENST00000563694
ENST00000565740
GeneID 116840
KEGG hsa:116840
UCSC uc002gjp.3
uc002gjq.3
uc002gjr.3
CTD 116840
GeneCards GC17P007835
HGNC HGNC:29616
HPA HPA023319
HPA023320
HPA023321
HPA023325
MIM 611425
neXtProt NX_Q8N137
PharmGKB PA143485436
eggNOG NOG128239
GeneTree ENSGT00610000086191
HOVERGEN HBG081290
InParanoid Q8N137
KO K16468
OMA AMLQAHW
OrthoDB EOG7KH9J6
PhylomeDB Q8N137
TreeFam TF337444
ChiTaRS CNTROB
GeneWiki CNTROB
GenomeRNAi 116840
NextBio 80002
PRO PR:Q8N137
Proteomes UP000005640
Bgee Q8N137
CleanEx HS_CNTROB
ExpressionAtlas Q8N137
Genevestigator Q8N137
GO GO:0005814
GO:0005813
GO:0005737
GO:0019904
GO:0007099
GO:0051299
GO:1902410

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007099

positive regulation of centriole replication

PMID:21576394[1]

ECO:0000315

P

Figure 3

complete
CACAO 6966

GO:0005813

protein localization to centrosome

PMID:21576394[1]

ECO:0000315

P

Figure 5

complete
CACAO 6969

part_of

GO:0005814

centriole

PMID:27185865[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21576394[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007099

centriole replication

PMID:21576394[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051299

centrosome separation

PMID:16275750[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007099

centriole replication

PMID:16275750[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:16275750[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1902410

mitotic cytokinetic process

PMID:16275750[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

PMID:11984006[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99698

F

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21399614[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1902410

mitotic cytokinetic process

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002438084
UniProtKB:Q8N137

P

Seeded From UniProt

complete

involved_in

GO:0051299

centrosome separation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002438084
UniProtKB:Q8N137

P

Seeded From UniProt

complete

involved_in

GO:0007099

centriole replication

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002438084
UniProtKB:Q8N137

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035295
PANTHER:PTN002438084
UniProtKB:Q8N137

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002438084
UniProtKB:Q8N137

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007099

centriole replication

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038923

P

Seeded From UniProt

complete

involved_in

GO:1902017

regulation of cilium assembly

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038923

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0046

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Gudi, R et al. (2011) Centrobin-tubulin interaction is required for centriole elongation and stability. J. Cell Biol. 193 711-25 PubMed GONUTS page
  2. Chang, CW et al. (2016) CEP295 interacts with microtubules and is required for centriole elongation. J. Cell. Sci. 129 2501-13 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Zou, C et al. (2005) Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication. J. Cell Biol. 171 437-45 PubMed GONUTS page
  4. Tchernev, VT et al. (2002) The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. Mol. Med. 8 56-64 PubMed GONUTS page
  5. Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page